Treatment of alcohol-related liver disease with (+)-cyanidanol-3: a randomised double-blind trial

Gut

Volumn 21, Issue 11, 1980, Pages 965-969

  Colman, J C ^a   Morgan, M Y ^a   Scheuer, P J ^a   Sherlock, S ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CATECHIN;

ADVERSE DRUG REACTION; ALCOHOL LIVER DISEASE; AMINOTRANSFERASE BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED STUDY; DRUG THERAPY; FEVER; HEPATITIS; HISTOLOGY; HUMAN; LIVER; LIVER BIOPSY; MAJOR CLINICAL STUDY; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL; THERAPY;

EID: 0019192727     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.21.11.965     Document Type: Article

References (19)

1. Lieber, C.S.; Rubin, E. Alcoholic fatty liver in man on a high protein and low fat diet Am J Med 1968 10.1016/0002-9343(68)90151-4 44 200
2. Rubin, E.; Lieber, C.S. Alcohol-induced hepatic injury in non-alcoholic volunteers N Engl J Med 1968 10.1056/NEJM196804182781602 278 869
3. Lieber, C.S. Alcohol and the liver The biological basis of medicine Vol 5 1965 317
4. Geokas, M.C.; Rinderknecht, H. Plasma arylsulfatase and P-glucuronidase in acute alcoholism Clin Chim Acta 1973 10.1016/0009-8981(73)90098-3 46 27
5. Bohm, K. Die Flavonoide 1967
6. Das, M.P.; Sothy, S.P. Studies on flavonoid metabolism Biochem J 1971 125 417
7. Cetta, G.; Gezzeli, G.; Quartieri, A.; Castellani, A. Protective effect of flavonoids on collagen or lathyritic rats Experientia 1971 10.1007/BF02138872 27 1046
8. Caneghem, P. Influence of some hydrosoluble substances with vitamin P activity on the fragility of lysosomes in vitro Biochem Pharmacol 1972 10.1016/0006-2952(72)90303-6 21 1543
9. Gajdos, A.; Gajdos-Torok, M.; Horn, R. Augmentation du taux hepatique de 1'ATP chez le rat blanc par administration de (+)-catechine. C R Soc Biol 1969; 163 2089
10. Blumenkrantz, N.; Asboe-Hansen, G. IRCS medical science: biochemistry, connective tissue, skin and bone 1975 3 573
11. Cetta, G.; Fossati, G.; Castellani, A.A. In vivo and in vitro evidence for the action of (+)-catechin and its derivatives on connective tissue 1974 140 trends in the therapy of liver diseases
12. Galizzi, J.; Morgan, M.Y.; Chitronukroh, A.; Sherlock, S. The detection of minimal alcoholic liver disease by three methods Scand J Gastroent 1978 10.3109/00365527809182198 13 827
13. Morgan, M.Y.; Camilo, M.E.; Luck, W.; Sherlock, S.; Hoffbrand, A.V. Macrocytosis in alcohol-related liver disease: its value for screening J Lab Clin Haem 1980
14. Nikkila, E.A.; Ojala, K. Role of hepatic L-oc-glycerophosphate and triglyceride synthesis in production of fatty liver by ethanol. Proc Soc Exp Biol Med 1963 113 814
15. Lieber, C.S.; Schmid, R. The effect of ethanol on fatty acid metabolism: stimulation of hepatic fatty acid synthesis in vitro J Clin Invest 1961 10.1172/JCI104266 40 394
16. Lieber, C.S.; Spritz, N.; De Carli, L.M. Fatty liver produced by dietary deficiencies: its pathogenesis and potentiation by ethanol JLipid Res 1969 283 10
17. Lieber, C.S.; Spritz, N. Effects of prolonged ethanol intake in man: role of dietary, adipose and endogenously synthesized fatty acids in the pathogenesis of the alcoholic fatty liver J Clin Invest 1966 10.1172/JCI105448 45 1400
18. Lieber, C.S.; Spritz, N.; De Carli, L.M. Role of dietary, adipose and endogenously synthesized fatty acids in the pathogenesis of the alcoholic fatty liver J Clin Invest 1966 10.1172/JCI105323 45 51
19. Mendenhall, C.L. Origin of hepatic triglyceride fatty acids: quantitative estimation of the relative contributions of linoleic acid by diet and adipose tissue in normal and ethanol fed rats J Lipid Res 1972 10.1016/S0022-2275(20)39410-4 13 177