Experimental measurements and empirical modelling of the regional deposition of inhaled particles in humans

American Industrial Hygiene Association Journal

Volumn 41, Issue 6, 1980, Pages 399-409

  Chan, Tai L ^a   Lippmann, Morton ^b  

^a GM Research Lab   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FERRIC OXIDE; GOLD 198; RADIOISOTOPE; TECHNETIUM 99M;

AEROSOL; BRONCHUS; DUST; HUMAN CELL; IN VITRO STUDY; INHALATIONAL DRUG ADMINISTRATION; NORMAL HUMAN; PARTICULATE MATTER; RESPIRATORY SYSTEM;

AEROSOLS; BRONCHI; HEAD; HUMAN; LUNG; MODELS, ANATOMIC; MODELS, BIOLOGICAL; PARTICLE SIZE; PULMONARY ALVEOLI; RESPIRATORY SYSTEM; SUPPORT, U.S. GOV'T, P.H.S.; TRACHEA;

EID: 0018823886     PISSN: 00028894     EISSN: None     Source Type: Journal    
DOI: 10.1080/15298668091424942     Document Type: Article

References (59)

1. Stuart, B.O.: Deposition of Inhaled Aerosols. Arch. Int. Med. 131: 60–73 (1973).
2. Davies, C.N.: Deposition of Inhaled Particles in Man. Chem. Ind. pp. 441–444 (June 1, 1974).
3. Morrow, P.E.: Theoretical and Experimental Models for Dust Deposition and Retention in Man. Rev. Environ. Health 1: 186–212 (1974).
4. Mercer, T.T.: The Deposition Model of the Task Group on Lung Dynamics: A Comparison with Recent Experimental Data. Health Phys. 29: 673–680 (1975).
5. Yeh, H.C., R.F. Phalen and O.G. Raabe: Factors Influencing the Deposition of Inhaled Particles. Environ. Health Perspect. 15: 147–156 (1976).
6. Lippmann, M.: Regional Deposition of Particles in the Human Respiratory Tract. In: Handbook of Physiology - Reaction to Environmental Agents (D.H.K. Lee, et al. Ed.) pp. 213–232. The American Physiological Society, Bethesda, Md. (1977).
7. Heyder, J., L. Armbruster, J. Gebhart, E. Grein and W. Stahlhofen: Total Deposition of Aerosol Particles in the Human Respiratory Tract for Nose and Mouth Breathing. J. Aerosol Sci. 6: 311–328 (1975).
8. Camner, P., K. Philipson and L. Friberg: Tracheobronchial Clearance in Smoking: Discordant Twins. Arch. Environ. Health 24: 82–87 (1972).
9. Bohning, D.E., R.E. Albert, M. Lippmann and W.M. Foster: Tracheobronchial Particle Deposition and Clearance. Arch. Environ. Health 30: 457–462 (1975).
10. Heyder, J., J. Gebhart, C. Roth, W. Stahlhofen, B. Stuck, G. Tarroni, T. De Zaiacomo, M. Formignani, C. Melandri and V. Prodi: lntercomparison of Lung Deposition Data for Aerosol Particles. J. Aerosol Sci. 9: 147–155 (1978).
11. Cheng, Y.S.: Particle Deposition in Bends and Repeatedly Bifurcating Tubes. Ph.D. Thesis, Syracuse University, Syracuse, New York (1976).
12. Davis, J.D.: Anatomic Variations of the Normal Tracheobronchial Tree. Acta. Otol. 9: 404–413 (1929).
13. Jesseph, J.E. and K.A. Merendino: Dimensional Interrelationship of the Major Components of the Tracheobronchial Tree. Surg. Gynecol. Obstet. 105: 210–214 (1957).
14. Chamberlain, A.C. and E.D. Dyson: The Dose to the Trachea and Bronchi from the Decay Products of Radon and Thoron. Br. J. Radiol. 29: 317–325 (1956).
15. Martin, D. and W. Jacobi: Diffusion Deposition of Small-sized Particles in the Bronchial Tree. Health Phys. 23: 23–29 (1972).
16. Schlesinger, R.B. and M. Lippmann. Particle Deposition in Casts of the Human Upper Tracheobronchial Tree. Am. Ind. Hyg. Assoc. J. 33: 237–251 (1972).
