Antihypertensive Pyrrolo[l,2-c]quinazolines and Pyrrolo[1,2-c]quinazolinones

Journal of Medicinal Chemistry

Volumn 24, Issue 12, 1981, Pages 1455-1460

  Bandurco, Victor T ^a   Wong, Elizabeth Malloy ^a   Levine, Seymour D ^a   Hajos, Zoltán G ^a  

^a Ortho McNeil Pharmaceutical Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT;

ANIMAL EXPERIMENT; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; DRUG SYNTHESIS; HYPERTENSION; IN VITRO STUDY; METHODOLOGY; ORAL DRUG ADMINISTRATION; PYRROLO[1,2 C]QUINAZOLINE DERIVATIVE; PYRROLO[1,2 C]QUINAZOLINONE DERIVATIVE; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; STRUCTURE ACTIVITY RELATION;

ANIMAL; ANTIHYPERTENSIVE AGENTS; MALE; QUINAZOLINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0019770896     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00144a017     Document Type: Article

References (29)

1. For a recent review, see, W. L. F. Armarego, Adv. Heterocycl. Chem., 1, 253 (1963).
2. F. Ablondi, S. Gordon, J. Morton II, and J. H. Williams, J. Org. Chem., 17, 14 (1952).
3. A. H. Amin and D. R. Mehta, Nature (London), 184, 1317 (1959);
4. A. Jansen and D. A. Jarman, Nature (London)., 196, 1217 (1962).
5. E. Cohen, B. Klarberg, and J. R. Vaughan, Jr., J. Am. Chem. Soc., 82, 2731 (1960);
6. G. deStevens, “Diuretics”, Academic Press, New York, 1963, p 112.
7. E. Wulfert, P. Bolla, and J. Mathieu, Chim. Ther., 257 (1969);
8. T. Komatsu, H. Awata, Y. Sakai, T. Inukai, M. Yamamoto, S. Inaba, and H. Yamamoto, Arzneim.-Forsch., 22, 1958 (1972);
9. H. Yamamoto, C. Saito, S. Inaba, M. Awata, M. Yamamoto, Y. Sakai, and T. Komatsu, Arzneim.-Forsch., 23, 1266 (1973);
10. R. V. Coombs, R. P. Dana, M. Denzer, G. E. Hardtmann, B. Huegi, G. Koletar, H. Ott, E. Jukneiwicz, J. W. Perrine, E. I. Takesue, and J. H. Trapold, J. Med. Chem., 16, 1237 (1973);
11. M. Yamamoto, S. Katayama, and K. Masao (Sumitomo Chemical Co., Ltd.), Ger. Off en., 2702 530 (1977).
12. G. Deysson, and R. Truhaut, Ann. Pharm. Fr., 23, 229 (1965).
13. G. Muacevič, H. Stötzer, and H. Wick, Arzneim.-Forsch., 15, 613 (1965).
14. H. J. Hess, T. H. Cronin, and A. Scriabine, J. Med. Chem., 11, 130 (1967);
15. S. Hayao, H. J. Havera, W. G. Strycker, T. J. Leipzig, R. A. Kulp, and H. E. Hartzler, J. Med. Chem., 8, 807 (1965);
16. S. M. Deshpande and K. R. Reddy, Indian J. Chem., 15B, 198 (1977);
17. T. Takahashi, H. Sugimoto, Jpn. Kokai, 76, 82285 (1976);
18. R. N. Brogden, R. C. Hell, T. M. Speight, and G. S. Avery, Drugs, 14, 163 (1977);
19. Z. Buděšinsky and P. Lederer, Collect. Czech. Chem. Commun., 37, 2779 (1972).
20. J. W. Lown and K. Matsumoto, Can. J. Chem., 49, 1165 (1971);
21. S. Beveridge and J. L. Huppatz, Aust. J. Chem., 23, 781 (1970);
22. E. Ajello, Chem. Abstr., 77, 152110 p (1970).
23. W. L. F. Armarego and J. I. C. Smith, J. Chem. Soc., 234 (1966);
24. A. Albert and A. Hampton, J. Chem. Soc., 506 (1954);
25. M. Yamamoto, K. Masao, and I. Shigeho (Sumitomo Chemical Co., Ltd.) U. S. Patent 4096 144 (1977).
26. C. R. Ellefson, L. Swenton, R. H. Bible, Jr., and P. M. Green, Tetrahedron, 32, 1081 (1975);
27. Robert E. Lyle and George A. Heavner, J. Org. Chem., 40, 50 (1975).
28. P. Klinke and H. Gibian, Chem. Ber., 94, 26 (1961);
29. A. R. Osborn and K. Shofield, J. Chem. Soc., 2100 (1955).