The agonistic-antagonistic properties of clomiphene: A review

Pharmacology and Therapeutics

Volumn 15, Issue 3, 1981, Pages 467-519

  Clark, James H ^a   Markaverich, Barry M ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOMIFENE; ENCLOMIFENE; ESTRADIOL; HORMONE RECEPTOR; NAFOXIDINE; RADIOISOTOPE; ZUCLOMIFENE CITRATE;

ANIMAL EXPERIMENT; CLOMIFENE DERIVATIVE; DRUG TOXICITY; ENDOCRINE SYSTEM; ESTRADIOL BENZOATE H 3; FEMALE GENITAL SYSTEM; INTOXICATION; OVARY; OVARY FOLLICLE; OVULATION; OVULATION INDUCTION; REVIEW; UTERUS;

ABNORMALITIES, DRUG-INDUCED; ANIMAL; BEHAVIOR, ANIMAL; CHEMISTRY; CLOMIPHENE; ESTROGEN ANTAGONISTS; ESTROGENS, SYNTHETIC; FEMALE; HUMAN; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LETHAL DOSE 50; MALE; MICE; OVULATION; PREGNANCY; RATS; SUPPORT, U.S. GOV'T, P.H.S.; UTERUS;

EID: 0019722049     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/0163-7258(81)90055-3     Document Type: Article

References (346)

1. Treatment of refractory anovulation with increased dosage and prolonged duration of cyclic clomiphene citrate
2. Alterations induced by clomiphene in the concentrations of oesterogen receptors in the uterus, pituitary gland and hypothalamus of female rats
3. Effects of administration of clomiphene on reproduction in female cockroaches
4. Outcome of pregnancy after clomiphene therapy
5. Clomiphene citrate therapy for male infertility
6. The action of clomiphene on hormonal secretions
7. Gynaecomastia and impotence associated with abnormal testosterone binding
8. The relationship between nuclear receptor estrogen binding and uterotrophic responses
9. Estrogen-induced uterine responses and growth: relationship to receptor estrogen binding by uterine nuclei
10. The in vitro effects of clomiphene citrate on 6-day rabbit blastocyts and their subsequent in vivo development
11. Effect of anti-estrogen on steroid induced sexual receptivity in ovariectomized rats
12. Update on the safety and efficacy of clomiphene citrate as a therapeutic agent
13. Effects of clomiphene citrate on the plasma steroid levels of rat in the first half of pregnancy
14. Studies of cholesterol biosynthesis. I. The identification of desmosterol in serum and tissues of animals and man treated with MER-29
15. Effect of clomiphene upon plasma FSH-activity and hypothalamic FSH-RF content in ovariectomized estrogen-progesterone blocked rats
16. The effect of clomiphene on the restoration of ovulation in androgen sterile rats
17. Anti-estrogens and plasma proteins. I. Clomiphene and isomers, ethamoxytriphetol, U-11, 100A and U-11, 555A
18. Studies of the pituitary-leydig cell axis in young men with hypogonadotropic hypogonadism and hyposmia: comparison with normal men, prepuberal boys, and hypopituitary patients
19. Abstr. of Preliminary Report
20. Effects of ethamoxytriphetol, MRL-37, and clomiphene on reproduction in rats
21. Anencephaly, ovulation stimulation, subfertility and illegitimacy
22. Cycle regulation with clomiphene citrate: A double-blind study
23. Antifertility effect of three new clomiphene analogues on animals
24. Cytoplasmic oestrogen receptor replenishment: oestrogens versus antioestrogens
25. Congenital abnormalities associated with maternal clomiphene ingestion
26. Effect of some antiestrogens and aromatase inhibitors on androgen induced sexual behavior in castrated male rats
27. Gonadotropin release after implantation of anti-estrogens in the pituitary and hypothalamus of goldfish
28. Uterine bioassay of tamoxifen, trioxifene and a new estrogen antagonist (LY117018) in rats and mice
29. Effects of clomiphene cis and trans isomers on sterol metabolism in the rat
30. Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues
31. Increased frequency of chromosomal anomalies in abortions after induced ovulation
32. Retrospective and prospective epidemiological studies of 1500 karyotyped spontaneous human abortions
33. Effects of clomiphene citrate on pituitary FSH, FSH-RF, and release of LH in immature and mature rats
34. In vivo effects of antiestrogens on the localization and replenishment of estrogen recpetor
35. The effect of clomiphene on the plasma androgens of prepubertal and pubertal boys
36. Effects of certain antifertility agents on the development of rabbit ova
37. The endometrial karyotypic profiles of women after clomiphene citrate therapy
38. Possible mode of action of clomiphene. I. Reversal of clomiphene-induced interruption of decidual growth and gestation by prolactin or progesterone in rats
