Elevated Maternal Hemoglobin A1C in Early Pregnancy and Major Congenital Anomalies in Infants of Diabetic Mothers

New England Journal of Medicine

Volumn 304, Issue 22, 1981, Pages 1331-1334

  Miller, Edith ^a   Hare, John W ^a   Cloherty, John P ^a   Dunn, Peter J ^a   Gleason, Ray E ^a   Soeldner, J Stuart ^a   Kitzmiller, John L ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN A1C;

BLOOD AND HEMOPOIETIC SYSTEM; CONGENITAL DISORDER; CONGENITAL MALFORMATION; DIABETES MELLITUS; ENDOCRINE SYSTEM; GENETIC COUNSELING; MATERNAL DISEASE; NEWBORN; NORMAL HUMAN; NORMAL VALUE; PREGNANCY; TERATOGENESIS;

EID: 0019798973     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198105283042204     Document Type: Article

References (21)

1. Kitzmiller J.L., Cloherty J.P., Younger M.D., et al. Diabetic pregnancy and perinatal morbidity. Am J Obstet Gynecol. 1978; 131:560-580.
2. Gabbe S.G., Mestman J.H., Freeman R.K., et al. Management and outcome of pregnancy in diabetes mellitus, classes B to R. Am J Obstet Gynecol. 1977; 129:723-732.
3. Pedersen J. The pregnant diabetic and her newborn: problems and management. 2nd ed. Baltimore: Williams & Wilkins, 1977: 123-97.
4. Holmes L.B. Congenital malformations. In: Cloherty JP, Stark AR, eds. Manual of neonatal care. Boston: Little, Brown, 1980: 91-6.
5. Mills J.L., Baker L., Goldman A.S. Malformations in infants of diabetic mothers occur before the seventh gestational week: implications for treatment. Diabetes. 1979; 28:292-293.
6. Bunn H.F., Haney D.N., Kamin S., Gabbay K.H., Gallop P.M. The biosynthesis of human hemoglobin A1c: slow glycosylation of hemoglobin in vivo. J Clin Invest. 1976; 57:1652-1659.
7. Dunn P.J., Cole R.A., Soeldner J.S., et al. Temporal relationship of glycosylated haemoglobin concentrations to glucose control in diabetics. Diabetologia. 1979; 17:213-220.
8. White P. Diabetes mellitus in pregnancy. Clin Perinatol. 1974; 1:331-347.
9. Cole R.A., Soeldner J.S., Dunn P.J., Bunn H.F. A rapid method for the determination of glycosylated hemoglobins using high pressure liquid chromatography. Metabolism. 1978; 27:289-301.
10. Gabbe S.C. Congenital malformations in infants of diabetic mothers. Obstet Gynecol Surv. 1977; 32:125-132.
11. Kalter H., Warkany J. Experimental production of congenital malformations in mammals by metabolic procedure. Physiol Rev. 1959; 39:69-115.
12. Sadler T.W. Effects of maternal diabetes on early embryogenesis. II. Hyperglycemia-induced exencephaly. Teratology. 1980; 21:349-356.
13. Kucera J. Rate and type of congenital anomalies among offspring of diabetic women. J Reprod Med. 1971; 7:61-70.
14. Karlsson K., Kjellmer I. The outcome of diabetic pregnancies in relation to the mothers#x0027; blood sugar level. Am J Obstet Gynecol. 1972; 112:213-220.
15. Leslie R.D.G., Pyke D.A., John P.N., White J.M. Haemoglobin A1 in diabetic pregnancy. Lancet. 1978; 2:958-959.
16. Vlachokosta F., Koenig R., Cahill G.F. Jr., Soeldner J.S. Evidence of reversibility of hemoglobin (Hb) Alc. Diabetes. 1980; 29:22A. abstract.
17. Goldstein D.E., Peth S.B., England J.D., Hess R.L., Da Costa J. Effects of acute changes in blood glucose on HbA1c. Diabetes. 1980; 29:623-628.
18. Widness J.A., Rogler-Brown T.L., McCormick K.L., et al. Rapid fluetuations in glycohemoglobin (hemoglobin A1c) related to acute changes in glucose. J Lab Clin Med. 1980; 95:386-394.
19. Mølsted-Pedersen L., Tygstrup I., Pedersen J. Congenital malformations in newborn infants of diabetic women: correlation with maternal diabetic vascular complications. Lancet. 1964; 1:1124-1126.
20. Koller O. Diabetes and pregnancy. Acta Obstet Gynecol Scand. 1953; 32:80-103.
21. Driscoll S.G. The pathology of pregnancy complicated by diabetes mellitus. Med Clin North Am. 1965; 49:1053-1067.