Persistence of resistant putative preneoplastic hepatocytes induced by n-nitrosodiethylamine or n-methyl-n-nitrosourea

Cancer Research

Volumn 40, Issue 4, 1980, Pages 1112-1118

  Solt, Dennis B ^a   Cayama, Edmundo ^b   Sarma, D S R ^b   Farber, Emmanuel ^b  

^a HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DIETHYLNITROSAMINE; METHYLNITROSOUREA; N (2 FLUORENYL)ACETAMIDE;

ANIMAL EXPERIMENT; CELL PROLIFERATION; CELL TRANSFORMATION; CHEMICAL CARCINOGENESIS; DRUG RESISTANCE; IN VITRO STUDY; LIVER; LIVER CANCER; LIVER CARCINOGENESIS; LIVER CELL; LIVER RESECTION; RAT;

2-ACETYLAMINOFLUORENE; ANIMAL; CELL DIVISION; COMPARATIVE STUDY; DIETHYLNITROSAMINE; DRUG RESISTANCE; HEPATECTOMY; LIVER NEOPLASMS, EXPERIMENTAL; MALE; METHYLNITROSOUREA; NITROSAMINES; NITROSOUREA COMPOUNDS; PRECANCEROUS CONDITIONS; RATS; RATS, INBRED F344; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS;

