Pulmonary Sarcoidosis: A Disorder Mediated by Excess Helper T-Lymphocyte Activity at Sites of Disease Activity

New England Journal of Medicine

Volumn 305, Issue 8, 1981, Pages 429-434

  Hunninghake, Gary W ^a   Crystal, Ronald G ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD AND HEMOPOIETIC SYSTEM; HELPER CELL; LUNG SARCOIDOSIS; MAJOR CLINICAL STUDY; RESPIRATORY SYSTEM;

EID: 0019510394     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198108203050804     Document Type: Article

References (33)

1. Mitchell D.N., Scadding J.G. Sarcoidosis. Am Rev Respir Dis. 1974; 110:774-802.
2. Rosen Y., Athanassiades T.J., Moon S., Lyons H.A. Nongranulomatous interstitial pneumonitis in sarcoidosis: relationship to development of epithelioid granulomas. Chest. 1978; 74:122-125
3. Carrington C.B., Gaensler E.A., Mikus J.P., Schacter A.W., Burke G.W., Goff A.M. Structure and function in sarcoidosis. Ann NY Acad Sci. 1976; 278:265-283
4. Hunninghake G.W., Gadek J.E., Kawanami O., Ferrans V.J., Crystal R.G. Inflammatory and immune processes in the human lung in health and in disease. Evaluation by bronchoalveolar lavage. Am J Pathol. 1979; 97:149-206.
5. Hunninghake G.W., Gadek J.E., Young R.C. Jr., Kawanami O., Ferrans V.J., Crystal R.G. Maintenance of granuloma formation in pulmonary sarcoidosis by T lymphocytes within the lung. N Engl J Med. 1980; 302:594-598
6. Hunninghake G.W., Fulmer J.D., Young R.C., Gadek J.E., Crystal R.G. Localization of the immune response in sarcoidosis. Am Rev Respir Dis. 1979; 120:49-57.
7. Hunninghake G.W., Kawanami O., Ferrans V.J., Young R.C., Roberts W.C., Crystal R.G. Characterization of the inflammatory and immune effector cells in the lung parenchyma of patients with interstitial lung disease. Am Rev Respir Dis. 1981; 123:407-412
8. Crystal R.G., Roberts W.C., Hunninghake G.W., Gadek J.E., Fulmer J.D., Line B.R. Pulmonary sarcoidosis: a disease characterized and perpetuated by activated lung T-lymphocytes. Ann Intern Med. 1981; 94:73-94.
9. Daniele R.P., Dauber J.H., Rossman M.D. Immunologic abnormalities in sarcoidosis. Ann Intern Med. 1980; 92:406-416
10. Gupta R.C., Kueppers F., DeRemee R.A., Huston K.A., McDuffie F.C. Pulmonary and extrapulmonary sarcoidosis in relation to circulating immune complexes: a quantification of immune complexes by two radioimmunoassays. Am Rev Respir Dis. 1977; 116:261-266
11. Hedfors E., Norberg R. Evidence for circulating immune complexes in sarcoidosis. Clin Exp Immunol. 1974; 16:493-496
12. Oreskes I., Siltzbach L.E. Changes in rheumatoid factor activity during the course of sarcoidosis. Am J Med. 1968; 44:60-67
13. Hirshaut Y., Glade P., Vieira L.O.B.D., Ainbender E., Dvorak B., Siltzbach L.E. Sarcoidosis, another disease associated with serologic evidence for herpes-like virus infection. N Engl J Med. 1970; 283:502-506
14. Daniele R.P., McMillan L.J., Dauber J.H., Rossman M.D. Immune complexes in sarcoidosis: a correlation with activity and duration of disease. Chest. 1978; 74:261-264
15. Daniele R.P., Rowlands D.T. Antibodies to T cells in sarcoidosis. Ann NY Acad Sci. 1976; 278:88-100.
16. Hunninghake G.W., Crystal R.G. Mechanisms of hypergammaglobulinemia in pulmonary sarcoidosis: site of increased antibody production and role of T-lymphocytes. J Clin Invest. 1981; 67:86-92.
