Potential pitfalls in the conventional pharmacokinetic studies: Effects of the initial mixing of drug in blood and the pulmonary first-pass elimination

Journal of Pharmacokinetics and Biopharmaceutics

Volumn 7, Issue 5, 1979, Pages 527-536

  Chiou, Win L ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

instantaneous distribution; pharmacokinetics; pulmonary first pass effect

Indexed keywords

DIAZEPAM; DIGITOXIN; DIGOXIN; DISOPYRAMIDE; FLUOROMETHANE; GENTAMICIN; IOPANOIC ACID; LIDOCAINE; MEDROXYPROGESTERONE; PHENYLBUTAZONE; PROSTAGLANDIN F2 ALPHA;

CARDIOVASCULAR SYSTEM; DOSE TIME EFFECT RELATION; DRUG CLEARANCE; DRUG CONCENTRATION; DRUG EFFICACY; DRUG ELIMINATION; LUNG; PHARMACOKINETICS; PLASMA; RESPIRATORY SYSTEM; REVIEW;

ANIMAL; BIOTRANSFORMATION; BLOOD PROTEINS; CARDIAC OUTPUT; HUMAN; INJECTIONS, INTRAVENOUS; KINETICS; LUNG; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; TIME FACTORS;

EID: 0018638067     PISSN: 0090466X     EISSN: 15738744     Source Type: Journal    
DOI: 10.1007/BF01062393     Document Type: Article

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