39. The possible mode of action of prostaglandins: XI. Clomiphene citrate and the reversal of luteolytic or abortifacient efficacy of prostaglandin F2alpha in rats
40. Estrogen receptor-antiestrogen complex: Atypical binding by uterine nuclei and effects on uterine growth
41. Oestrogen receptors and antagonism of steroid hormone action
42. Nuclear retention of receptor-oestrogen complex and nuclear acceptor sites
43. Clomid or nafoxidine administered to neonatal rats causes reproductive tract anbormalities
44. Nuclear binding and retention of the receptor estrogen complex: Relation to the agonistic and antagonistic properties of estriol
45. Role of estrogen receptor binding and transcriptional activity in the stimulation of hyperestrogenization and nuclear bodies
46. Nuclear binding of the estrogen receptor: Heterogeneity of sites and uterotrophic response
47. Effect of clomiphene and other triphenylethylene derivatives on the reproductive tract in the rat and baboon
48. The agonistic and antagonistic effects of clomiphene citrate and its isomers
49. Effects of clomiphene on the mouse uterus
50. Induction of ovulation with cislomiphene and a placebo
51. Influence of two nonsteroidal antiestrogens on vaginal opening and PMS-induced ovulation in rats
52. Reversal of the effects of anti-oestrogens and norethynodrel on gonadotropin-induced ovulation in rats
53. The efficacy of two non-steroidal antifertility agents after topical administration in rats
54. Teratology in the macaca mulatta
55. Physiology of lactation
56. Studies on the anti-oestrogenic and oestrogen-like action of clomiphene citrate in women
57. Studies of the fine structure of ovarian interstitial tissue. 6. Effects of clomiphene on the thecal gland of the domestic fowl
58. Anti-estrogenic compounds increase prolactin and growth hormone synthesis in clonal strains of rat pituitary cells
59. Effects of clomiphene at different stages of pregnancy in the rat, implications regarding possible action mechanisms
60. Effects of cis-clomiphene on serum LH and prolactin levels and on the response to LH-RH in the ewe
61. Effects of certain basic phenolic ethers on the rat fetus
62. Effect of cis and trans isomers of clomiphene citrate on uterine hexokinase activity
63. Ovulation-inducing action of clomiphene citrate in the rat
64. Studies on the anti-ovulatory action of clomiphene citrate in the rat
65. Oestrogenic activity of some hydrocarbon derivatives of ethylene
66. The action of clomiphene in the ferret
67. Effects of oestradiol 17β, oestradiol benzoate and the synthetic oestrogen R.U. 2858 on sexual differentiation in the neonatal female rat
68. Continued clinical experience with an increasing dosage regimen of clomiphene citrate administration
69. Antifertility activities of two diphenyl-dihydronapthalene derivatives (28070)
70. Anencephaly and ovulation stimulation
71. Clomiphene citrate in the treatment of luteal phase defects
72. Evidence for estradiol binding sites in the hypothalamus: Effect of drugs
73. Estrogen receptor in the mammalian liver
74. Oestrogenic, anti-oestrogenic and anti-fertility activity
75. Hydramnios and congenital cataracts induced in rats by clomiphene
76. An effect in vitro of clomiphene on the rate of conversion of androstenedione-C14 to estrone-C14 and estradiol-C14 by the canine ovary
77. Heterogeneity of estrogen receptors in the cytosol and nuclear fractions of the rat uterus
78. Stereochemistry of geometric isomers of clomiphene: A correction of the literature and a reexamination of structure-activity relationships
79. The induction of ovulation
80. Suppression of lordosis in guinea pigs by ethamoxy-triphentol (MER-25) given at long intervals (34–46 hr) after estradiol treatment
81. Keimdrusenfunktion der ratte nach post-order pranataler injektion von clomiphen. (Germ gland function of the rat after post-natal or pre-natal injection of clomiphene)
82. Die keimdrusenfunktion der ratte nach prae- oder postnataler injektion verschiedener hormone. (Gonadal function in rats followffing pre- or postnatal injection of various hormones)
83. Ovulation stimulation and defects of neural-tube closure
84. Alterations in the male reproductive tract of rats treated with clomiphene
85. Investigation of the biogenetic reaction of cholesterol in rat tissue through inhibition with AY-9944