17. Hunninghake G.W., Keogh B.A., Line B.R., et al. Pulmonary sarcoidosis: pathogenesis and therapy. In: Boros D, Yoshida T, eds. Basic and clinical aspects of granulomatous disease. New York: Elsevier North Holland, 1981: 275-90.
18. Kung P.C., Goldstein G., Reinherz E.L., Schlossman S.F. Monoclonal antibodies defining distinctive human T-cell surface antigens. Science. 1979; 206:347-349
19. Reinherz E.L., Kung P.C., Goldstein G., Schlossman S.F. A monoclonal antibody with selective reactivity with functionally mature human thymocytes and all peripheral human T cells. J Immunol. 1979; 123:1312-1317
20. Reinherz. Separation of functional subsets of human T cells by a monoclonal antibody. Proc Natl Acad Sci USA. 1979; 76:4061-4065
21. Reinherz. Further characterization of the human inducer T cell subset defined by monoclonal antibody. J Immunol. 1979; 123:2894-2896
22. Reinherz. A monoclonal antibody reactive with the human cytotoxic/suppressor T cell subset previously defined by a heteroantiserum termed TH2. J Immunol. 1980; 124:1301-1307
23. Reinherz E.L., Schlossman S.F. Regulation of the immune response—inducer and suppressor T-lymphocyte subsets in human beings. N Engl J Med. 1980; 303:370-373
24. Reinherz E.L., Kung P.C., Breard J.M., Goldstein G., Schlossman S.F. T cell requirements for generation of helper factor(s) in man: analysis of the subsets involved. J Immunol. 1980; 124:1883-1887
25. Reinherz E.L., Rubinstein A., Geha R.S., Strelkauskas A.J., Rosen F.S., Schlossman S.F. Abnormalities of immunoregulatory T cells in disorders of immune function. N Engl J Med. 1979; 301:1018-1022
26. Reinherz E.L., Parkman R., Rappeport J., Rosen F.S., Schlossman S.F. Aberrations of suppressor T cells in human graft-versus-host disease. N Engl J Med. 1979; 300:1061-1068
27. Keogh B., Hunninghake G., Line B., Price D., Young R., Crystal R. Therapy decisions in sarcoidosis: prospective use of bronchoalveolar lavage and gallium-67 scanning. Am Rev Respir Dis. 1980; 121:155A. abstract.
28. Keogh. Alveolitis parameters as predictors of the natural history of pulmonary sarcoidosis. Clin Res. 1981; 29:447A. abstract.
29. Line B.R., Fulmer J.D., Reynolds H.Y., et al. Gallium-67 citrate scanning in the staging of idiopathic pulmonary fibrosis: correlation with physiologic and morphologic features, and bronchoalveolar lavage. Am Rev Respir Dis. 1978; 118:355-365
30. Line B.R., Hunninghake G.W., Keogh B.A., Jones A.E., Johnston G.S., Crystal R.G. Gallium-67 scanning to stage the alveolitis of sarcoidosis: correlation with clinical studies, pulmonary function studies, and bronchoalveolar lavage. Am Rev Respir Dis. 1981; 123:440-446
31. Crystal R.G., Fulmer J.D., Roberts W.C., Moss M.L., Line B.R., Reynolds H.Y. Idiopathic pulmonary fibrosis: clinical, histologic, radiographic, physiologic, scintigraphic, cytologic, and biochemical aspects. Ann Intern Med. 1976; 85:769-788
32. Fulmer J.D., Roberts W.C., von Gal E.R., Crystal R.G. Morphologic-physiologic correlates of the severity of fibrosis and degree of cellularity in idiopathic pulmonary fibrosis. J Clin Invest. 1979; 63:665-676
33. Böyum A. Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Invest. 1968; 21: Suppl 97:77-89.