Enhanced thromboxane A2 and prostacyclin production by cultured rectal mucosa in ulcerative colitis and its inhibition by steroids and sulfasalazine

Gastroenterology

Volumn 81, Issue 3, 1981, Pages 444-449

  Ligumsky, Moshe ^a,b   Karmeli, Fanny ^a,b   Sharon, Pinchas ^a,b   Zor, Uriel ^a,b   Cohen, Fortune ^a,b   Rachmilewitz, Daniel ^a,b  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; AZATHIOPRINE; CORTICOSTEROID; CROMOGLYCATE DISODIUM; FLUFENAMIC ACID; METHYLPREDNISOLONE; PROSTACYCLIN; PROSTAGLANDIN; PROSTAGLANDIN E2; SALAZOSULFAPYRIDINE; SALICYLIC ACID; SULFAPYRIDINE; THROMBOXANE; THROMBOXANE A2; PROSTAGLANDIN E; STEROID;

3 AMINOSALICYLIC ACID; CELL CULTURE; DIGESTIVE SYSTEM; ETIOLOGY; HUMAN CELL; IN VITRO STUDY; INTESTINE MUCOSA; LARGE INTESTINE; PATHOPHYSIOLOGY; RECTUM; RECTUM MUCOSA; ULCERATIVE COLITIS; ARTICLE; BIOSYNTHESIS; DRUG EFFECT; HUMAN; METABOLISM; MUCOSA;

COLITIS, ULCERATIVE; EPOPROSTENOL; HUMAN; IN VITRO; MUCOUS MEMBRANE; PROSTAGLANDINS; PROSTAGLANDINS E; RECTUM; STEROIDS; SULFASALAZINE; SUPPORT, NON-U.S. GOV'T; THROMBOXANE A2; THROMBOXANES;

EID: 0019395514     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/0016-5085(81)90594-1     Document Type: Article

References (25)

1. Role of prostaglandins in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine
2. Rectal mucosal prostaglandin E release and electrolyte transport in ulcerative colitis
3. Prostaglandin synthetase activity in acute ulcerative colitis: effects of treatment with sulphasalazine codeine phosphate and prednisolone
4. 1 on water and electrolyte absorption in the human jejunum
5. Prostaglandins and signs and symptoms of inflammation
6. Salicylate other than 5-amino salicylate acid ineffective in ulcerative colitis (lett)
7. Prostaglandins and ulcerative colitis (lett)
8. 2 from prostaglandin endoperoxides
9. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
10. Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides
11. The chemical structure of prostaglandin X (prostacyclin)
12. 2 and prostacyclin
13. A multipurpose instrument for suction biopsy of the esophagus, stomach, small bowel and rectum
14. Radioimmunological assay of prostaglandin synthetase activity
15. Protein measurement with the folin phenol reagent
16. Rectal mucosa prostacyclin formation in ulcerative colitis (lett)
17. Prostaglandins in colonic inflammation
18. Stimulation of intestinal mucosal adenyl cyclase by cholera enterotoxin and prostaglandins
19. Bile acid stimulation of colonic adenylate cyclase and secretion in the rabbit
20. Effects of sulphasalazine and its metabolites on prostaglandin synthesis inactivation and actions on smooth muscle
21. Mechanism of steroid action in inflammation; inhibition of prostaglandin synthesis and release
22. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
23. An experiment to determine the active therapeutic moiety of sulphasalazine
24. 2 (abstr)