Diaryl Amidine Derivatives as Oncornaviral DNA Polymerase Inhibitors

Journal of Medicinal Chemistry

Volumn 23, Issue 7, 1980, Pages 787-795

  Clercq, E De ^a   Dann, O ^b  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOFURAN DERIVATIVE; BENZOTHIOPHENE DERIVATIVE; DIMINAZENE; DNA POLYMERASE; ETHIDIUM BROMIDE; INDOLE DERIVATIVE; PENTAMIDINE ISETHIONATE; RADIOISOTOPE; STILBAMIDINE ISETIONATE; TILORONE;

4',6 DIIMIDAZOLINO 2 PHENYLTHIANAPHTHENE; 5 AMIDINO 2 (5 AMIDINO 2 BENZOFURANYL)INDOLE; ANIMAL EXPERIMENT; DIARYLAMIDINE DERIVATIVE; DNA SYNTHESIS; DOSE RESPONSE; DRUG ANALYSIS; DRUG COMPARISON; DRUG RESPONSE; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; MOLONEY MURINE SARCOMA ONCOVIRUS; MOUSE; ONCOVIRINAE; PHARMACOKINETICS; STRUCTURE ACTIVITY RELATION; THEORETICAL STUDY; THYMIDINE PHOSPHATE H 3;

AMIDINES; ANIMAL; ANTINEOPLASTIC AGENTS; KINETICS; LEUKEMIA, EXPERIMENTAL; MICE; MOLONEY MURINE LEUKEMIA VIRUS; RETROVIRIDAE; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TILORONE;

EID: 0018878653     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00181a016     Document Type: Article

References (41)

1. Chandra, P.; Ebener, U.; Steel, L. K.; Laube, H.; Gotz, A. “Advances in Cancer Research”: Gallo, R. C., Ed.; CRC Press: Cleveland, Ohio, 1977; pp 167-187.
2. Smith, R. G.; Gallo, R. C. Life Sci. 1974, 15, 1711.
3. Chandra, P.; Steel, L. K.; Ebener, U.; Woltersdorf, M.; Laube, H.; Kornhuber, B.; Mildner, B.; Gotz, A. Pharmacol. Ther., Part A, 1977, 1, 231.
4. De Clercq, E. “Antiviral Mechanisms in the Control of Neoplasia” Chandra, P., Ed.; Plenum Press: New York, 1979; pp 539-551.
5. De Clercq, E.; Fukui, T.; Kakiuchi, N.; Ikehara, M.; Hattori, M.; Pfleiderer, W. Cancer Lett. 1979, 7 27.
6. De Clercq, E. Cancer Lett. 1979, 8 9.
7. Chermann, J.-C.; Sinoussi, F. C.; Jasmin, C. Biochem. Biophys. Res. Commun. 1975, 65 1229.
8. Dann, O.; Bergen, G.; Demant, E.; Volz, G. Justus Liebigs Ann. Chem. 1971, 749 68.
9. Kapuscinski, J.; Szer, W. Nucleic Acids Res. 1979, 6 3519.
10. Kapuscinski, J.; Yanagi, K. Nucleic Acids Res. 1979, 6 3535.
11. Chandra, P.; Mildner, B.; Dann, O.; Metz, A. Mol. Cell. Biochem. 1977, 18 81.
12. Mildner, B.; Metz, A.; Chandra, P. Cancer Lett. 1978, 4 89.
13. Dann, O.; Bergen, G.; Demant, E.; Volz, G. Justus Liebigs Ann. Chem. 1971, 749 68.
14. Dann, O.; Fernbach, R.; Pfeifer, W.; Demant, E.; Bergen, G.; Lang, S.; Lürding, G. Justus Liebigs Ann. Chem. 1972, 760 37.
15. Dann, O.; Hieke, E.; Hahn, H.; Miserre, H. H.; Lürding, G.; Rössler, R. Justus Liebigs Ann. Chem. 1970, 734 23.
16. Dann, O.; Fick, H.; Pietzner, B.; Walkenhorst, E.; Fernbach, R.; Zeh, D. Justus Liebigs Ann. Chem. 1975, 1975 160.
17. Dann, O.; Volz, G.; Demant, E.; Pfeifer, W.; Bergen, G.; Fick, H.; Walkenhorst, E. Justus Liebigs Ann. Chem. 1973, 1973 1112.
18. Tidwell, R. R.; Geratz, J. D.; Dann, O.; Volz, G.; Zeh, D.; Loewe, H. J. Med. Chem. 1978, 21 613.
19. Dann, O.; Volz, G. Justus Liebigs Ann. Chem. 1980, in press.
20. Dann, O.; Ruff, J. Justus Liebigs Ann. Chem. 1980, in press.
21. Dann, O.; Griessmeier, H. Justus Liebigs Ann. Chem. 1980, in press.
22. Wander, A.; British Patent 1007-334, 1965.
23. Chem. Abstr. 1966, 64 5102.
24. Dann, O.; Char, H. Justus Liebigs Ann. Chem. 1980, in press.
25. Dann, O.; Wolff, H. P. Justus Liebigs Ann. Chem. 1980, in press.
26. Chandra, P.; Zunino, F.; Götz, A. FEBS Lett. 1972, 22 161.
27. Chandra, P.; Will, G.; Gericke, D.; Gotz, A. Biochem. Pharmacol. 1974, 23 3259.
28. Schafer, M. P.; Chirigos, M. A.; Papas, T. S. Cancer Chemother. Rep. 1974, 58 821.
29. Green, M.; Rankin, A.; Gerard, G. F.; Grandgenett, D. P.; Green, M. R. J. Natl. Cancer Inst. 1975, 55 433.
30. Chandra, P.; Woltersdorf, M. Biochem. Pharmacol. 1976, 25 877.
31. Baltimore, D.; Smoler, D. Proc. Natl. Acad. Sci. U.S.A. 1971, 68 1507.
32. Goodman, N. C.; Spiegelman, S. Proc. Natl. Acad. Sci. U.S.A. 1971, 68 2203.
33. Fridlender, B.; Fry, M.; Bolden, A.; Weissbach, A. Proc. Natl. Acad. Sci. U.S.A. 1972, 69 452.
34. Robert, M. S.; Smith, R. G.; Gallo, R. C.; Sarin, P. S.; Abrell, J. W. Science 1972, 176 798.
35. Gerard, G. F.; Rottman, F.; Green, M. Biochemistry 1974, 13 1632.
36. Gerard, G. F. Biochem. Biophys. Res. Commun. 1975, 63 706.
37. Mikke, R.; Kielanowska, M.; Shugar, D.; Zmudzka, B. Nucleic Acids Res. 1976, 3 1603.
38. Kotler, M.; Becker, Y. Nature (London), New Biol. 1971, 234 212.
39. Kotler, M.; Becker, Y. FEBS Lett. 1972, 22 222.
40. Chandra, P.; Zunino, F.; Gotz, A.; Wacker, A.; Gericke, D.; Di Marco, A.; Casazza, A. M.; Giuliani, F. FEBS Lett. 1972, 21 154.
41. De Clercq, E.; Claes, P. J. Biochim. Biophys. Acta 1973, 331 328.