How to break the Logjam in Schizophrenia A look beyond Genetics

Journal of Nervous and Mental Disease

Volumn 169, Issue 8, 1981, Pages 477-492

  Zubin, Joseph ^a   Steinhauer, Stuart ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MODEL; CENTRAL NERVOUS SYSTEM; DEVELOPMENT; ETIOLOGY; HEREDITY; INHERITANCE; LEARNING; MIGRATION; NEUROPHYSIOLOGY; SCHIZOPHRENIA; SHORT SURVEY;

GENOTYPE; HUMAN; MODELS, NEUROLOGICAL; MODELS, PSYCHOLOGICAL; RESEARCH; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SUPPORT, U.S. GOV'T, NON-P.H.S.;

EID: 0019416276     PISSN: 00223018     EISSN: 1539736X     Source Type: Journal    
DOI: 10.1097/00005053-198108000-00002     Document Type: Article

References (82)

1. American Psychiatric Association Task Force on Nomenclature and Statistics. Diagnostic and Statistical Manual of Mental Disorders, 3rd Ed. American Psychiatric Association, Washington, D.C., 1979.
2. Audy, J. R. Measurement of diagnosis of health. In Shepard, R., and McKinley, D., Eds., Environmental. Houghton Mifflin, Boston, 1971.
3. Bellissimo, A., and Steffy, R. A. Redundancy-associated deficit in schizophrenic reaction time performance. J. Abnorm. Psychol., 80: 299-307, 1972.
4. Bland, R. C, Parker, J. H., and Orn, H. Prognosis in schizophrenia. Arch. Gen. Psychiatry, 35: 72-80, 1978.
5. Bleuler, M. The long-term course of schizophrenic psychosis. In Wynne, L. C, Cromwell, R. L., and Matthysse, S., Eds., The Nature of Schizophrenia: New Approaches to Research and Treatment, pp. 631-636. John Wiley & Sons, New York, 1979.
6. Brown, G. W., and Bhiey, J. L. T. Crises and life changes and the onset of schizophrenia. J. Health Soc. Behav., 9: 203-214, 1968.
7. Brown, G. W., and Harris, T. Social Origins of Depression. Free Press, New York, 1978.
8. Buck, C, and Simpson, H. Season of birth among siblings of schizophrenics. Br. J. Psychiatry, 132: 358-360, 1978.
9. Cancro, R., vanGelder, P., and Glazer, W. Visual attention in hospitalized schizophrenic patients. Psychopharmacol. Bull., 15: 21-22, 1979.
10. Cazzullo, C. L., Smeraldi, E., and Penati, G. The leukocyte antigenic system HL-A as a possible genetic marker of schizophrenia. Br. J. Psychiatry, 125: 25-27, 1974.
11. Cooper, J. E., Kendell, R. E., Gorland, B. J., et al. Psychiatric Diagnosis in New York and London: A Comparative Study of Mental Health Admissions (Maudsley Monograph No. 20). Oxford University Press, London, 1972.
12. Dohrenwend, B. S., and Dohrenwend, B. P. Some issues in research on stressful life events. J. Nerv. Ment. Dis., 166: 7-15, 1978.
13. Eberhard, G., Franzen, G., and Low, B. Schizophrenia susceptibility and HL-A antigen. Neuropsychobiology, 1: 211-217, 1975.
14. Falconer, D. S. The inheritance of liability to certain diseases, estimated from the incidence among relatives. Ann. Hum. Genet., 29: 51-76, 1965.
15. Fischer, M. Psychoses in the offspring of schizophrenic mono-zygotic twins and their normal cotwins. Br. J. Psychiatry, 118: 43-52, 1971.
16. Goldfried, M. R., and D'Zurilla, T. J. A behavioranalytic model for assessing competence. In Spielberger, C. D., Ed., Current Topics in Clinical and Community Psychology, Vol. 1, pp. 151-196. Academic Press, New York, 1969.
17. Goldsmith, J. B., and McFall, R. M. Development and evalua-tion of an interpersonal skill-training program for psychiatric inpatients. J. Abnorm. Psychol., 84: 51-58, 1975.
