Synthesis and Antitumor Activity of 2, 4-Diamino-6-(2, 5-Dimethoxybenzyl)-5-Methylpyrido[2, 3-d]Pyrimidine

Journal of Medicinal Chemistry

Volumn 23, Issue 3, 1980, Pages 327-329

  Grivsky, Eugene M ^a   Lee, Shuliang ^a   Sigel, Carl W ^a   Duch, David S ^a   Nichol, Charles A ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINOPYRIDO[2,3 D]PYRIMIDINE DERIVATIVE; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; METHOTREXATE; METODICLOROFEN; PIRITREXIM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CYTOTOXICITY; DOSE RESPONSE; DRUG ANALYSIS; DRUG COMPARISON; DRUG IDENTIFICATION; DRUG RESPONSE; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKEMIA L 1210; RAT; SARCOMA 180; THEORETICAL STUDY; WALKER CARCINOMA;

EID: 0018874182     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00177a025     Document Type: Article

References (20)

1. B. S. Hurlbert, K. W. Ledig, P. Stenbuck, B. F. Valenti, and G. H. Hitchings, J. Med. Chem., 11, 703 (1968);.
2. B. S. Hurlbert and B. F. Valenti, J. Med. Chem., 11, 708 (1968).
3. B. S. Hurlbert, R. Ferone, T. A. Herrmann, G. H. Hitchings, M. Barnett, and S. R. M. Bushby, J. Med. Chem., 11, 711 (1968).
4. J. C. Cavallito, C. A. Nichol, W. D. Brenckman, Jr., R. L. DeAngelis, D. R. Stickney, W. S. Simmons, and C. W. Sigel, Drug Metab. Dispos., 6, 329 (1978).
5. M. L. Murphy, R. R. Ellison, D. A. Karnofsky, and J. H. Burchenal, J. Clin. Invest., 33, 1388 (1954).
6. D. R. Stickney, W. S. Simmons, R. L. DeAngelis, R. W. Rundles, and C. A. Nichol, Proc. Am. Assoc. Cancer Res., 14, 52(1973).
7. L. A. Price, J. H. Goldie, and B. T. Hill, Br. Med. J., 2, 230 (1975).
8. L. A. Price and B. T. Hill, Proc. Am. Assoc. Cancer Res., 17, 15 (1976).
9. D. S. Miller, R. W. Rundles, C. A. Nichol, J. L. Woolley, and C. W. Sigel, Proc. Am. Soc. Clin. Oncol., 17, 263 (1976).
10. P. Alberto, R. Peytremann, R. Medenica, and M. Beretta-Piccoli, Cancer Chemother. Pharmacol., 1, 101 (1978).
11. R. T. Skeel, A. R. Cashmore, W. L. Sawicki, and J. R. Bertino, Cancer Res., 36, 48 (1976).
12. D. S. Duch, S. W. Bowers, and C. A. Nichol, Biochem. Pharmacol., 27, 1507 (1978).
13. W. T. Irwin and D. G. Wibberley, Adv. Heterocycl. Chem., 10, 150-171 (1969).
14. A. Vilsmeier and A. Haack, Ber. Dtsch. Chem. Ges. B, 60, 119 (1927);.
15. H. H. Bosshard, R. Mory, M. Schmid, and H. Zollinger, Helv. Chim. Acta, 42, 1653 (1959).
16. E. M. Grivsky and S. Lee, unpublished results.
17. D. S. Duch, C. W. Sigel, S. W. Bowers, M. P. Edelstein, J. C. Cavallito, R. G. Foss, and C. A. Nichol, Proceedings of the 11th International Congress of Chemotherapy, Boston, Oct 1979, in press.
18. D. S. Duch, D. D. Bigner, S. W. Bowers, and C. A. Nichol, Cancer Res., 39, 487 (1979).
19. D. S. Duch, M. P. Edelstein, and C. A. Nichol, Pharmacologist, 21, 266 (1979).
20. A. Leo, C. Hansch, and D. Elkins, Chem. Res., 71, 525 (1971).