17. Bell, K.A.: Aerosol Deposition in Models of a Human Lung Bifurcation. Ph.D. Thesis, California Institute of Technology, Pasadena, California (1974).
18. Johnston, J.R., K.D. Isles and D.C.F. Muir: Inertial Deposition of Particles in Human Branching Airways. Inhaled Particles IV. (Edited by W.H. Walton), pp. 61–72. Pergamon Press, New York & Oxford (1977).
19. Ferron, G.A.: The Size of Soluble Aerosol Particles as a Fraction of the Humidity of the Air-Application to the Human Respiratory Tract. J. Aerosol Sci. 8: 429–445 (1977).
20. Lee, W. and C.S. Wang: Particle Deposition in Systems of Repeatedly Bifurcating Tubes. Inhaled Particles IV. (Edited by W.H. Walton), pp. 49–59. Pergamon Press, Oxford and New York (1977).
21. Schlesinger, R.B., D.E. Bohning, T.L. Chan and M. Lippmann: Particle Deposition in a Hollow cast of the Human Tracheobronchial Tree. J. Aerosol Sci. 8: 429–445 (1977).
22. Chan, T.L., M. Lippmann, V. Cohen and R.B. Schlesinger: Effect of Electrostatic Charges on Particle Deposition in a Hollow Cast of the Human Larynx-Tracheobronchial Tree. J. Aerosol Sci. 9: 463–468 (1978).
23. Yang, Y., W. Lee and C. Wang: Deposition of Half Micron Particles from Steady Flows in Models of Human Bronchial Airways. AICHE Symposium Series #147:71: 33–37 (1975).
24. Shaw, D.T. and N. Rajendran: Diffusional Deposition of Airborne Particles in Curved Bronchial Airways. J. Aerosol Sci. 8: 191–198 (1977).
25. Gormley, P.G. and M. Kennedy: Diffusion from a Stream Flowing Through a Cylindrical Tube. Proc. Royal Irish Acad. 52A: 163–169 (1949).
26. Landahl, H.D.: Particle Removal by the Respiratory System. Bull. Math. Biophys. 25: 29–39 (1963).
27. Taulbee, D.B. and C.P. Yu: A Theory of Aerosol Deposition in the Human Respiratory Tract. J. Appl. Physiol. 33: 77–85 (1975).
28. Giacomelli-Maltoni, G., C. Melandri, V. Prodi and G. Tarroni: Deposition Efficiency of Monodispersed Particles in Human Respiratory Tract. Am. Ind. Hyg. Assoc. J. 33: 603–610 (1972).
29. Foord, N., A. Black and M. Walsh: Regional Deposition of 2.5–7.5 Micrometer Diameter Inhaled Particles in Healthy Male Nonsmokers. J. Aerosol Sci. 9: 343–357 (1978).
30. Swift, D.L., F. Shanty and J.T. O'Neil: Human Respiratory Deposition Patterns of Fume-like Particles. Presented in part at the American Industrial Hygiene Conference in New Orleans, Louisiana (May 26, 1977).
31. Task Group on Lung Dynamics: Deposition and Retention Models for Internal Dosimetry of the Human Respiratory Tract. Health Phys. 12: 173–207 (1966).
32. Albert, R.E., M. Lippmann, H. Peterson, J. Berger, K. Sanborn and D. Bohning: Bronchial Deposition and Clearance of Aerosols. Arch. Int. Med.131.115–127(1973).
33. Spertell, R.B. and M. Lippmann: Airborne Density of Ferric Oxide Aggregate Microspheres. Am. Ind. Hyg. Assoc. J. 32: 734–739 (1971).
34. Moss, O.R., H.J. Ettinger and J.R. Coulter: Aerosol Density Measurements Using a Modified Spiral Centrifuge Aerosol Spectrometer. Env. Sci. Tech. 6: 614–617 (1972).
35. Albert, R.E., M. Lippmann, J.R. Spiegelman, C. Strehlow, W. Briscoe, P. Wolfson and N. Nelson: The Clearance of Radioactive Particles from the Human Lung. Inhaled Particles and Vapours II (Edited by C.N. Davies) pp. 351–359, Pergamon Press, Oxford (1966).
36. 2 Exposure on Bronchial Clearance in the Donkey. Arch. Env. Health 17: 321–326 (1968).