18. Goldstein, M. J., Rodnick, E. H., Jones, J. E., et al. Familial precursors of schizophrenia spectrum disorders. In Wynne, L. C, Cromwell, R. L., and Matthysse, S., Eds., The Nature of Schizophrenia: New Approaches to Research and Treatment, pp. 487-498. John Wiley & Sons, New York, 1978.
19. Gottschalk, L. A. Vulnerability to mental disorders as adjudged from form and content speech samples. Psychopharmacol. Bull., 15: 25-26, 1979.
20. Hammer, M., Makiesky-Barrow, S., and Gutwirth, L. Social networks and schizophrenia. Schizophr. Bull., 4: 522-545, 1978.
21. Hardesty, A. S., and Burdock, E. I. Psychometric markers of vulnerability in children and adults. Psychopharmacol. Bull., 15: 14-20, 1979.
22. Hare, H. E. Season of birth in schizophrenia and neuroses. Am. J. Psychiatry, 132: 1168-1171, 1975.
23. Heston, L. L. Psychiatric disorders in foster home reared children of schizophrenic mothers. Br. J. Psychiatry, 112: 819-835, 1976.
24. Holmes, T. H., and Rahe, R. H. The social readjustment rating scale. J. Psychosom. Res., 11: 213-218, 1967.
25. Holzman, P. S. Smooth pursuit eye movements as an indicator of vulnerability. Psychopharmacol. Bull., 15: 22-23, 1979.
26. Ingvar, D. H., and Franzen, G. Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia. Acta Psychiatr. Scand., 50: 425-462, 1974.
27. Janowsky, D. S., Davis, J. M., Huey, L., and Judd, L. L. Adrenergic and cholinergic drugs as episode and vulnerability markers of affective disorders and schizophrenia. Psychopharmacol. Bull., 15: 33-34, 1979.
28. John, V. Intellectual development of slum children. Am. J. Orthopsychiatry, 33: 813-822, 1963.
29. Kety, S. S. Introduction: Section II. Biochemical approaches. In Wynne, L. C, Cromwell, R. L., and Matthysse, S., Eds., The Nature of Schizophrenia: New Approaches to Research and Treatment, pp. 85-86. John Wiley & Sons, New York, 1978.
30. Kety, S. S., Rosenthal, D., Wender, P. H., and Schulsinger, F. The types and prevalence of mental illness in the biological and adoptive families of adopted schizophrenics. In Rosenthal, D., and Kety, S. S., Eds., The Transmission of Schizophrenia, pp. 345-362. Pergamon Press, London, 1968.
31. Kietzman, M. L., Spring, B., and Zubin, J. Perception, cognition and attention. In Kaplan, H. I., Freedman, A. M., and Sad-dock, B. W., Eds., Comprehensive Textbook of Psychiatry/ III, pp. 334-371. Williams & Wilkins, Baltimore, 1980.
32. Kinney, D. K., and Jacobson, B. Environmental factors in schizophrenia: New adoption study evidence. In Wynne, L. C, Cromwell, R. L., and Matthysse, S., Eds., The Nature of Schizophrenia: New Approaches to Research and Treatment, pp. 38-51. John Wiley & Sons, New York, 1978.
33. Kornetsky, C, and Orzack, M. H. Physiological and biological correlates of attention dysfunction in schizophrenic patients. J. Psychiatr. Res., 14: 69-79, 1978.
34. Kreisman, D. Social interaction and intimacy in preschizophrenic adolescence. In Zubin, J., and Freedman, A. M., Eds., The Psychopathology of Adolescence, pp. 299-318. Grune & Stratton, New York, 1970.
35. Kupfer, D. J. REM latency: A psychobiologic marker for primary depressive disease. Biol. Psychiatry, 11: 159-174, 1976.
36. Kupfer, D. J., and Foster, F. G. The sleep of psychotic patients: Does it all look alike? In Freedman, D. X., Ed., Biology of Major Psychoses: A Comparative Analysis, pp. 143-159. Raven Press, New York, 1975.
37. Kupfer, D. J., Weiss, B. L., Foster, F. G., et al. Psychomotor activity in affective states. Arch. Gen. Psychiatry, 30: 765-768, 1974.
38. Leff, J. P. Assessment of drugs in schizophrenia. Br. J. Clin. Pharmacol., Suppl.: 75-78, 1976.
