2-Acetylpyridine Thiosemicarbazones. 1. A New Class of Potential Antimalarial Agents

Journal of Medicinal Chemistry

Volumn 22, Issue 7, 1979, Pages 855-862

  Klayman, Daniel L ^a   Bartosevich, Joseph F ^a   Griffin, T Scott ^a   Mason, Carl J ^a   Scovill, John P ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ACETYLPYRIDINE THIOSEMICARBAZONE DERIVATIVE; 2 PROPIONYLPYRIDINE THIOSEMICARBAZONE DERIVATIVE; THIOSEMICARBAZIDE DERIVATIVE; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DOSE RESPONSE; DRUG ANALYSIS; DRUG COMPARISON; DRUG RESPONSE; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; INFRARED SPECTROMETRY; MOUSE; NUCLEAR MAGNETIC RESONANCE; PLASMODIUM BERGHEI; PROTOZOON; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION; THEORETICAL STUDY;

ANIMALS; ANTIMALARIALS; MALARIA; MICE; PLASMODIUM BERGHEI; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOSEMICARBAZONES;

EID: 0018729344     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00193a020     Document Type: Article

References (35)

1. G. Domagk, R. Behnisch, F. Mietzsch, and H. Schmidt, Naturwissenschaften, 33, 315 (1946).
2. D.J. Drain, C.L. Goodacre, and D.E. Seymour, J. Pharm. Pharmacol, 1, 784 (1949).
3. R. Protivinsk Antibiot. Chemother. (Basel), 17, 101 (1971).
4. W.H. Wagner and E. Winkelmann, Arzneim Forsch., 22, 1713 (1972).
5. A. Lewis and R.G. Shepherd in ‘Medicinal Chemistry’ A. Burger, Ed., Wiley, New York, 1970, p 431.
6. P. Malatesta, G.P. Accinelli, and G. Quaglia, Ann. Chim. (Rome), 49, 397 (1959).
7. J. Kolancy, N. Stimac, B. Sajko. B. Balenovic, and B. Urbas. Arh. Kem., 26, 71 (1954).
8. J.C. Logan, M.P. Fox, J.H. Morgan, A.M. Makohon, and C.J. Pfau, J. Gen. Virol. 28, 271 (1975).
9. R.L. Thompson, S.A. Minton, Jr., J.E. Officer, and G.H. Hitchings, J. Immunol., 70, 229 (1953).
10. D.H. Jones, R. Slack, S. Squires, and K.R.H. Wooldridge, J. Med. Chem., 8, 676 (1965).
11. E. Winkelmann and H. Rollv. Arzneim.-Forsch. 22, 1704 (1972).
12. A. Kaminski, Prensa Med. Argent., 40, 1263 (1953).
13. H.R. Wilson, G.R. Revankar, and R.L. Tolman. J. Med. Chem., 17, 760 (1974).
14. E. Winkelmann, W.-H. Wagner, and H. Wirth. Arsneim.-Forsch., 27, 950 (1977).
15. R.W. Brockman, J.R. Thomson, M.J. Bell, and H.E. Skipper, Cancer Res., 16, 167 (1956).
16. A. Giner-Sorolla, M. McCravey, J. Longlev-Cook, and J.H. Burchenal, J. Med. Chem. 16, 984 (1973).
17. K.C. Agrawal, A.J. Lin, B.A. Booth, J.R. Wheaton, and A.C. Sartorelli, J. Med. Chem., 17, 631, (11) 74.
18. K.C. Agrawal, B.A. Booth, S.M. DeNuzzo, and A.C. Sartorelli, J. Med. Chem., 18, 368 (1975).
19. W.J. Dunn and E.M. Hodnett, Eur. J. Med. Chem., Chim. Ther., 12, 113 (1977).
20. L.-F. Lin, S.-J. Lee, and C.T. Chen, Heterocycles, 7. 547 (1977).
21. M.T. Martinez Aguilar, J.M. Cano Pavon, and F. Pino, Anal. Chim. Acta, 90, 335 (1977).
22. J. Klarer and R. Behnisch, German Patent 832 891 (1952); Chem. Abstr., 47, 3342 (1953).
23. M. Tisler, Croat. Chem. Acta, 27, 147 (1956); Chem. Abstr., 51 12016 (1957).
24. ( 16) P.C. Guha and H.P. Ray, J. Am. Chem. Soc., 47, 385 (1925).
25. E. Lieber and J, Ramachandran, Can. J. Chem., 37, 101 (1959).
26. E. Hoggarth, J. Chem. Soc., 1579 (1950).
27. K.A. Jensen, T.J. Anthoni, B. Kigi, C. Larsen, and C.T. Pedersen. Acta Chem. Scand., 22, 1 (1968).
28. S. Sallay and S.J. Childress, U.S. Patent 3 406 180 (1968); Chem. Abstr. 70, 11223 (1969).
29. E. Lieber and R. Slutkin, J. Org. Chem., 27, 2214 (1962).
30. E. Lieber. C.N. Pillai, and R.D. Hite, Can. J. Chem., 35, 832 (1957).
31. F.E. Anderson, C.J. Duca, and J.V. Scudi, J. Am. Chem. Sia., 73, 4967 (1951).
32. P. Hemmerich, B. Prijs, and H. Erlenmeyer, Helv. Chim. Acta, 41, 2058 (1958).
33. Based on the method of L.F. Audrieth, E.S. Scott, and P.S. Kippur, J. Org. Chem., 19, 733 (1954).
34. T.R. Gardner, F.A. Smith, E. Wenis, and J. Lee, J. Org. Hern. 21, 530 (1956).
35. T.S. Osdene, P.B. Russell, and L. Rane, J. Med. Chem., 21, 530 (1956).