86. The effect of hypocholesteremic agents on myelinogeneis
87. Selective blockade of estrogen induced uterine responses by the anti-estrogen
88. The use of clomiphene citrate
89. The effect of estrogen on the incidence of mammary and pituitary tumors in mice
90. Effects of oestradiol-17β on uterine ribosomes: altered sedimentation profile and enhanced protein-synthesizing activity
91. 24-unsaturated sterols of rat skin
92. Persistent estrus and altered estrogen sensitivity in rats treated neonatally with clomiphene citrate
93. The specificity of oestrogen receptor in brain, pituitary and uterus
94. Induction of ovulation
95. Agents affecting lipid metabolism. XV. Biochemical studies with the cholesterol biosynthesis inhibitor AY-9944 in young and mature rat
96. Teratology for the obstetrician: Current status
97. Critical review of 160 clomiphene-related pregnancies
98. Morphological findings in granular reticulum of arcuate nucleus neurons after clomiphene citrate administration
99. Ovulation and pregnancy rates with clomiphene citrate
100. Effects of low dosages of androgen on the differentiation of hypothalamic regulatory control of ovulation in the rat
101. Current models of steroid hormone action: a critique
102. Induction of ovulation with MRL/41. Preliminary Report
103. Induction of ovulation
104. Estrogen induced hypospadias in the female rat
105. Induction of ovulation by clomiphene citrate
106. Failure of clomiphene to interpret gestation in rats treated with reserpine
107. Mechanism of the stimulatory effect of clomid on aromatization of steroids by human placenta in vitro
108. Functional and morphological alterations of the reproductive system of the female rat following prepuberal treatment with estrogen
109. Suppression of ovarian steroidogenesis in vitro by clomiphene and its bearing on the mode of action of clomiphene in vivo
110. Effect of clomiphene citrate on corticosteroid-binding globulin and serum progesterone levels during ovulation induction
111. Estrogen receptor binding by uterine nuclei relationship to endogenous nuclear RNA polymerase activity
112. The effect of clomiphene on endocrine function in normal men
113. Inhibition of the ovarian augmentation reaction by a chemical antiestrogen
114. Effect of high and low doses of clomid on the ovary, diencephalic ependyma and thyroid in the pigeon
115. Effect of clomiphene citrate on basal and LRH-induced gonadotropin secretion in postmenopausal women
116. Clomiphene citrate: A correlation of its effect on sperm concentration and morphology, total gonadotropins, ICSH, estrogen and testosterone excretion and testicular cytology in normal men
117. The estrogen-cancer hypothesis
118. Effect of clomiphene on testicular protein synthesis in vitro
119. Study on the inhibitory effect of clomiphene on testicular protein synthesis
120. Effect of in vivo and in vitro administration of clomiphene on RNA synthesis in rat testis
121. Gonadotrophin inhibiting and antifecundity effect of chloramiphene
122. Sterols of skin in the normal and triparanol treated rat
123. Veränderungen des Hypophysenorderlappens und des Ovariums nach Behandlung mit grossen Dosen von Follikelhormon
124. Nuclear estrogen receptors: effects of inhibitors on processing and steady state levels
125. Sensitisation of pituitary cells to luteinising hormone releasing hormone by clomiphene citrate in vitro
126. Some hypocholesteremic 2,3-Diphenylacrylonitriles
127. Mode and site of action of clomiphene
128. Plasma luteinizing hormone during clomiphene-induced ovulatory cycles
129. Basic guides to the mechanism of estrogen action
130. Mechanism of action of the female sex hormones
131. The efficacy of clomiphene citrate for induction of ovulation: A controlled study
132. Induction of ovulation with human gonadotropins and with clomiphene
133. Dose-related effects of anti-oestrogens and oestrogens on the measurement of cytoplasmic oestrogen receptors in the rat and mouse uterus
134. Inhibition of cell division and stimulation of progesterone receptor synthesis in rat oestrogen target tissues by non-steroidal anti-oestrogens
135. Estradiol “receptors” in hypothalamus and anterior pituitary gland: inhibition of estradiol binding by SH-group blocking agents and clomiphene citrate
136. Clomiphene citrate in suppression of puerperal lactation
137. Effect of clomiphene on fertility in male rats
138. Effect of FSH and testosterone propionate on spermatogeneis in immature rats treated with clomiphene
