Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects

British Medical Journal (Clinical research ed.)

Volumn 282, Issue 6275, 1981, Pages 1509-1511

  Laurence, K M ^a   James, Nansi ^a   Miller, Mary H ^a   Tennant, G B ^a   Campbell, H ^a  

^a CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; PLACEBO;

CLINICAL TRIAL; CONGENITAL DISORDER; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG THERAPY; FETUS; HUMAN; HUMAN CELL; NEURAL TUBE DEFECT; PREGNANCY; PREMEDICATION; PREVENTION; RANDOMIZED CONTROLLED TRIAL; THERAPY;

CLINICAL TRIALS; DIET; DOUBLE-BLIND METHOD; FEMALE; FERTILIZATION; FOLIC ACID; HUMANS; NEURAL TUBE DEFECTS; PREGNANCY; RANDOM ALLOCATION; RECURRENCE;

EID: 0019476413     PISSN: 02670623     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.282.6275.1509     Document Type: Article

References (13)

1. Bradshaw J, Weale J, Weatherall J. Congenital malformation of the central nervous system. Population Trends 1980;19:13-18.
2. Laurence K.M. Prevention and prenatal diagnosis of neural tube defects. In: Persaud T.V., ed. Advances in the study of birth defects. Vol 7. Lancaster: MTS Press (in press).
3. Record R.G., McKeown T. Congenital malformations of the central nervous system. I. Survey of 930 cases. British Journal of Preventive and Social Medicine 1949;3:183-219.
4. Laurence K.M., Carter C.O., David P.A. The major central nervous system malformations in South Wales. II. Pregnancy factors, seasonal variations and social class effects. British Journal of Preventive and Social Medicine 1968;22:212-22.
5. Smithells R.W., Sheppard S., Schorah C.J. Nutritional deficiencies and neural tube defects. Arch Dis Child 1976;51:944-50.
6. Hibbard E.D., Smithells R.W. Folic acid metabolism and human embryopathy. Lancet 1965;i:1254.
7. Thiersch J.B. Therapeutic abortions with folic acid antagonist, 4-aminopteroylglutamic acid (4 amino PGA) administered by oral route. Am J Obstet Gynecol 1952;63:1298-1304.
8. Laurence K.M., Carter C.O., David P.A. The major central nervous system malformations in South Wales. I. Incidence, local variation and geographical factors. British Journal of Preventive and Social Medicine 1968;22:146-160.
9. Richards I.D.G. Congenital defects in South Wales. PhD thesis. University of Wales, 1971.
10. Laurence K.M., James N, Miller M, Campbell H. The increased risk of recurrence of neural tube defects to mothers on poor diets and the possible benefit of dietary counselling. Br Med J 1980;281:1542-4.
11. Tennant G.B., Withey J.L. An assessment of work simplified procedures for the microbiological array of serum vitamin B12 and serum folate. Medical Laboratory Technology 1972;29:171-81.
12. Hoffbrand A.V., Newcombe B.F.A., Mollin D.L. Method of assay of red cell folate activity and the value of the assay as a test for folate deficiency. J Clin Pathol 1966;19:17-28.
13. Smithells R.W., Sheppard S., Schorah C.J., et al. Possible prevention of neural tube defects by preconceptional vitamin supplementation. Lancet 1980;i:339-40.