Treatment of Crohn's Disease with 6-Mercaptopurine: A Long-Term, Randomized, Double-Blind Study

New England Journal of Medicine

Volumn 302, Issue 18, 1980, Pages 981-987

  Present, Daniel H ^a,b   Korelitz, Burton I ^a   Wisch, Nathaniel ^a   Glass, Joseph L ^a   Sachar, David B ^a   Pasternack, Bernard S ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MERCAPTOPURINE; PLACEBO; PREDNISONE; SALAZOSULFAPYRIDINE;

CLINICAL TRIAL; CONTROLLED STUDY; CROHN DISEASE; DIGESTIVE SYSTEM; DOUBLE BLIND PROCEDURE; DRUG THERAPY; HUMAN; LARGE INTESTINE; MAJOR CLINICAL STUDY; RANDOMIZED CONTROLLED TRIAL; SMALL INTESTINE; THERAPY;

EID: 0018888679     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM198005013021801     Document Type: Article

References (27)

1. Winkelman E.I., Brown C.H. Nitrogen mustard in the treatment of chronic ulcerative colitis and regional enteritis: a preliminary report. Cleve Clin Q. 1965; 32:165-174.
2. Brooke B.N., Javett S.L., Davison O.W. Further experience with azathioprine for Crohn#x0027;s disease. Lancet. 1970; 2:1050-1053.
3. Drucker W.R., Jeejeebhoy K.N. Azathioprine — an adjunct to surgical therapy of granulomatous enteritis. Ann Surg. 1970; 172:618-625.
4. Korelitz B.I., Wisch N. Long term therapy of ulcerative colitis with 6-mercaptopurine: a personal series. Am J Dig Dis. 1972; 17:111-118.
5. Wisch N., Korelitz B.I. Immunosuppressive therapy for ulcerative colitis, ileitis, and granulomatous colitis. Surg Clin North Am. 1972; 52:961-969.
6. Fleiss J.L. Statistical methods for rates and proportion. New York: John Wiley, 1973.
7. Korelitz B.I., Glass J.L., Wisch N. Long-term immunosuppressive therapy of ulcerative colitis: continuation of a personal series. Am J Dig Dis. 1973; 18:317-322.
8. Elion G.B., Hitchings G.H. Handbook of experimental pharmacology. Vol 38. Berlin: Springer-Verlag, 1975: 404-25.
9. Berenbaum M.C. Is azathioprine a better immunosuppressive than 6-mercaptopurine? Clin Exp Immunol. 1971; 8:1-8.
10. Brooke B.N., Hoffmann D.C., Swarbrick E.T. Azathioprine for Crohn#x0027;s disease. Lancet. 1969; 2:612-614.
11. Brown C.H., Achkar E. Azathioprine therapy for inflammatory bowel disease: a preliminary report. Am J Gastroenterol. 1970; 54:363-377.
12. Patterson J.F., Norton R.A., Schwartz R.S. Azathioprine treatment of ulcerative colitis, granulomatous colitis and regional enteritis. Am J Dig Dis. 1971; 16:327-332.
13. Brooke B.N., Cave D.R., King D.W. Place of azathioprine for Crohn#x0027;s disease. Lancet. 1976; 1:1041-1042.
14. Willoughby J.M.T., Kumar P.J., Beckett J., Dawson A.M. Controlled trial of azathioprine in Crohn#x0027;s disease. Lancet. 1971; 2:944-947.
15. Watson W.C., Bukowsky M. Azathioprine in management of Crohn#x0027;s disease: a randomized crossover study. Gastroenterology. 1974; 66:796.
16. Rhodes J., Bainton D., Beck P., Campbell H. Controlled trial of azathioprine in Crohn#x0027;s disease. Lancet. 1971; 2:1273-1276.
17. Klein M., Binder H.J., Mitchell M., Aaronson R., Spiro H. Treatment of Crohn#x0027;s disease with azathioprine: a controlled evaluation. Gastroenterology. 1974; 66:916-922.
18. Rosenberg J.L., Levin B., Wall A.J., Kirsner J.B. A controlled trial of azathioprine in Crohn#x0027;s disease. Am J Dig Dis. 1975; 20:721-726.
19. O#x0027;Donoghue D.P., Dawson A.M., Powell-Tuck J., Brown R.L., Lennard-Jones J.E. Double-blind withdrawal trial of azathioprine as maintenance treatment for Crohn#x0027;s disease. Lancet. 1978; 2:955-957.
20. Sachar D.B., Present D.H. Immunotherapy in inflammatory bowel disease. Med Clin North Am. 1978; 62:173-183.
21. Summers R.W., Switz D.M., Sessions J.T. Jr., et al. National Cooperative Crohn#x0027;s Disease Study: results of drug treatment. Gastroenterology. 1979; 77:847-869.
22. Best W.R., Becktel J.M., Singleton J.W., Kern F. Jr. Development of a Crohn#x0027;s disease activity index: National Cooperative Crohn#x0027;s Disease Study. Gastroenterology. 1976; 70:439-444.
23. Best W.R., Becktel J.M., Singleton J.W. Rederived values of the eight coefficients of the Crohn#x0027;s Disease Activity Index (CDAI). Gastroenterology. 1979; 77:843-846.
24. Nogueira J.R., Freedman M.A. Acute pancreatitis as a complication of Imuran therapy in regional enteritis. Gastroenterology. 1972; 62:1040-1041.
25. Brooke B.N. Foreword. Clin Gastroenterol. 1972; 1:261.
26. Penn I. Malignancies associated with immunosuppressive or cytotoxic therapy. Surgery. 1978; 83:492-502.
27. Kreuger G.R., Heine U.I. Morphogenesis of two immunologically induced mouse lymphomas. Cancer Res. 1972; 32:573-582.