Synthesis of Analogues of the Carboxyl Protease Inhibitor Pepstatin. Effect of Structure on Inhibition of Pepsin and Renin

Journal of Medicinal Chemistry

Volumn 23, Issue 1, 1980, Pages 27-33

  Rich, Daniel H ^a   Sun, Eric T O ^a   Ulm, Edgar ^b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG ANALOG; PEPSIN A; PEPSTATIN; PEPSTATIN DERIVATIVE; RADIOISOTOPE; RENIN; RENIN INHIBITOR; TRIPEPTIDE;

4 AMINO 3 HYDROXY 5 PHENYLVALERIC ACID; DRUG ANALYSIS; DRUG COMPARISON; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; PEPTIDE C 14; POLARIMETRY; STRUCTURE ACTIVITY RELATION; THEORETICAL STUDY; THIN LAYER CHROMATOGRAPHY;

AMINO ACIDS; ANIMAL; IN VITRO; KIDNEY; OLIGOPEPTIDES; PEPSIN A; PEPSTATINS; RENIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, U.S. GOV'T, P.H.S.; SWINE;

EID: 0018890715     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00175a006     Document Type: Article

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