39. Levit, R., Sutton, S., and Zubin, J. Evoked potential correlates of information processing in psychiatric patients. Psychol. Med., 3: 487-494, 1973.
40. Luborsky, L., and Auerbach, A. The symptom-context method: Quantitative studies of symptom formation in psychotherapy. J. Am. Psychoanal. Assoc., 17: 68-69, 1969.
41. Meltzer, H. Y. Neuromuscular dysfunction in schizophrenia. Schizophr. Bull., 2: 106-135, 1976.
42. Pasamanick, B. Epidemiological investigation of some prenatal factors in the production of neuropsychiatric disorders. In Hoch, P. H., and Zubin, J., Eds., Comparative Epidemiology of Mental Disorders, pp. 260-275. Grune & Stratton, New York, 1961.
43. Pattison, E. M., deFrancisco, D., Wood, P., et al. A psychosocial kinship model for family therapy. Am. J. Psychiatry, 132: 1246-1251, 1975.
44. Paul, G. L., and Lentz, R. J. Psychosocial Treatment of Chronic Mental Patients: Milieu Versus Social-Learning Programs. Harvard University Press, Cambridge, Mass., 1977.
45. Post, R. M., Fink, E., Carpenter, W. T., and Goodwin, F. K. Cerebrospinal fluid amine metabolites in acute schizophrenia. Arch. Gen. Psychiatry, 32: 1063-1069, 1975.
46. Powell, G. F., Brasil, J. A., and Blizzard, R. M. Emotional deprivation and growth retardation simulating idiopathic hypopituitarism. I. Clinical evaluation of the syndrome. N. Engl. J. Med., 276: 1271-1278, 1967.
47. Rabkin, J. G. Stressful life events and schizophrenia: A review of the research literature. Psychol. Bull., 87: 408-425, 1980.
48. Rahe, R. H., Meyers, M., Smith, M., et al. Social stress and illness onset. J. Psychosom. Res., 8: 35-44, 1964.
49. Rodnick, E., and Shakow, D. Set in the schizophrenic as mea-sured by a composite reaction time index. Am. J. Psychiatry, 97: 214-225, 1940.
50. Rosenzweig, M. R. Environmental complexity, cerebral change and behavior. Am. Psychol., 21: 321-332, 1966.
51. Rubin, L. S. The utilization of pupillometry in the differential diagnosis and treatment of psychotic and behavioral disor-ders. In Janisse, M. P., Ed., Pupillary Dynamics and Behavior, pp. 75-134. Plenum Publishing Corp., New York, 1974.
52. Sachar, E. J., Mackenzie, J. M., Binsback, W. A., and Mack, J. E. Corticosteroid responses to the psychotherapy of reactive depressions. II. Further clinical and physiological implications. Psychosom. Med., 30: 23-44, 1968.
53. Salzinger, K. Schizophrenia: Behavioral Aspects. John Wiley & Sons, New York, 1973.
54. Schmale, A. H. Giving up as a final common pathway to changes in health. Adv. Psychosom. Med., 8: 20-40, 1972.
55. Shagass, C. Possible contributions of evoked potentials to the vulnerability hypothesis. Psychopharmacol. Bull., 75: 34-35, 1979.
56. Shapiro, R. W., Bock, E., Rafaelson, O. J., et al. Histocompatibility antigens and manic-depressive disorders. Arch. Gen. Psychiatry, 33: 823-825, 1976.
57. Singer, M. T., Wynne, L. C, and Toohey, M. L. Communication disorders and the families of schizophrenics. In Wynne, L. C, Cromwell, R. L., and Matthysse, S., Eds., The Nature of Schizophrenia: New Approaches to Research and Treatment, pp. 499-511. John Wiley & Sons, New York, 1978.
58. Smeraldi, E., Bellodi, L., Scorza-Smeraldi, R., et al. HLA-SD antigens and schizophrenia: Statistical and genetical considerations. Tissue Antigens, 8: 191-196, 1976.
59. Sneath, P. H. A., and Sokal, R. R. Numerical Taxonomy: The Principles and Practice of Numerical Classification. W. H. Freeman & Co., San Francisco, 1973.
60. Sokolovsky, J., Cohen, C, Berger, D., and Geiger, J. Personal networks of exmental patients in a Manhattan S.R.O. hotel. Hum. Organization, 37: 5-15, 1978.
