Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genes

Cell

Volumn 27, Issue 3 PART 2, 1981, Pages 583-591

  Ravetch, Jeffrey V ^a   Siebenlist, Ulrich ^a   Korsmeyer, Stanley ^b   Waldmann, Thomas ^c   Leder, Philip ^a,b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN M;

BLOOD AND HEMOPOIETIC SYSTEM; EMBRYO; GENE STRUCTURE; HUMAN CELL; IMMUNOGLOBULIN GENE; NORMAL HUMAN;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; DNA; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN MU-CHAINS; MICE; MOLECULAR SEQUENCE DATA; PSEUDOGENES;

EID: 0019846077     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(81)90400-1     Document Type: Article

References (37)

1. Screening λgt recombinant clones by hybridization to single plaques in situ
2. An immunoglobulin heavy chain gene is formed by at least two recombinational events
3. H
4. Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways
5. In vitro packaging of lambda Dam vectors and their use in cloning DNA fragments
6. Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments
7. Human immunoglobulin kappa light chain genes are deleted or rearranged in lambda producing B cells
8. Sequences of immunoglobulin chains
9. Multiple immunoglobulin switch region homologies exist outside the heavy chain constant region locus
10. Computer analysis of nucleic acids and proteins
11. A hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B cells
12. The organization of immunoglobulin genes and the origin of their diversity
13. Mapping of heavy chain genes for mouse immunoglobulins M and D
14. Enhanced graphic matrix analysis of nucleic acid and protein sequences
15. The isolation of structural genes from libraries of eucaryotic DNA
16. Sequence of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene
17. Variation in the crossover point of kappa immunoglobulin gene V-J recombination: evidence from a cryptic gene
18. Sequencing of end-labeled DNA with base-specific chemical cleavages
19. J genes for heavy chain immunoglobulins of mouse
20. μ gene is composed of simple tandem repetitive sequences
21. 2-microglobulin cDNA clones: a screening procedure for cDNA clones corresponding to rare mRNAs
22. Evolutionary approach to the question of immunoglobulin heavy chain switching: evidence from cloned human and mouse genes
23. Sequences at the somatic recombination sites of immunoglobulin light chain genes
24. Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy chain genes
25. Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy chain genes
26. DNA sequencing with chain terminating inhibitors
27. Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing
28. The arrangement and rearrangement of antibody genes
29. The molecular basis of antibody diversity: a mechanism derived from the structure of cloned antibody genes
30. A kappa immunoglobulin gene is formed by site-specific recombination without further somatic mutation
31. BKV splice sequences based on analysis of preferred donor and acceptor sites
32. Human immunoglobulin D segments encoded in tandem multigenic families
33. A comparison of two cloned mouse β-globin genes and their surrounding and intervening sequences
34. Multiplicity of germline genes specifying a group of related mouse kappa chains with implications for the generation of immunoglobulin diversity
35. A bacterial clone synthesizing proinsulin
36. The joining of V and J gene segments creates antibody diversity