Disposition of tetrachloro(14C)ethylene following oral and inhalation exposure in rats

Toxicology and Applied Pharmacology

Volumn 51, Issue 3, 1979, Pages 465-474

  Pegg, D G ^a   Zempel, J A ^a   Braun, W H ^a   Watanabe, P G ^a  

^a DOW CHEMICAL COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXALIC ACID; OXALIC ACID DERIVATIVE; TETRACHLOROETHYLENE; THIOL DERIVATIVE;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; DRUG ADMINISTRATION; DRUG BINDING; INHALATIONAL DRUG ADMINISTRATION; KIDNEY; LIVER; LUNG CLEARANCE; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; RADIOIMMUNOASSAY; RAT; SOFT TISSUE; TETRACHLOROETHYLENE C 14; ANIMAL; ARTICLE; GAS; HALF LIFE TIME; KINETICS; MALE; METABOLISM; PROTEIN BINDING; URINE;

ADMINISTRATION, ORAL; ANIMAL; GASES; HALF-LIFE; KINETICS; LIVER; MALE; OXALATES; PROTEIN BINDING; RATS; SULFHYDRYL COMPOUNDS; TETRACHLOROETHYLENE;

EID: 0018653235     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/0041-008X(79)90371-5     Document Type: Article

References (18)

1. Chemical reactivity, metabolic oxirane formation and biological reactivity of chlorinated ethylenes in the isolated perfused rat liver preparation
2. Gas chromatographic-mass spectrometric method for the determination of perchloroethylene and its major metabolites in urine
3. 36Cl-labeled trichloroethylene and tetrachloroethylene in the rat
4. Contribution to the metabolism of tetrachloroethyelne
5. Pharmacokinetic studies in evaluation of the toxicological and environmental hazards of chemicals
6. A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. I. Correlation of changes in covalent binding of reactive metabolites with changes in the incidence and severity of toxicity
7. A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding
8. Mutagenicity in vitro and potential carcinogenicity of chlorinated ethylene as a function of metabolic oxirane formation
9. A rapid and simple procedure for chronic cannulation of the rat jugular vein
10. Protein measurement with the Folin phenol reagent
11. Enhancement of the metabolism and hepatotoxicity of trichloroethylene and perchloroethylene
12. Estimation of total protein bound and nonprotein sulfhydryl groups in tissue with Ellman's reagent
13. Acute tetrachloroethylene intoxication
14. Experimental human exposure to tetrachloroethylene
15. Accidental vapor exposure to anesthetic concentrations of a solvent containing tetrachloroethylene
16. Human exposure to tetrachloroethylene vapor
17. 14C-tetrachloroethylene in mice