Sustained-release theophylline for childhood asthma: Evidence for circadian variation of theophylline pharmacokinetics

The Journal of Pediatrics

Volumn 99, Issue 3, 1981, Pages 476-479

  Scott, Peter H ^a   Tabachnik, Elvan ^b   MacLeod, Stuart ^b   Correia, Junita ^b   Newth, Christopher ^b   Levison, Henry ^b  

^a RILEY HOSPITAL FOR CHILDREN   (United States)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPHYLLINE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CHOLINE THEOPHYLLINATE; CROMOGLYCATE DISODIUM; ERYTHROMYCIN; THEOPHYLLINE;

ASTHMA; CHILDHOOD; CIRCADIAN RHYTHM; DRUG BLOOD LEVEL; MAJOR CLINICAL STUDY; PHARMACOKINETICS; RESPIRATORY SYSTEM; THERAPY;

ADOLESCENT; ASTHMA; CHILD; CIRCADIAN RHYTHM; DELAYED-ACTION PREPARATIONS; FEMALE; HUMANS; KINETICS; MALE; THEOPHYLLINE;

EID: 0019517894     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-3476(81)80354-X     Document Type: Article

References (10)

1. Evaluation of oral bronchodilator therapy in asthematic children
2. Compliance differences following administration of theophylline at six- and twelve-hour intervals
3. Sustained-release theophylline therapy for chronic childhood asthma
4. Bioavailability and efficacy of a sustained-release theophylline tablet
5. Pharmacokinetic analysis of the disposition of intravenous theophylline in young children
6. Influence of diet and fluid on bioavailability of theophylline
7. Circadian variation in the susceptibility of rodents to the toxic effects of theophylline
8. Efficacy of a 12-hour sustained-release preparation in maintaining therapeutic serum theophylline levels in asthmatic children
9. Temporal variations in trough serum theophylline concentrations at steady state