2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation

Neuroscience Letters

Volumn 21, Issue 1, 1981, Pages 77-81

  Davies, J ^a   Francis, A A ^b   Jones, A W ^b   Watkins, J C ^b  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b Dept Anat Sch Med Sci U   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; ACETYLCHOLINE; AMINO ACID; AMINO ACID RECEPTOR; ASPARTIC ACID; GLUTAMIC ACID; HOMOCYSTEIC ACID; KAINIC ACID; QUISQUALIC ACID;

ANIMAL EXPERIMENT; CAT; CENTRAL NERVOUS SYSTEM; DOSE RESPONSE; DRUG ANTAGONISM; DRUG COMPARISON; DRUG RESPONSE; DRUG SPECIFICITY; DRUG SYNTHESIS; FROG; IN VITRO STUDY; NERVOUS SYSTEM; RENSHAW CELL; SHORT SURVEY; SYNAPTIC STIMULATION; SYNAPTIC TRANSMISSION;

2-AMINO-5-PHOSPHONOVALERATE; AMINO ACIDS; ANIMAL; ANURA; ASPARTIC ACID; CATS; EVOKED POTENTIALS; N-METHYLASPARTATE; RECEPTORS, CELL SURFACE; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, NEUROTRANSMITTER; SPINAL CORD; SUPPORT, NON-U.S. GOV'T; SYNAPSES;

EID: 0019723082     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(81)90061-6     Document Type: Article

References (16)

1. Depression of synaptic excitation and of amino acid induced excitatory responses of spinal neurones by d-α-aminoadipate, α,ϵ-diaminopimelic acid and HA-966
2. d-α-Aminoadipate, α,ϵ-diaminopimelic acid, and HA-966 as antagonists of amino acid-induced and synaptic excitation of mammalian spinal neurones in vivo
3. d-α-Aminoadipate as a selective antagonist of amino acid-induced and synaptic excitation of mammalian spinal neurones
4. A new synthesis of aminophosphonic acids
5. The synaptic excitation of Renshaw cells
6. Excitatory amino acid receptors and synaptic excitation in the mammalian central nervous system
7. Selective antagonism of amino acid-induced and synaptic excitation in the cat spinal cord
8. Antagonism of excitatory amino acid-induced responses and of synaptic excitation in the isolated spinal cord of the frog
9. 2+-like selective antagonism of excitatory amino acid-induced responses by α,ϵ-diaminopimelic acid, d-α-aminoadipate and HA-966 in isolated spinal cord of frog and immature rat
10. In vivo inactivation of quisqualate; studies in the cat spinal cord
11. Selective antagonism by d-α-aminoadipate of amino acid and synaptic excitation of cat spinal neurones
12. The antagonism of amino acid-induced excitation of spinal neurones in the cat
13. Excitatory amino acids
14. Glutamate as a transmitter of hippocampal perforant path