EID: 0018841280     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Berenblum, I. Sequential aspects of chemical carcinogenesis in skin. In: F.F. Becker (ed.), Cancer: A Comprehensive Treatise, Vol. 1, pp. 323–344. New York: Plenum Press, 1975.
2. Berenblum, I., and Shubik, P. The persistence of latent tumour cells induced by a single application of 9:10 dimethyl-1,2-benzanthracene. Br. J. Cancer, 3: 384–386, 1949.
3. Burns, F.J., Albert, R.E., and Pereira, M.A. Initiation of mouse skin tumors during prolonged exposure to benzo(a) pyrene. Proc. Am. Assoc. Cancer Res., 18: 212, 1977.
4. Cayama, E., Tsuda, H., Sarma, D.S.R., and Farber, E. Initiation of chemical carcinogenesis requires cell proliferation. Nature (Lond.), 275. 60–62, 1978.
5. Cote, J., Oehlert, W., and Buchner, F. Autoradiographic studies on malignant degeneration of the epidermal cells of the skin of mice after application of methylcholanthrene. Beitr. Pathol. Anat. Allg., Pathol. 125: 280–303, 1961.
6. Craddock, V. Induction of liver tumours in rats by a single treatment with nitroso compounds given after partial hepatectomy. Nature (Lond.) 245: 386–388, 1973.
7. Craddock, V.M. Cell proliferation and experimental liver cancer. In: H.M. Cameron, D.A. Linsell, and G.P. Warwick (eds.), Liver Cell Cancer, pp. 153–201. Amsterdam: Elsevier, 1976.
8. Craddock, V.M., and Frei, J.V. Induction of liver adenomata in the rat by a single treatment with N-methyl-N-nitrosourea given at various times after partial hepatectomy. Br. J. Cancer, 30: 503–511, 1974.
9. Farber, E. Hyperplastic liver nodules. Methods Cancer Res., 7: 345–375, 1973.
10. Farber, E. Response of liver to carcinogens: a new analytical approach. In: E. Farber and M.M. Fisher (eds.), Toxic Liver Injury, pp. 445–467. New York: Marcel Dekker, 1979.
11. Farber, E. The sequential analysis of liver cancer development. Biochim. Biophys. Acta, in press, 1980.
12. Farber, E., and Cameron, R.G. The sequential analysis of cancer development. Adv. Cancer Res., 31: 125–226, 1980.
13. Farber, E., Parker, S., and Gruenstein, M. The resistance of putative premalignant liver cell populations, hyperplastic nodules, to the acute cytotoxic effects of some hepatocarcinogens. Cancer Res., 36: 3879–3887, 1976.
14. Farber, E., and Solt, D. A new liver model for the study of promotion. In: T.J. Slaga, A. Sivak, and R.K. Boutwell (eds.), Carcinogenesis, Vol. 2, pp. 443–448. New York: Raven Press, 1978.
15. Hecker, E. Phorbol esters from croton oil. Chemical nature and biological activities. Naturwissenschaften, 54: 282–284, 1967.
16. Herbst, A.L., Ulfelder, H., and Poskanzer, D.C. Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women. N. Engl. J. Med., 284: 878–881, 1971.
17. Hicks, R.M., and Chowaniec, J. Experimental induction, histology and ultrastructure of hyperplasia and neoplasia of the urinary bladder epithelium. Int. Rev. Exp. Pathol., 18: 199–280, 1978.
18. Kaufman, D.G., Kaufmann, W.K., Rice, J.M., and Wenk, M.L. Cell cycle variation in susceptibility to hepatocarcinogenesis by MNU. Proc. Am. Assoc. Cancer Res., 19: 183, 1978.
19. Laerum, O.D., and Rajewsky, M.F. Neoplastic transformation of fetal rat brain cells in culture after exposure to ethylnitrosourea in vivo. J. Natl. Cancer Inst., 55: 1171–1188, 1975.
20. Lijinsky, W. Interaction with nucleic acids of carcinogenic and mutagenic N-nitroso compounds. Prog. Nucleic Acid Res. Mol. Biol., 17: 247–269. 1976.
21. Mottram, J.C. A developing factor in experimental blastogenesis. J. Pathol. Bacteriol., 56:181–187, 1944.
22. Mottram, J.C. A diurnal variation in the production of tumors. J. Pathol. Bacteriol., 57: 265–267, 1945.
23. Ogawa, K., Medline, A., and Farber, E. Sequential analysis of hepatic carcinogenesis: a comparative study of the ultrastructure of preneoplastic malignant, prenatal, postnatal and regenerating liver. Lab Invest., 40: 22–35, 1979.
24. Peraino, C., Fry, R.J.M., and Grube, D.D. Drug-induced enhancement of hepatic tumorigenesis. In: T.J. Slaga, A. Sivak, and R.K. Boutwell (eds.) Carcinogenesis, Vol. 2, pp. 421–432. New York: Raven Press, 1978.
25. Peraino, C., Fry, R.J.M., Staffeldt, E., and Kisielski, W.E. Effects of varying the exposure to phenobarbital on its enhancement of 2-acetyl-aminoflu-orene-induced hepatic tumorigenesis in the rat. Cancer Res., 33: 2701–2705, 1973.
26. Pitot, H.C., Barsness, L., Goldworthy, T., and Kitagawa, T. Biochemical characterization of stages of hepatocarcinogenesis after a single dose of diethylnitrosamine. Nature (Lond.), 271: 456–458, 1978.
27. Pitot, H.C., Barsness, L., and Kitagawa, T. Stages in the process of hepatocarcinogenesis in rat liver. In: T.J. Slaga, A. Sivak, and R.K. Boutwell (eds.), Carcinogenesis, Vol. 2, pp. 433–442. New York: Raven Press, 1978.
28. Pound, A.W. Carcinogenesis and cell proliferation. N.Z. Med. J., 2: 77–84, 1967.
29. Rabes, H., Hartenstein, R., and Scholze, P. Hemmung der Proliferation-saktivitat partiell resezierter Leber durch Diathylnitrosamin. Z. Krebsforsch., 73: 239–241, 1970.
30. Rous, P., and Kidd, J.G. Conditional neoplasms and subthreshold neoplastic states. J. Exp. Med., 73: 299–390, 1941.
31. Rubin, E., Masuko, K., Goldfarb, S., and Zak, F.G. Role of cell proliferation in hepatic carcinogenesis. Proc. Soc. Exp. Biol. Med., 115: 381–384,1964.
32. Scherer, E., and Emmelot, P. Foci of altered liver cells induced by a single dose of diethylnitrosamine and partial hepatectomy: their contribution to hepatocarcinogenesis in the rat. Eur. J. Cancer, 11: 145–154, 1975.
33. Scherer, E., Hoffmann, M., Emmelot, P., and Friedrich-Freksa, H. Quantitative study on foci of altered liver cells induced in the rat by a single dose of diethylnitrosamine and partial hepatectomy. J. Natl. Cancer Inst., 49: 93–106, 1972.
34. Shinozuka, H., and Ritchie, A.C. Pretreatment with croton oil, DNA synthesis and carcinogenesis followed by croton oil. Int. J. Cancer, 2: 77–84, 1967.
35. Sivak, A. Cocarcinogenesis. Biochim. Biophys. Acta. 560: 67–89, 1979.
36. Slaga, T.J., Sivak, A., and Boutwell. R.K. (eds.). Carcinogenesis, Vol. 2. Mechanisms of Tumor Promotion and Cocarcinogenesis. New York: Raven Press, 1978.
37. Solt, D., and Farber, E. New principle for the analysis of chemical carcinogenesis. Nature (Lond.), 263: 701–743, 1976.
38. Solt, D.B., and Farber, E. Persistence of carcinogen-induced initiated hepatocytes in liver carcinogenesis. Proc. Am. Assoc. Cancer Res., 16: 52, 1977.
39. Solt, D.B., Medline, A., and Farber, E. Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis. Am. J. Pathol., 88: 595–618, 1977.
40. Tsuda, H., and Farber, E. Initiation of putative preneoplastic liver lesions by single doses of non-liver and liver carcinogens plus partial hepatectomy (PH). Proc. Am. Assoc. Cancer Res., 20: 15, 1979.
41. Ying, T.S., and Sarma, D.S.R. Role of cell necrosis in the induction of preneoplastic lesions. Proc. Am. Assoc. Cancer Res., 20: 14, 1979.