Synthesis and Evaluation of 1,2,3,4-Tetrahydro[1]benzothieno[2,3-h]isoquinolines as Dopamine Antagonists

Journal of Medicinal Chemistry

Volumn 24, Issue 9, 1981, Pages 1107-1110

  Ellefson, Charles R ^a   Prodan, Kathleen A ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT;

1,2,3,4 TETRAHYDRO[1]BENZOTHIENO[2,3 H]ISOQUINOLINE DERIVATIVE; AVOIDANCE BEHAVIOR; DOPAMINE H 3; DRUG SYNTHESIS; HALOPERIDOL H 3;

ANIMAL; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; CHEMISTRY; DOPAMINE ANTAGONISTS; ISOQUINOLINES; RATS; THIOPHENES;

EID: 0019466746     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00141a021     Document Type: Article

References (7)

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6. These were dopamine receptor binding studies, conditioned avoidance response in trained rat (CAR), LD50, and relative CNS activity as evaluated in a battery of 16 standard assays. Activities observed in the CNS battery are abbreviated in Table I as follows: Ma, antagonism of minimal electroshock seizures; St, antagonism of strychnine-induced seizures; He, potentiation of barbiturate sleeping time; Ho, analgesia (hotplate test); Ta, analgesia (tail-clip test); Ro, rotating-rod test for motor coordination; Mo, antagonism of morphine-induced analgesia; Am, inhibition of amphetamine-induced lethality; Se, antagonism of serotonin-induced diarrhea; Me, antagonism of metrazole-induced seizures.
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