Increased Insulin Binding to Erythrocytes in Anorexia Nervosa: Restoration to Normal with Refeeding

New England Journal of Medicine

Volumn 300, Issue 16, 1979, Pages 882-887

  Wachslicht Rodbard, Helena ^a   Gross, Howard A ^a   Rodbard, David ^a   Ebert, Michael H ^a   Roth, Jesse ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HORMONE RECEPTOR; INSULIN I 125; RADIOISOTOPE;

ANOREXIA NERVOSA; BLOOD AND HEMOPOIETIC SYSTEM; DIAGNOSIS; ERYTHROCYTE; HORMONE BINDING; MAJOR CLINICAL STUDY; NORMAL HUMAN;

EID: 0018774424     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM197904193001603     Document Type: Article

References (28)

1. Morton R: Phthsiologia: Or, a treatise of consumptions. London, Printed for Sam Smith and Benj Walford at the Prince's Arms of St. Paul's Churchyard, 1694, p 4
2. Mecklenburg RS, Loriaux DL, Thompson RH, et al: Hypothalamic dysfunction in patients with anorexia nervosa. Medicine (Baltimore) 53: 147–159, 1974
3. Landon J, Greenwood FC, Stamp TCB, et al: The plasma sugar, free fatty acid, cortisol, and growth hormone response to insulin, and the comparison of this procedure with other tests of pituitary and adrenal function. II. In patients with hypothalamic or pituitary dysfunction or anorexia nervosa. J Clin Invest 45: 437–449, 1966
4. Bartels ED: Studies on hypometabolism. I. Anorexia nervosa. Acta Med Scand 124: 185–211, 1946
5. Crisp AH: Some aspects of the evolution, presentation and follow-up of anorexia nervosa. Proc R Soc Med 58: 814–820, 1965
6. Kanis JA, Brown P, Fitzpatrick K, et al: Anorexia nervosa: a clinical, psychiatric, and laboratory study. I. Clinical and laboratory investigation. Q J Med 43: 321–338, 1974
7. Devlin JG: Obesity and anorexia nervosa: a study of growth hormone release. J Ir Med Assoc 68: 227–231, 1975
8. Feighner JP, Robins E, Guze SB, et al: Diagnostic criteria for use in psychiatric research. Arch Gen Psychiatry 26: 57–63, 1972
9. Gambhir KK, Archer JA, Carter L: Insulin radioreceptor assay for human erythrocytes. Clin Chem 23: 1590–1595, 1977
10. Gambhir KK, Archer JA, Bradley CJ: Characteristics of human erythrocyte insulin receptors. Diabetes 27: 701–708, 1978
11. Böyum A: Separation of leukocytes from blood and bone marrow. IV. Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Invest 21: Suppl 97: 77–89, 1968
12. Cline MJ, Lehrer RI: Phagocytosis by human monocytes. Blood 32: 423–435, 1968
13. Scatchard G: The attraction of proteins for small molecules and ions. Ann NY Acad Sci 51: 660–672, 1949
14. De Meyts P, Roth J: Cooperativity in ligand binding: a new graphic analysis. Biochem Biophys Res Commun 66: 1118–1126, 1975
15. Pollet RJ, Standaert ML, Haase BR: Insulin binding to the human lymphocyte receptor: evaluation of the negative cooperativity model. J Biol Chem 252: 5828–5834, 1977
16. De Meyts P, Michiels-Place M: The negative cooperativity of the insulin receptor: binding properties of a non-cooperative insulin analogue, desalanine-desasparagine insulin. Diabetologia 14: 227, 1978
17. Sizonenko PC, Rabinovitch A, Schneider P, et al: Plasma growth hormone, insulin, and glucagon responses to arginine infusion in children and adolescents with idiopathic short stature, isolated growth hormone deficiency, panhypopituitarism and anorexia nervosa. Pediatr Res 9: 733–738, 1975
18. Archer JA, Gorden P, Roth J: Defect in insulin binding to receptors in obese man: amelioration with caloric restriction. J Clin Invest 55: 166–174, 1975
19. Olefsky JM: Decreased insulin binding to adipocytes and circulating monocytes from obese subjects. J Clin Invest 57: 1165–1172, 1976
20. Goldfine ID, Kahn CR, Neville DM Jr, et al: Decreased binding of insulin to its receptors in rats with hormone induced insulin resistance. Biochem Biophys Res Commun 53: 852–857, 1973
21. Olefsky JM, Johnson J, Liu F, et al: The effects of acute and chronic dexamethasone administration on insulin binding to isolated rat hepatocytes and adipocytes. Metabolism 24: 517–527, 1975
22. Kahn CR, Goldfine ID, Neville DM Jr, et al: Alterations in insulin binding induced by changes in vivo in the levels of glucocorticoids and growth hormone. Endocrinology 103: 1054–1066, 1978
23. Soman V, Tamborlane W, DeFronzo R, et al: Fluctuations in insulin binding in isolated growth hormone deficiency (IGHD): mechanism of altered insulin sensitivity. Clin Res 26: 312A, 1978
24. Ip C, Tepperman HM, Holohan P, et al: Insulin binding and insulin response of adipocytes from rats adapted to fat feeding. J Lipid Res 17: 588–599, 1976
25. Olefsky JM, Saekow M: The effects of dietary carbohydrate content on insulin binding and glucose metabolism by isolated rat adipocytes. Endocrinology 103: 2252–2263, 1978
26. Frankel RJ, Jenkins JS: Hypothalamic-pituitary function in anorexia nervosa. Acta Endocrinol 78: 209–221, 1975
27. Hurd HP II, Palumbo PJ, Gharib H: Hypothalamic-endocrine dysfunction in anorexia nervosa. Mayo Clin Proc 52: 711–716, 1977
28. Aro A, Lamberg B-A, Pelkonen R: Hypothalamic endocrine dysfunction in anorexia nervosa. Acta Endocrinol 85: 673–683, 1977