The relationship between sister chromatid exchange, chromosome aberration and gene mutation induction by several reactive polycyclic hydrocarbon metabolites in cultured mammalian cells

International Journal of Cancer

Volumn 24, Issue 4, 1979, Pages 485-489

  Connell, Jane R ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

8 AZAGUANINE; BENZO[A]PYRENE 4,5 OXIDE; BROXURIDINE; DRUG METABOLITE;

7 BROMOMETHYLBENZ[A]ANTHRACENE; 7,8,9,10 TETRAHYDRO 7BETA,8ALPHA DIHYDROXYBENZO[A]PYRENE 9ALPHA,10ALPHA OXIDE; 7,8,9,10 TETRAHYDRO 7BETA,8ALPHA DIHYDROXYBENZO[A]PYRENE 9BETA,10BETA OXIDE; ANIMAL EXPERIMENT; CELL CULTURE; CYTOCHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG COMPARISON; DRUG RESPONSE; DRUG SCREENING; GENE MUTATION; HAMSTER; HEREDITY; IN VITRO STUDY; SISTER CHROMATID EXCHANGE;

ANIMAL; AZAGUANINE; BENZANTHRACENES; BENZOPYRENES; CELL LINE; CELL SURVIVAL; CHROMOSOME ABERRATIONS; CROSSING OVER (GENETICS); EPOXY COMPOUNDS; HAMSTERS; MUTATION; SISTER CHROMATID EXCHANGE;

EID: 0018696930     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.2910240417     Document Type: Article

References (23)

1. Chromosome aberrations and sister chromatid exchanges in Chinese hamster cells exposed to various chemicals
2. The human leukocyte test system. VI. The use of sister chromatid exchanges as possible indicators for mutagenic activities
3. Tumorigenicity of the optical enantiomers of the diastereomeric benzo(a)‐pyrene 7,8‐diol‐9,10‐epoxides in newborn mice: exceptional activity of (+)‐7β,8α‐dihydroxy‐9α,10α‐epoxy‐7,8,9,10‐tetrahydrobenzo(a) pyrene
4. Sister chromatid exchange as an indicator of mutagenesis
5. Reaction of 7‐bromomethylbenz(a)anthracene with nucleic acids, polynucleotides and nucleosides
6. Structure and activity in chemical carcinogenesis: reactivity and carcinogenicity of 7‐bromomethylbenz(a)anthracene and 7‐bromomethyl‐12‐methylbenz(a)anthracene
7. What are sister chromatid exchanges?
8. Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells
9. Role of sister chromatid exchanges in chromatid aberration formation
10. Tumorigenicity studies with diol‐epoxides of benzo(a)pyrene which indicate that (±)‐trans‐7β,8α‐dihydroxy‐9α,10α‐epoxy‐7,8,9,10‐tetrahydro‐benzo (a)pyrene is an ultimate carcinogen in newborn mice
11. Sister chromatid exchanges induced by mitomycin C: a new method of detecting DNA damage at chromosomal level
12. Spontaneous sister chromatid exchanges detected by a BudR‐labelling method
13. Sister chromatid exchanges in Vicia faba. II. Effect of thiotepa, caffeine and 8‐ethoxy caffeine on the frequency of SCE's
14. Sister chromatid exchanges, indices of human chromosome damage and repair: detection by fluorescence and induction by mitomycin C.
15. Induction by alkylating agents of sister chromatid exchanges and chromatid breaks in Fanconi's anemia
16. Exceptional mutagenicity of benzo(a)pyrene diolepoxide in cultured mammalian cells
17. A quantitative comparison of the mutagenicity of carcinogenic polycyclic hydrocarbon derivatives in cultured mammalian cells
18. Induction of sister chromatid exchanges in Chinese hamster ovary cells cells treated in vitro with the non‐K‐region dihydrodiols of 7‐methylbenz‐(a)anthracene and benzo(a)pyrene
19. Cytological detection of mutagen‐carcinogen exposure by sister chromatid exchange
20. New Giemsa method for the differential staining of sister chromatids
21. Sister chromatid exchange
22. The induction of chromatid deletions in accord with the breakage and reunion hypothesis
23. Sister chromatid exchanges induced by mutagenic carcinogens in normal and Xeroderma pigmentosum cells