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Tetrahedron Letters

Volumn 22, Issue 1, 1981, Pages 25-28

Synthesis of "9-deazaadenosine"; A new cytotoxic C-nucleoside isostere of adenosine

(2) Lim, Mu Ill a Klein, Robert S a

a MEMORIAL SLOAN KETTERING CANCER CENTER (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9 DEAZAADENOSINE; ANIMAL EXPERIMENT; BLOOD AND HEMOPOIETIC SYSTEM; DRUG ANALYSIS; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SYNTHESIS; HUMAN CELL; IN VITRO STUDY; LEUKEMIA; MASS; MOUSE; NUCLEAR MAGNETIC RESONANCE; THEORETICAL STUDY;

EID: 0019365529 PISSN: 00404039 EISSN: None Source Type: Journal
DOI: 10.1016/0040-4039(81)80031-7 Document Type: Article

Times cited : (106)

References (17)

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2
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3
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- Bloch¹

4
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5
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6
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- De Roos¹ Salemink²

7
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- Synthetic studies of potential antimetabolites. XIII. Synthesis of 7-amino-3-β-d-ribofuranosyl-3H-imidazo[4,5-b] pyridine (1-deazaadenosine) and related nucleosides
- (1972) Journal of Heterocyclic Chemistry , vol.9 , pp. 465
- Itoh¹ Kitano² Mizuno³

8
- 0013879698
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9
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10
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11
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12
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13
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- (1978) J. Org. Chem. , vol.43 , pp. 2923
- Still¹ Kahn² Mitra³

14
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- Criteria for determining the epimeric configuration at C-1 of several α- and β- C-nucleoside pairs have been discussed in the following paper and in references therein:
- (1979) J. Org. Chem. , vol.44 , pp. 4854
- Tam¹ Klein² de las Heras³ Fox⁴

15
- 0003217791
- The Chemistry of Cyclic Enaminonitriles and O-Aminotriles
- For a review, see, Wiley-Interscience, New York, N. Y, Chapter VIII
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- Taylor¹ McKillop²

16
- 84914356481
- The authors are indebted to Dr. Joseph H. Burchenal of this Institute for the communication of these results.

17
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- All new compounds were characterized by their NMR spectra and elemental analysis supported in some instances by mass spectroscopic data.

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