Methotrexate, a High-Affinity Pseudosubstrate of Dihydrofolate Reductase

Biochemistry

Volumn 18, Issue 12, 1979, Pages 2567-2573

  Williams, Jeffrey W ^a   Morrison, John F ^b   Duggleby, Ronald G ^b  

^a AMERICAN CANCER SOCIETY   (United States)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; METHOTREXATE;

ANIMAL EXPERIMENT; ARTICLE; CANCER CHEMOTHERAPY; DRUG ANALYSIS; ENTEROCOCCUS FAECALIS; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; FLUORESCENCE; PRELIMINARY COMMUNICATION;

EID: 0018759051     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi00579a021     Document Type: Article

References (27)

1. Blakley, R. L. (1957) Biochem. J. 65, 331.
2. Blakley, R. L. (1960) Nature (London) 188, 231.
3. Blakely, R. L. (1969) The Biochemistry of Folic Acid and Related Pteridines, North-Holland Publishing Co., Amsterdam.
4. Blakley, R. L., Schrock, M., Sommer, K., &Nixon, P. F. (1971) Ann. N.Y. Acad. Sci. 186, 119.
5. Burchall, J. J., &Chan, M. (1969) Fed. Proc., Fed. Am. Soc. Exp. Biol. 28, 352.
6. Cha, S. (1975) Biochem. Pharmacol. 24, 2177, but see correction by Cha (1976) Biochem. Pharmacol. 25, 1561.
7. Cha, S. (1976) Biochem. Pharmacol. 25, 2695.
8. Chandler, J. P., Hill, D. E., &Spivey, H. O. (1972) Comput. Biomed. Res. 5, 515.
9. D'Souza, L., &Freisheim, J. H. (1972) Biochemistry 11, 3770.
10. Duggleby, R. G., &Morrison, J. F. (1977) Biochim. Biophys. Acta 481, 297.
11. Erickson, J. S., &Mathews, C. K. (1972) J. Biol. Chem. 247, 5661.
12. Freisheim, J. H., &D'Souza, L. (1971) Fed. Proc., Fed. Am. Soc. Exp. Biol. 30, 1201.
13. Frieden, C. (1970) J. Biol. Chem. 245, 5788.
14. Hillcoat, B. L., Nixon, P. F., &Blakley, R. L. (1967) Anal. Biochem. 21, 178.
15. Hitchings, G. H., &Burchall, J. J. (1965) Adv. Enzymol. 27, 417.
16. Hood, K., &Roberts, G. C. K. (1977) Biochem. Soc. Trans. 5, 771.
17. Jackson, R. C., Niethammer, D., &Hart, L. I. (1977) Arch. Biochem. Biophys. 182, 646.
18. McCullough, J. L., Nixon, P. F., &Bertino, J. R. (1971) Ann. N.Y. Acad. Sci. 186, 131.
19. Morrison, J. F. (1969) Biochim. Biophys. Acta 185, 269.
20. Nixon, P. F., &Blakley, R. L. (1968) J. Biol. Chem. 243, 4722.
21. Poe, M., Greenfield, N. J., Hirshfield, J. M., Williams, M. N., &Hoogsteen, K. (1972) Biochemistry 11, 1023.
22. Seeger, D. R., Cosulich, D. B., Smith, J. M., &Hultquist, M. E. (1949) J. Am. Chem. Soc. 71, 1753.
23. Subramanian, S., &Kaufman, B. T. (1978) Proc. Natl. Acad. Sci. U.S.A. 75, 3201.
24. Swann, W. H. (1969) FEBS Lett. Suppl. 2, S39.
25. Williams, J. W., &Morrison, J. F. (1979) Methods Enzymol. (in press).
26. Williams, M. N., Greenfield, N. J., &Hoogsteen, K. (1973a) J. Biol. Chem. 248, 6380.
27. Williams, M. N., Poe, M., Greenfield, N. J., Hirshfield, J. M., &Hoogsteen, K. (1973b) J. Biol. Chem. 248, 6375.