Improved Antitumor Effects in 3'-Branched Homologs of 2'-Deoxythioguanine. Synthesis and Evaluation of Thioguanine Nucleosides of 2, 3-Dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose

Journal of Medicinal Chemistry

Volumn 22, Issue 5, 1979, Pages 518-525

  Acton, Edward M ^a   Goemer, Richard N ^a   Uh, Hong S ^a   Ryan, Kenneth J ^a   Henry, David W ^a   Cass, Carol E ^b   LePage, Gerald A ^b  

^a SRI INTERNATIONAL   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2' DEOXYTHIOGUANOSINE DERIVATIVE; DEOXYTHIOGUANOSINE; DRUG DERIVATIVE; RADIOISOTOPE; THIOGUANINE DERIVATIVE S 35; TYROSINE ESTER DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL GROWTH; DRUG ANALYSIS; DRUG COMPARISON; DRUG METABOLISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; HUMAN CELL; IN VITRO STUDY; INFRARED SPECTROMETRY; INTRAPERITONEAL DRUG ADMINISTRATION; LYMPHOBLAST; LYMPHOSARCOMA; MOUSE; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; THEORETICAL STUDY; THIN LAYER CHROMATOGRAPHY; TUMOR; ULTRAVIOLET SPECTROPHOTOMETRY;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; DEOXYGUANOSINE; DNA, NEOPLASM; FEMALE; HUMANS; LYMPHOCYTES; LYMPHOMA, NON-HODGKIN; MICE; NEOPLASMS, EXPERIMENTAL; STRUCTURE-ACTIVITY RELATIONSHIP; THIONUCLEOSIDES;

EID: 0018669270     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00191a012     Document Type: Article

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