61. Spitzer, R. L., Endicott, J., and Robins, E. Research diagnostic criteria: Rationale and reliability. Arch. Gen. Psychiatry, 35: 773-782, 1978.
62. Spohn, H. E., and Patterson, T. Recent studies of psychophysiology in schizophrenia. Schizophr. Bull., 5: 581-611, 1979.
63. Spring, B., and Coon, H. Stress as a precursor of schizophrenic episodes. In Neufeld, W. J., Ed., Psychological Stress and Psychopathology. McGraw-Hill, New York. In press.
64. Steinhauer, S. R., Hakerem, G., and Spring, B. The pupillary response as a potential indicator of vulnerability to schizophrenia. Psychopharmacol. Bull., 15: 44-45, 1979.
65. Sutton, S., Hakerem, G., Zubin, J., and Portnoy, M. The effect of shift of sensory modality on serial reaction time: A comparison of schizophrenics and normals. Am. J. Psychol., 74: 224-232, 1961.
66. Sutton, S., Spring, B. J., and Tueting, P. Modality shift at the crossroads. In Wynne, L. C, Cromwell, R. L., and Matthysse, S., Eds., The Nature of Schizophrenia: New Approaches to Research and Treatment, pp. 262-269. John Wiley & Sons, New York, 1978.
67. Sutton, S., and Tueting, P. Evoked potentials and diagnosis. In Spitzer, R., and Klein, K., Eds., Critical Issues in Psychiatric Diagnosis, pp. 265-279. Raven Press, New York, 1978.
68. Tolsdorf, C. C. Social networks, support and coping: An exploratory study. Fam. Process, 15: 407-418, 1976.
69. Torrey, E. F. Bleak at best. In Brady, J. P., and Brodie, H. K. H., Eds., Controversy in Psychiatry, pp. 3-12. W. B. Saunders, Philadelphia, 1978.
70. Waldbaum, J. K., Sutton, S., and Kerr, J. Shifts in sensory modality and reaction time in schizophrenia. In Kietzman, M. L., Sutton, S., and Zubin, J., Eds., Experimental Approaches to Psychopathology, pp. 167-176. Academic Press, New York, 1975.
71. Weinberger, D. R., and Wyatt, R. J. Structural brain abnormalities in chronic schizophrenia: Computed tomography findings. In Baxter, C, and Melnechuk, I., Eds., Perspectives in Schizophrenia Research, pp. 29-41. Raven Press, New York, 1980.
72. Weiner, H. Psychobiology and Human Disease, pp. 624-638. Elsevier, New York, 1977.
73. Weissman, M. The assessment of social adjustment: A review of technique. Arch. Gen. Psychiatry, 32: 357-365, 1975.
74. Wing, J. K. Five year outcome in early schizophrenia. Proc. R. Soc. Med., 59: 17-18, 1966.
75. World Health Organization. Report of the International Pilot Study of Schizophrenia, Vol. 1. World Health Organization, Geneva, 1973.
76. Zahn, T. P., Carpenter, W. T., Jr., and McGlashan, T. H. Autonomic variables related to short-term outcome and clinical improvement in acute schizophrenia. Psychopharmacol. Bull., 15: 42, 1979.
77. Zubin, J. Chronic schizophrenia from the standpoint of vulnerability. In Baxter, C. F., and Melenchuck, I., Eds., Perspectives in Schizophrenia Research, pp. 269-294. Raven Press, New York, 1980.
78. Zubin, J., Chairman. Markers of vulnerability to mental disorders. Psychopharmacol. Bull., 15: 7-49, 1979.
79. Zubin, J. Scientific models for psychopathology in the '70s. Semin. Psychiatry, 40: 283-296, 1972.
80. Zubin, J. Summary of session: Markers of vulnerability to mental disorders. Psychopharmacol. Bull., 15: 47-49, 1979.
81. Zubin, J., and Burdock, E. I. The revolution in psychopathology and its implications for public health. Acta Psychiatr. Scand., 41: 348-359, 1965.
82. Zubin, J., and Spring, B. Vulnerability-A new view of schizophrenia. J. Abnorm. Psychol, 86: 103-126, 1977.