A toxicological and pharmacological study of ibuprofen guaiacol ester (AF 2259) in the rat

Toxicology and Applied Pharmacology

Volumn 54, Issue 2, 1980, Pages 332-339

  Cioli, V ^a   Putzolu, S ^a   Rossi, V ^a   Corradino, C ^a  

^a Università Politecnica delle Marche ACRAF Gruppo Angelini   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARRAGEENAN; GUAIACOL; IBUPROFEN; METOXIBUTROPATE;

ADVERSE DRUG REACTION; ANIMAL EXPERIMENT; BEHAVIOR; CENTRAL NERVOUS SYSTEM; DRUG COMPARISON; DRUG TOXICITY; EDEMA; FEVER; GASTROINTESTINAL TOXICITY; GASTROINTESTINAL TRACT; INTESTINE ULCER; INTOXICATION; LETHALITY; ORAL DRUG ADMINISTRATION; RAT; SMALL INTESTINE; STOMACH; STOMACH ULCER;

ANIMAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BEHAVIOR, ANIMAL; COMPARATIVE STUDY; EDEMA; FEMALE; FEVER; GASTROINTESTINAL SYSTEM; GUAIACOL; IBUPROFEN; LETHAL DOSE 50; MALE; MICE; RATS;

EID: 0018896755     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/0041-008X(80)90203-3     Document Type: Article

References (7)

1. A study of the serum concentrations of ibuprofen and guaiacol in rats after oral administration of ibuprofen, guaiacol and AF 2259
2. The role of direct tissue contact in the production of gastrointestinal ulcers by anti-inflammatory drugs in rats
3. Evaluation of the potential of gastric ulceration after administration of certain drugs
4. Drug screening and evaluation of new compounds in animals
5. A new device for plethysmoscopic measuring of small objects
6. A simplified method of evaluating dose-effect experiments
7. Carrageenin-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs