Studies on the destruction of adrenal and testicular cytochrome P-450 by spironolactone. Requirement for the 7alpha-thio group and evidence for the loss of the heme and apoproteins of cytochrome P-450.

Journal of Biological Chemistry

Volumn 254, Issue 5, 1979, Pages 1726-1733

  Menard, R H ^a   Guenthner, T M ^a   Kon, H ^a   Gillette, J R ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

APOENZYME; CYTOCHROME P 450 ENZYME SYSTEM; CYTOCHROME P450; DRUG DERIVATIVE; HEME; SPIRONOLACTONE;

ADRENAL GLAND; ANIMAL; ARTICLE; COMPARATIVE STUDY; DOG; DRUG EFFECT; ENZYMOLOGY; GUINEA PIG; MALE; METABOLISM; MICROSOME; RAT; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION; TESTIS;

ADRENAL GLANDS; ANIMAL; APOENZYMES; COMPARATIVE STUDY; CYTOCHROME P-450 ENZYME SYSTEM; DOGS; GUINEA PIGS; HEME; MALE; MICROSOMES; RATS; SPECIES SPECIFICITY; SPIRONOLACTONE; STRUCTURE-ACTIVITY RELATIONSHIP; TESTIS;

EID: 0018786263     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (0)