Measurement of the renal clearance of drugs.

British Journal of Clinical Pharmacology

Volumn 12, Issue 6, 1981, Pages 761-770

  Tucker, GT ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALLOPURINOL; AMINO ACID; AMMONIUM CHLORIDE; BICARBONATE; NICOTINE; OXIPURINOL; PENICILLIN G; PHENOBARBITAL; PROBENECID; SALICYLIC ACID DERIVATIVE; SUCROSE; VITAMIN;

CLEARANCE; DRUG CLEARANCE; DRUG URINE LEVEL; KIDNEY; MATHEMATICAL MODEL; METHODOLOGY; NONBIOLOGICAL MODEL; PHARMACOKINETICS;

ABSORPTION; AGING; CHEMISTRY, PHYSICAL; GLOMERULAR FILTRATION RATE; HUMAN; HYDROGEN-ION CONCENTRATION; KIDNEY; KIDNEY DISEASES; KINETICS; PHARMACEUTICAL PREPARATIONS; RENAL CIRCULATION;

EID: 0019819005     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.1981.tb01304.x     Document Type: Article

References (56)

1. Urinary excretion kinetics of amphetamine in man
2. Use of the analogue computer to examine the quantitative relation between urinary pH and kidney reabsorption of drugs partially ionized at physiological pH
3. Use of the analogue computer to predict the distribution and excretion of drugs under conditions of fluctuating urinary pH
4. Metabolism of salicylic acid in the isolated perfused rat kidney. Interconversion of salicyluric and salicylic acids
5. the function of the urinary tract as ‘dead space’ in clearance experiments
6. Drug movement from the isolated urinary bladder of the rabbit
7. 35S furosemide and its depression by albumin binding
8. The significance of the difference in systemic arterial venous blood concentrations in renal clearance methods
9. Examinations in of the delay‐time of the kidney
10. Critical evaluation of the potential error in pharmacokinetic studies using the linear trapezoidal rule method for the calculation of the area under the plasma level‐time curve
11. Time‐dependent change in renal clearance of bethanidine in humans
12. Absorption of saccharin from rat urinary bladder
13. Inconstancy of renal clearance values with changing plasma concentrations
14. Pharmacokinetics in the elderly
15. Interrelationship between renal haemodynamics, drug kinetics and drug action
16. Renal failure, drug pharmacokinetics and drug action
17. Pharmacokinetics and clearances related to renal processes
18. Studies on the absorption, distribution and elimination of alcohol. VIII. The diuresis from alcohol and its influence on the elimination of alcohol in the urine
19. Comparative serum concentration and excretion experiments with benzyl penicillin (G) and phenoxymethyl penicillin (V) on a single subject
20. Guanethidine: Pharmacokinetics during acute and chronic treatment and influence upon the peripheral sympathetic nervous system
21. Pharmacokinetics of beta‐methyldigoxin in healthy humans. I: Intravenous studies
22. Urinary excretion and metabolism of pethidine and norpethidine in the newborn
23. Renal contribution to drug biotransformation
24. Intravenous thiobarbiturate anaesthesia for Caesarian section
25. Novel method for bioavailability assessment
26. Absolute drug bioavailability: Approximation without comparison to parenteral dose for compounds exhibiting perturbable renal clearance
27. Effect of plasma protein binding on renal clearance of drugs
28. Methods of forced diuresis and its appliction in barbiturate poisoning
29. Drug urinary excretion data—some aspects concerning the interpretation
30. Effect of exercise on renal clearance of atenolol
31. Effect of pH and urine flow on urinary nicotine excretion after smoking cigarettes
32. Non‐ionic diffusion and the excretion of weak acids and bases
33. Clinical pharmacokinetics in neonates
34. Clinical pharmacokinetics in newborns and infants: Age‐related differences and therapeutic implications
35. Renal excretion by non‐ionic diffusion. The nature of the disequilibrium
36. Absolute availability of lithium
37. Clinical pharmacokinetics in infants and children
38. The binding of drugs to plasma proteins from patients with poor renal function
39. Effect of experimental azotemia on renal clearance of furosemide in the dog
40. Depression of renal clearance of furosemide in man by azotemia
41. Pharmacokinetics of bethanidine in hypertensive patients
42. The disposition of debrisoquine in hypertensive patients
43. Renal tubular secretion of digoxin
44. The renal excretion of drugs
45. Negligible excretion of unchanged ketoprofen, naproxen and probenecid in urine
46. Renal contribution to overall metabolism of drugs. IV: Biotransformation of salicylic acid to salicyluric acid in man
47. Renal contribution to overall metabolism of drugs. I: Conversion of benzoic acid to hippuric acid
48. Renal contribution to overall metabolism of drugs. II: Biotransformation of salicylic acid to salicyluric acid
49. Renal contribution to overall metabolism of drugs. Ill: Metabolism of p ‐aminobenzoic acid
50. Excretion of drugs by the kidney
51. Bidirectional transport: Urate and other organic anions
52. Renal tubular mechanisms for excretion of organic acids and bases
53. Effects of tubular secretion and reabsorption on titration curves of tubular transport
54. Effect of serum protein binding on sulfisoxazole distribution, metabolism and excretion in rats