139. Effect of clomiphene on fertility in female rats
140. Modulation of uterine morphology and growth by estradiol-17β and estrogen antagonist
141. Studies on physiology and biochemistry of female genital tract: response of uterus, cervix and vagina of albino rats to cis- and trans-clomiphene in the presence or absence of estrogen
142. Anovulation
143. Effect of clomiphene on the uptake of estradiol by the anterior hypothalamus and hypophysis
144. Anti-estrogen action in the uterus: Biological ineffectiveness of nuclear bound estradiol after antiestrogen
145. Anti-estrogen interaction with uterine estrogen receptors
146. Effects of clomiphene (MRL-41) on the reproductive organs of the indian desert gerbil
147. Studies on the mechanism of puberty in man
148. Effects of clomiphene citrate and progesterone on resting and proliferative cell-populations in mouse uterine epithelium
149. Inhibition of sexual development in male and female rats treated with various steroids at the age of five days
150. Observations on the use of non-steroidal estrogen antagonist: MER-25. II. Effects in endometrial hyperplasia and Stein-Leventhal Syndrome
151. Effects of clomiphene citrate on endometrial hyperplasia in the premenopausal female
152. Effects of high doses of estrogen on prolactin binding activity and growth of carcinogen-induced mammary cancers in rats
153. The neuroendocrine control of the menstrual cycle
154. The effect of promethazine and clomiphene on gonadotrophin secretion in the rat
155. Effects of 17 beta-oestradiol and clomiphene isomers on uterine ribosomes
156. Clomiphene and tamoxifen action in the rat uterus
157. Differential depletion of cytoplasmic high affinity oestrogen receptors after the in vivo administration of the antioestrogens clomiphene, MER-25 and Tamoxifen
158. The role of oestrogens in spontaneous ovulation: evidence for positive oestrogen feedback in the 4-day oestrous cycle
159. Mechanism of action of hypothalamic hormones in the anterior pituitary gland and specific modulation of their activity by sex steroids and thyroid hormones
160. Endocrine control of clutch size in reptiles. VIII. Anti-estrogenic effects of clomiphene citrate in the lizard
161. Cataracts in patients treated with triparanol
162. The influence of oestradiol and anti-oestrogens on hepatic microsomal 3 beta-hydroxy-steroid dehydrogenase activity in rats
163. Persistent anovulatory estrus (PAE) caused by clomiphene or coumestrol
164. Regulation of progesterone receptor formation by estrogen action
165. Hormone antagonists: inhibitors of specific activities of estrogen and androgen
166. A non-steroidal estrogen antagonist 1-(p-2-diethylaminoethoxyphenyl)-1-phenyl-2-p-methoxyphenyl ethanol
167. Correlation of anti-inflammatory activity with inhibition of prostaglandin synthesis activity of nonsteroidal anti-estrogen and estrogens
168. The action of clomiphene in the ewe
169. Androgenization: alterations in uterine growth and morphology
170. Studies of clomiphene effects on rabbit embryo development and biosynthetic activity
171. Concentrations of prostaglandins F2 alpha and E2 in the endometrium throughout the human menstrual cycle after the administration of clomiphene or an oestrogen-progestogen pill and in early pregnancy
172. RNA transcription and uterine growth: Differential effects of estradiol, estriol and nafoxidine on chromatin RNA initiation sites
173. Two binding sites for estradiol in rat uterine nuclei: Relationship to uterotrophic response
174. Two binding sites for estradiol in rat uterine nuclei: Relationship to stimulation and antagonism of uterine growth
175. Differential stimulation of uterine cells by nafoxidine and clomiphene: relationship between nuclear estrogen receptors and type II estrogen binding sites and cellular growth
176. Biologic effects of clomiphene citrate in the castrate rhesus monkey
177. Effects du clomiphene sur l'accouchement de la ratte (Effects of clomiphene on delivery in the rat)
178. Action anti-oestrogene du clomiphene sur la nidation (the anti-estrogenic effect of clomiphene on nidation)
179. Clomifene, nidation et survie des foetus (Clomiphene, nidation, and survival of the fetus)
180. Induction of ovulation
181. Estrogens, anti-estrogens and the regulation of cell proliferation in the female reproductive tract in vivo
