Activities of amidophosphoribosyltransferase (EC 2.4.2.14) and the purine phosphoribosyltransferases (EC 2.4.2.7 and 2.4.2.8), and the phosphoribosylpyrophosphate content of rat central nervous system at different stages of development. Their possible relationship to the neurological dysfunction in the Lesch-Nyhan syndrome

Journal of the Neurological Sciences

Volumn 46, Issue 2, 1980, Pages 221-232

  Allsop, Jennifer ^a   Watts, R W E ^a  

^a MRC Clinical Research Centre   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDOPHOSPHORIBOSYLTRANSFERASE; PHOSPHORIBOSYL PYROPHOSPHATE; PURINE NUCLEOSIDE PHOSPHORYLASE; ADENINE PHOSPHORIBOSYLTRANSFERASE; GLYCOSYLTRANSFERASE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; PENTOSE PHOSPHATE;

CENTRAL NERVOUS SYSTEM; RAT; THEORETICAL STUDY; AGE; ANIMAL; ARTICLE; BRAIN; ENZYMOLOGY; GLIA; HUMAN; LESCH NYHAN SYNDROME; MALE; METABOLISM; NERVE CELL;

ADENINE PHOSPHORIBOSYLTRANSFERASE; AGE FACTORS; AMIDOPHOSPHORIBOSYLTRANSFERASE; ANIMAL; BRAIN; HUMAN; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LESCH-NYHAN SYNDROME; MALE; NEUROGLIA; NEURONS; PENTOSEPHOSPHATES; PENTOSYLTRANSFERASES; PHOSPHORIBOSYL PYROPHOSPHATE; RATS;

EID: 0018908662     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0022-510X(80)90080-5     Document Type: Article

References (30)

1. Developmental changes in purine phosphoribosyltransferases in human and rat tissues
2. Activities of amidophosphoribosyltransferase and purine phosphoribosyltransferases in developing rat brain (Abstract)
3. Hormonal influences on brain development
4. Cyclic nucleotides in central synaptic function
5. Studies on human erythrocyte IMP: pyrophosphate phosphoribosyltransferase
6. Myelination as a vulnerable period in brain development
7. Human erythrocyte AMP: pyrophosphate phosphoribosyltransferase (EC 2.4.2.8)
8. Undernutrition and the developing brain — The relevance of animal models to the human problem
9. Human phosphoribosylpyrophosphate synthetase — Distribution, purification and properties
10. Possible role for cyclic nucleotides and phosphorylated membrane proteins in the postsynaptic actions of neurotransmitters
11. Phosphorylated proteins as physiological effectors
12. Cyclic nucleotides, phosphorylated proteins and the central nervous system
13. Hypoxanthine guanine phosphoribosyltransferase from rat brain — Purification, kinetic properties, development and distribution
14. Feedback inhibition of purine biosynthesis in ascites tumor cells
15. Discussion
16. On the mechanisms of feedback inhibition of purine biosynthesis de novo in Ehrlich ascites tumor cells in vitro
17. Purine and pyrimidine metabolism — Pathways, pitfalls and perturbations
18. Synthesis de novo of purines in slices of rat brain and liver
19. The Lesch-Nyhan syndrome
20. Dependence of bone marrow cells on liver for purine supply
21. Protein measurement with the Folin phenol reagent
22. Use of phytohaemagglutinin-stimulated lymphocytes to study effects of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) deficiency on polynucleotide and protein synthesis in the Lesch-Nyhan syndrome
23. Purine metabolism and cell physiology
24. Observations on the growth in vitro of myeloid progenitor cells and fibroblasts from hemizygotes and heterozygotes for “complete” and “partial” hypoxanthine-guanine phosphoribosyltransferase (HGPRT) deficiency, and their relevance to the pathogenesis of brain damage in the Lesch-Nyhan syndrome
25. Repression and derepression of purine biosynthesis in mammalian hepatoma cells in culture
26. The biological significance of purine salvage
27. Purines — Supply by liver to tissue
28. Inherited disorder of purine metabolism — Correlation between central nervous system dysfunction and biochemical effects
29. Purine ribonucleotide biosynthesis, interconversion and catabolism in mouse brain in vitro
30. Properties of 5-phosphoribosyl-1-pyrophosphate amidotransferase from human lymphoblasts