Antibody diversity: Somatic hypermutation of rearranged VH genes

Cell

Volumn 27, Issue 3 PART 2, 1981, Pages 573-581

  Kim, Stuart ^a   Davis, Mark ^a   Sinn, Eric ^a   Patten, Phil ^a   Hood, Leroy ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; PHOSPHORYLCHOLINE;

ANTIBODY PRODUCTION; B LYMPHOCYTE; GENE EXPRESSION; GENE STRUCTURE; HEREDITY; IN VITRO STUDY; LYMPHATIC SYSTEM; MOUSE; MUTATION;

ANIMALS; ANTIBODY DIVERSITY; BASE SEQUENCE; DNA; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MUTATION;

EID: 0019847882     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(81)90399-8     Document Type: Article

References (43)

1. The three dimensional structure of a combining-site ligand complex of immunoglobulin NEW at 3.5 Å resolution
2. Somatic mutation gains its place among the generators of diversity
3. Screening λgt recombinant clones by hybridization to single plaques in situ
4. Sequences of mouse immunoglobulin light chain genes before and after somatic changes
5. Charon phages: super derivatives of bacteriophage lambda for DNA cloning
6. A general method for isolation of high molecular weight DNA from eukaryotes
7. b family of antibodies: somatic mutation evident in a γ2a variable region
8. A complete immunoglobulin gene is created by somatic recombination
9. Origin of antibody variation
10. HIII subgroup: definitive identification of four heavy chain hypervariable regions
11. Studies of generation of B-cell diversity in mouse, man, and chicken
12. H gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody
13. An immunoglobulin heavy-chain gene is formed by at least two recombinational events
14. DNA sequences mediating class switching in alpha immunoglobulin genes
15. A membrane-filter technique for the detection of complementary DNA
16. Mouse immunoglobulin genes
17. H
18. IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts
19. Sequences at the joining region genes for immunoglobulin heavy chains and their role in generation of antibody diversity
20. Packaging recombinant DNA molecules into bacteriophage particles in vitro
21. The structure and genetics of mouse immunoglobulins an analysis of NZB myeloma proteins and sets of BALB/c myeloma proteins binding particular haptens
22. Two types of rearrangements in immunoglobulin genes
23. Rearrangement of immunoglobulin γ1-chain gene and a mechanism for heavy chain class switch
24. Identification of D segments of immunoglobulin heavy chain genes and their rearrangements in T lymphocytes
25. Immunoglobulin diversity. Regulation of expression of immunoglobulin genes during primary development of B cells
26. Exon shuffling generates an immunoglobulin heavy chain gene
27. The isolation of structural genes from libraries of eucaryotic DNA
28. Sequence of five potential recombination sites encoded close to an immunoglobulin κ constant region gene
29. Sequencing end-labeled DNA with base-specific chemical cleavages
30. Differences between germline and rearranged immunoglobulin sequences suggest a localized mutational mechanism
31. Development and modulation of B lymphocytes: studies on newly formed B cells and their putative precursors in the hemopoietic tissues of mice
32. Sequences at the somatic recombination sites of immunoglobulin lightchain genes
33. Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes
34. A κ immunoglobulin gene is formed by site-specific recombination without further somatic mutation
35. Nucleotide sequence of the E. coli gene coding for dihydrofolate reductase
36. Detection of specific sequences among DNA fragments separated by gel electrophoresis
37. In vitro packaging of a λ Dam-vector containing Eco RI fragments of E. coli and phage P1
38. Multiplicity of germline genes specifying a group of related mouse κ chains with implications for the generation of immunoglobulin diversity
39. Genetic control of antibody variable regions
40. Variability in the lambda light chain sequences of mouse antibody
41. Rearrangement of genetic information may produce immunoglobulin diversity
42. The joining of V and J gene segments creates antibody diversity
43. An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chain and their implications for antibody complementarity