182. Poliquistosis experimental de la rata hembra por administracion de citrato de clomifeno en el animal recien nacido (Experimental polycystic ovarian disease in the rat induced by the administration of clomiphene citrate to the newborn animal)
183. 3H-estradiol binding by “receptors” in rats: differential effects of clomiphene and androgen sterilization
184. Experimental investigation of the effect of clomiphene on the gonadotrophin secretion of the rat pituitary
185. Clomid administration to pregnant rats causes abnormalities of the reproductive tract in offspring and mothers
186. Differential responses of individual uterine cell types from immature rats treated with estradiol
187. Inhibition of androgen-sterilization in the female rat by administration of an anti-estrogen
188. The effect of clomiphene citrate in chickens. I. Androgenic and estrogenic activity
189. Effect of clomiphene citrate, hysterectomy, and human chorionic gonadotropin on the estrous cycle and ovaries of guinea pigs
190. Further studies on the action of steroids and triphenylethylene derivatives on the neonatal rat
191. Effect of an oestrogen antagonist ethamoxytriphetol (MER-25) on oestrus behaviour in rats
192. Effect of MRL-41 on postpartum breast manifestations
193. Inhibition of estrogen induced glycogen synthesis in the rat by clomiphene
194. Effects of the anti-estrogens MER-25 and CI-628 on rat and hamster lordosis
195. Anovulation and oviductal hyperplasia in rats treated with clomiphene citrate 5 days after birth
196. Compounds interfering with ovum implantation and development. II. Synthetic estrogens and anti-estrogens
197. Postcoital antifertility agents and their teratogenic effect
198. Oestrogen-induced synthesis of thiamin-binding protein in immature chicks. Kinetics of induction, hormonal specificity and modulation
199. Estrogen stimulation of chicken liver ornithine decarboxylase: relationship between the levels of enzyme and poly A-enriched RNA
200. Estrogen-induced synthesis of riboflavin-binding protein in immature chicks. Kinetics and hormonal specificity
201. Contrasting actions of cis- and trans-clomiphene on the release of FSH and FSH-RF in the female rat
202. Effect of clomiphene on testes and pituitaries of male rats
203. Clomiphene and neural tube defects
204. Toxicologic studies on clomiphene
205. Effect of synthetic oestrogenic substances on the body-growth and endocrine organs in the rat
206. Increased prevalence of Down's syndrome (mongolism) among the offspring of women treated with ovulation-inducing agents
207. Effect of clomiphene citrate on corpora lutea of pregnant rats: an ultrastructural study
208. Female steroid hormones and target cell nuclei
209. Substituted aminoalkoxytriarylhaloethylenes
210. Induction of ovulation in goldfish by clomiphene citrate
211. Mode of action of clomiphene citrate in inducing ovulation of goldfish
212. Antiestrogenic action of clomiphene citrate in goldfish
213. Clomiphene citrate in the management of male hypofertility: predictors for treatment selection
214. Estrophilic binding sites of the uterus: relation to uptake and retention of estradiol in vitro
215. Reduction of growth hormone secretion following clomiphene administration
216. Side effects of triparanol therapy
217. Regulation of human gonadotropins. III. Luteinizing hormone and follicle stimulation hormone in sera from adult males
218. Induction of ovulation with clomiphene (1965)
219. The oestrogenic and anti-oestrogenic activity of some synthetic steroids and non-steroids
220. Histochemical study of estrogenuc and anti-estrogenic effects of clomiphene citrate on glycogen synthesis by myometrium and luminal epithelium of rat uterus
221. The interaction of clomiphene, estradiol and progesterone in the control of rat uterine glycogen metabolism
222. Effect of clomiphene on blastocysts during delayed implantation in the rat
223. Effect of hypocholesterolemic agents on central nervous system cholesterol biosynthesis—I. Zuclomiphene
224. Effect of hypocholesterolemic agents on central nervous system cholesterol biosynthesis—II. AY-9944 and AY-9944 plus zuclomiphene
225. Effects of zuclomiphene in combination with triparanol and AY-9944 on developing rat CNS morphology and biochemistry
226. Effect of zuclomiphene on cholesterol formation in the developing central nervous system of the rat
227. Effect of extended hypocholesterolemic drug treatment on peripheral and central nervous system sterol content of the rat