37. Stöber, W. and Flachsbart: Size-separating Precipitation in a Spinning Spiral Duct. Env. Sci. Tech.3: 1280–1296(1969).
38. Liu, B.Y.H. and D.Y.H. Pui: Electrical Neutralization of Aerosol. J. Aerosol Sci. 5: 465–472 (1974).
39. Bennett, I.: New York University Medical Center Policy on the Protection of Human Subjects. (July 1,1974).
40. Lippmann, M. and R.E. Albert: The Effect of Particle Size on the Regional Deposition of Inhaled Aerosols in the Human Respiratory Tract. Am. Ind. Hyg. Assoc. J. 30: 357–375 (1969).
41. Knight, V., R.B. Couch and H.D. Landahl: Effect of Lack of Gravity on Airborne Infection During Space Flight. J. Am. Med. Assoc. 214: 513–518 (1970).
42. Yu, C.P.: A Two-component Theory of Aerosol Deposition in Lung Airways. Bull. Math. Biol. 40: 693–706 (1978).
43. Hoffmann, R.A. and J. Billingham: Effect of Altered G Levels on Deposition of Particulates in the Human Respiratory System. J. Appl. Physiol. 38: 955–958 (1975).
44. Yu, C.P.: Personal Communication (1979).
45. Cheng, Y.S. and C.S. Wang: Inertial Deposition of Particles in a Bend. J. Aerosol Sci. 6: 139–146 (1975).
46. Davies, C.N., M.J. Lever and S.J. Rothenberg: Experimental Studies of Deposition of Particles in the Human Lung. Inhaled Particles IV. (Edited by W.H. Walton) pp. 151–160. Pergamon Press, Oxford (1977).
47. Stahlhofen, W., J. Gebhart and J. Heyder: Experimental Determination of Regional Deposition of Aerosol Particles in the Human Respiratory Tract. Am. Ind. Hyg. Assoc. J. 41: 385–398 (1980).
48. Lippmann, M.: Deposition and Clearance of Inhaled Particles in the Human Nose. Ann. Otol. Rhinol. Laryngol. 79: 519–528 (1970).
49. Heyder, J. and G. Rudolf: Deposition of Aerosol Particles in the Human Nose. Inhaled Particles IV (Edited by W.H. Walton), pp. 107–125. Pergamon Press, Oxford (1977).
50. Albert, R.E. and L.C. Arnett: Clearance of Radioactive Dust from the Lung. Arch. Ind. Health 12: 99–106 (1955).
51. Lippmann, M. and B. Altshuler: Regional Deposition of Aerosols. Air Pollution and the Lung (Edited by E.F. Aharonson, A. Ben-David, and M.A. Klingberg) pp. 25–48. Halsted Press-Wiley, New York (1976).
52. Lourenco, R.V., M.F. Klimek and C.J. Borowski: Deposition and Clearance of 2 Micrometer Particles in the Tracheobronchial Tree of Normal Subjects. J. Clin. Invest. 50: 1411–1420 (1971).
53. Pavia, D. and M.J. Thomson: The Fractional Deposition of Inhaled 2 and 5 Micrometer Particles in the Alveolar and Tracheobronchial Regions of the Healthy Human Lung. Ann. Occup. Hyg. 19: 109–114(1976).
54. Palmes, E.D. and M. Lippmann: Influence of Respiratory Airspaces Dimensions on Aerosol Deposition. Inhaled Particles IV. (Edited by W.H. Walton), pp. 127–135. Pergamon Press, Oxford (1977).
55. Landahl, H.D.: On the Removal of Airborne Droplets by the Human Respiratory Tract. I. The Lung. Bull. Math. Biophys. 12: 43–56 (1950).
56. Cohen, V.R.: Effect of Glyceryl Guiacolate on the Bronchial Clearance of Patients with Chronic Bronchitis. M.S.Thesis, New York University, New York (1977).
57. Fletcher, C. and R. Peto: The Natural History of Chronic Airflow Obstruction. Br. Med. J.1: 1645–1648 (1977).
58. Davies, D.: Disability and Coal Worker's Pneumoconiosis. Br. Med. J. 2: 652–655 (1974).
59. Muir, D.C.F., J. Burns, M. Jacobsen and W. Walton: Pneumoconiosis and Chronic Bronchitis. Br. Med. J. 2: 424–427 (1977).