Prolonged effects of large-dose methylprednisolone infusion in multiple sclerosis

Neurology

Volumn 30, Issue 7, 1980, Pages 702-708

  Trotter, John L ^a   Garvey, William F ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN M; METHYLPREDNISOLONE; RADIOISOTOPE;

B LYMPHOCYTE; BLOOD AND HEMOPOIETIC SYSTEM; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID IMMUNOGLOBULIN LEVEL; DRUG DOSE; DRUG THERAPY; ENDOCRINE SYSTEM; GRANULOCYTE; HYDROCORTISONE BLOOD LEVEL; INTRAVENOUS DRUG ADMINISTRATION; LYMPHATIC SYSTEM; LYMPHOCYTE; MAJOR CLINICAL STUDY; MULTIPLE SCLEROSIS; PERIPHERAL NERVOUS SYSTEM; T LYMPHOCYTE; THERAPY; THYMIDINE H 3;

B-LYMPHOCYTES; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HEMATOCRIT; HUMAN; HYDROCORTISONE; IMMUNOGLOBULIN G; LEUKOCYTE COUNT; LYMPHOCYTE ACTIVATION; MALE; METHYLPREDNISOLONE; MULTIPLE SCLEROSIS; SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTES; TIME FACTORS;

EID: 0018953704     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/wnl.30.7.702     Document Type: Article

References (24)

1. Coburg AJ, Gray SH, Katz FL, et al: Disappearance rates and immunosuppression of intermittent intravenously administered prednisolone in rabbits and human beings. Surg Gynecol Obstet 131:933-942, 1970
2. Bell PRF, Caiman KC, Wood RFM, et al: Reversal of acute clinical and experimental organ rejection using large doses of intravenous prednisolone. Lancet 1:876-880, 1971
3. Feduska NJ, Turcotte JG, Gikas PW, et al: Reversal of renal allograft rejection with intravenous methylprednisolone “pulse” therapy. J Surg Res 12:208-214, 1972
4. Cathcart ES, Scheinberg MA, Idelson BA, et al: Beneficial effects of methylprednisolone "pulse” therapy in diffuse proliferative lupus nephritis. Lancet 1:163-166, 1975
5. Fan PT, Yu DTY, Tangoff C, et al: Effect of corticosteroids on the human immune response. Transplantation 26:266267, 1978
6. Fan PT, Yu DTY, Clements PJ, et al: Effect of corticosteroids on the human immune response: Comparison of one and three daily 1 gram intravenous pulses of methylprednisolone. J Lab Clin Med 91:625-634, 1978
7. Rose AS, Kuzma JW, Kurtzke JF, et al: Cooperative study in the evaluation of therapy in multiple sclerosis: ACTH versus placebo. Neurology (Minneap) 20:1-59, 1970
8. Novak E, Stubbs SS, Seckman CE, et al: Effects of a single large intravenous dose of methylprednisolone sodium succinate. Clin Pharmacol Ther 11:711-717, 1970
9. Webel ML, Ritts RE, Taswell HF, et al: Cellular immunity after intravenous administration of methylprednisolone. J Lab Clin Med 83:383-392, 1974
10. Rose AS, Ellison GW, Myers LW: Criteria for the clinical diagnosis of multiple sclerosis. Neurology (Minneap) 26:20-25, 1976
11. Cook JD, Trotter JL, Engel WK, et al: The effects of singledose, alternate-day prednisone therapy on the immunological status of patients with neuromuscular diseases. Ann Neurol 3:166-176, 1978
12. Antel JP, Weinrich M, Arnason BGW: Circulating suppressor cells in man as a function of AGE. Clin Immunol Im- munopathol 6:192-198, 1978
13. Olsson JE, Pettersson B: A comparison between agar gel electrophoresis and CSF serum quotients of IgG and albumin on neurological diseases. Acta Neurol Scand 53:308322, 1976
14. Tourtellotte WW: On cerebrospinal fluid IgG quotients in multiple sclerosis and other diseases: A review and a new formula to estimate the amount of IgG synthesized per day by the central nervous system. J Neurol Sei 10:279-304, 1970
15. Johnson KP, Arrigo SC, Nelson BJ, et al: Agarose electrophoresis of cerebrospinal fluid in multiple sclerosis. Neurology (Minneap) 27:273-277, 1977
16. Trotter JL, Brooks BR: Pathogenesis of CSF immunoglobulins. In Woods JH (Editor): Neurobiology of Cerebrospinal Fluid. New York, Plenum Press, 1980
17. Hershey LA, Trotter JL, Banks G: The use and abuse of the cerebrospinal fluid IgG profile. Ann Neurol, 1980 (In press)
18. Johnson KP, Nelson BJ: Multiple sclerosis: Diagnostic usefulness of cerebrospinal fluid. Ann Neurol 2:425-431, 1977
19. Trotter JL, Banks G, Wang P: Isoelectric focusing of gamma globulins in cerebrospinal fluid from patients with multiple sclerosis. Clin Chem 23:2213-2215, 1977
20. Wilson KS, Parker AC: Adrenal suppression after shortterm corticosteroid therapy. Lancet 1:1030, 1979
21. Butler WI, Rossen RD: Effects of corticosteroids on immunity in man. J Clin Invest 52:2629-2640, 1973
22. Tourtellotte WW, Murthy K, Brandes DW, et al: Schemes to eradicate the multiple sclerosis central nervous system immune reaction. Neurology (Minneap) 26:59-61, 1976
23. Eisner W, Tourtellotte WW, Murthy KN, et al: Multiple sclerosis (MS): Effect of dexamethasone on in situ central nervous system (CNS) IgG synthesis. Neurology 28:403404, 1978
24. Fauci AS, Dale DC, Balow JE: Glucocorticosteroid therapy: Mechanisms of action and clinical considerations. Ann Intern Med 84:304-315, 1976