228. Effect of hypocholesterolemic agents on central nervous system cholesterol biosynthesis. III. Zuclomiphene in combination with AY-9944 and triparanol
229. Alteration of developing and adult rat muscle membranes by zuclomiphene and other hypocholesterolemic agents
230. Gonadotrophin release in ovariectomized patients. I. Suppression by clomiphene or low doses of ethinyl oestradiol
231. Effect of AY-9944, a cholesterol biosynthesis inhibitor, on peripheral nerve myelination
232. Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome
233. Effect of cis- and trans-clomiphene on mammary gland development in the rat
234. Protein hormone action: a key to understanding ovarian follicular and luteal cell development
235. Effects of clomiphene citrate on anovulatory ovarian function
236. Anti-oestrogen: uterine nuclear retention of CI-628 anti-oestrogen receptor complex in vitro
237. Use of clomiphene citrate to induce estrus in anestrous mares
238. Oestrus reactions, including mating, produced by triphenylethylene
239. Formation of estrogen nuclear receptor in uterus: effect of androgens, estrone and Nafoxidine
240. Gonadotropins and preantral follicular maturation in women
241. Pituitary and gonadal hormones in women during spontaneous and induced ovulatory cycles
242. Effect of clomiphene citrate and its isomers on sexual behavior in ovariectomized rats
243. Effects of cis- and trans-clomiphene in the induction of sexual behavior
244. Clomiphene citrate: further observations on its use in induction of ovulation in the human and on its mode of action
245. CLOMIPHENE CITRATE
246. Effects of clomiphene on the physiology of reproduction in the rat. I. Changes in the hypophyseal-gonadal axis
247. Effects of clomiphene on the physiology of reproduction in the rat. II. Its oestrogenic and anti-oestrogenic actions
248. Effects of clomiphene on the physiology of reproduction in the rat. III. Inhibition of uptake of radioactive oestradiol by the uterus and the pituitary gland of immature rat
249. Different nuclear binding sites for anti-estrogen and estrogen receptor complexes
250. The effect of anti-estrogens on the nuclear binding of the estrogen receptor
251. An individualized graduated therapeutic regimen for clomiphene citrate
252. Anencephaly and ovulation stimulation
253. Prolonged anti-oestrogen action of clomiphene in rat during delayed implantation
254. Long-term stimulation with clomiphene citrate in hypogonadal males
255. Short- and long-term effects of clomiphene citrate on the pituitary-testicular asis
256. Inhibition by triparanol of cholesterol formation in the brain of the newborn mouse
257. Alteration of LH and FSH release in rats treated with clomiphene on its isomers
258. Recent progress in pharmacological therapy of male subfertility—a review
259. Effect of anti-estrogens on estrogen-induced ova implantation in the ovariectomized rat
260. Suppression of the decidual response with estrogen antagonists
261. The investigation and treatment of patients with ovulation failure: with special reference to the problems arising with the use of clomiphene
262. Studies with 14C labeled clomiphene citrate
263. Wirkung des antioestrogens clomiphen auf die reaktion deradenohypophyse auf oestradiol (effect of the anti-estrogen clomiphene on the raction of the adenohypophyse to estradiol)
264. Die intrazellulare verteilung von (14C) clomid (MRL-41) in verschiedenen organen des infantilen weiblichen neerschweinchens (The intracellular distribution of (14C) clomid (MRL-41) in various organs of the immature female guinea pig)
265. Female endocrine control mechanisms during the neonatal period. III. The effect of clomiphene citrate
266. Studies on the anti-oestrogenic and oestrogelike action of clomiphene citrate. Animal Experiments
267. Stimulation of ovulation in pseudo-pregnant rats by clomiphene and related compounds
268. A comparison of the effects of clomiphene and tamoxifen treatment on the concentrations of oestradiol and progesterone in the peripheral plasma of infertile women
269. Endocrine consequences of continuous anti-estrogen therapy with Tamoxifen in premenopausal women
270. Effects of a single injection of an estrogen antagonist on the estrous cycle of the rat
271. Effect of clomid, sexovid and prostaglandins on induction of ovulation and gonadotropin secretion in a freshwater catfish, Heteropneustes Fossilis
272. Seasonal fluctuation in lipid and cholesterol content of ovary, liver and blood serum in relation to annual sexual cycle in Heteropneustes Fossilis
273. Effect of some triphenylethylenes on oestradiol binding in vitro to macromolecules from uterus and anterior pituitary
274. Action of MER-25 and of clomiphene on the human ovary
275. Effects of clomiphene on aromatization of steroids by the human placenta in vitro
276. Effect of cis and trans isomers of clomiphene on reproductive perfomance in ewes
277. The effect of cis- and trans-clomiphene citrate on the collagen content of fetal bone
278. Effect of clomiphene on blastocyst nidation in the rat
279. Effect of cis- and trans-clomiphene on the uterine blood flow of oophorectomized ewes
280. Tamoxifen is a potent pure anti-oestrogen in chick oviduct
281. Cellular degradation of developing central nervous system of rats produced by hypocholesterolemic drug AY-9944
282. Ultrastructural study of neuronal cytoplasmic inclusions produced by hypocholesterolemic drug AY-9944
283. Effects of triparanol and 20,25-diazacholesterol in CNS of rat: morphological and biochemical studies
284. Neonatal effect of clomiphene and O,P′-DDT on hepatic oxidative metabolism of male rats
285. High doses of estrogens do not interfere with the ovulation-inducing effect of clomiphene citrate
286. Clomiphene citrate for ovulation induction
287. Evaluation of anovulatory cycles and induction of ovulation
288. Structure-activity relationships of anti-oestrogens with regard to interaction with 17 beta-oestradiol in the mouse uterus and vagina
289. Aspects on the mode of action of anti-estrogens and anti-progestogens
290. Positive feedback effects of estrogen in amenorrheic women
291. The effects of clomiphene citrate in patients with pituitary-gonadal disorders
292. Studies on the effect of clomiphene citrate (Clomid) on female reproductive function. I. Animal Experiment
293. Effects of MRL-41 in human male and female fertility studies
294. New evidence for an anti-estrogenic action of clomiphene citrate in women
295. Treatment of infertility in Macaca Mulatta with clomiphene citrate
296. The anti-estrogenic effect of clomiphene in the human being
297. Effect of anti-estrogenic action of clomiphene during the menstrual cycle: evidence for a change in the feedback sensitivity
298. The normal development of the blood testis barrier and the effects of clomiphene and estrogen treatment
299. Triparanol induced cataract in rats
300. Anti-estrogen effects on estrogen accumulation in brain cell nuclei: neurochemical correlates of estrogen action on female sexual behavior in guinea pigs
301. Inhibitory and facilitatory effects on various anti-estrogens on the induction of female sexual behavior by estradiol benzoate in guinea pigs
302. Induction of ovulation in rhesus monkeys: a comparative study
303. Direct inhibitory effect of enclomiphene citrate and estradiol on testis functions in hypophysectomized rats
304. Biological properties of three ovulation inducers: Stillboestrol, Clomiphene and F6066
305. Reproductive defects and abnormal progency of rats treated with triparanol: prevention of abnormalities by ACTH
306. Estrogen-progesterone interactions in uterus and brain of intact and adrenalectomized immature and adult rats
307. Clomiphene citrate: its uses in infertility
308. Clomiphene citrate: experience with 217 patients. Variation in response and unusual reactions
309. Studies on the role of sex steroids in the feedback control of gonadotropin concentrations in men. II. Use of the estrogen antagonist, clomiphene citrate
310. Estrogenic and anti-estrogenic effects of clomiphene, MER-25 and CN-55, 945-27 on the rat uterus and vagina
311. Oestrogen responses of rats neonatally sterilized with steroids
312. Plasma hormones in clomiphene citrate therapy
313. Estrogen induction of ornithine aminotransferase in rat kidney slices
314. Inhibition of uterine receptor binding of estradiol by anti-estrogens (Clomiphene and CL-868)
315. Effects of an ovulation-inducing agent, clomiphene citrate, on cultured human fetal cells
316. Effect of clomiphene citrate in polycystic ovary syndrome: relationship between serum gonadotropin and corpus luteum function
317. Ultradian fluctuations of gonadotropins
318. Congenital anomalies and clomiphene
319. Effect of hypocholesterolemic drug AY-9944 and cultured nervous tissue: Morphologic and biochemical studies
320. Impairment of anterior pituitary functions by follicular hormone