Cyclic Oscillations of Basal Plasma Glucose and Insulin Concentrations in Human Beings

New England Journal of Medicine

Volumn 301, Issue 19, 1979, Pages 1023-1027

  Lang, D A ^a   Matthews, D R ^a   Peto, J ^a   Turner, R C ^a  

^a RADCLIFFE INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

ENDOCRINE SYSTEM; HUMAN CELL; NORMAL HUMAN; NORMAL VALUE; PANCREAS; PLASMA;

EID: 0018627173     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM197911083011903     Document Type: Article

References (26)

1. Holman RR, Turner RC: Maintenance of basal plasma glucose and insulin concentrations in maturity-onset diabetes. Diabetes 28: 227–230, 1979
2. Goodner CJ, Conway MJ, Werrbach J: Control of insulin secretion during fasting hyperglycemia in adult diabetics and in nondiabetic subjects during infusion of glucose. J Clin Invest 48: 1878–1887, 1969
3. Bagdade JD, Bierman EL, Porte D Jr: Counter-regulation of basal insulin secretion during alcohol hypoglycemia in diabetic and normal subjects. Diabetes 21: 65–70, 1972
4. McCarthy ST, Harris E, Turner RC: Glucose control of basal insulin secretion in diabetes. Diabetologia 13: 93–97, 1977
5. Gagliardino JJ, Bellone CF, Doria I, et al: Adrenergic regulation of basal serum glucose, NEFA and insulin levels. Horm Metab Res 2: 318–322, 1970
6. Robertson RP, Porte D Jr: Adrenergic modulation of basal insulin secretion in man. Diabetes 22: 1–8, 1973
7. Felig P, Marliss E, Cahill GF Jr: Plasma amino acid levels and insulin secretion in obesity. N Engl J Med 281: 811–816, 1969
8. Floyd JC Jr, Fajans SS, Conn JW, et al: Secretion of insulin by amino acids and glucose in diabetes mellitus. J Clin Endocrinol Metab 28: 266–276, 1968
9. Felig P, Wahren J: The liver as site of insulin and glucagon action in normal, diabetic and obese humans. Isr J Med Sci 11: 528–539, 1975
10. Brown CM, Tompkins CV, Juul S, et al: Mechanism of action of insulin in diabetic patients: a dose-related effect on glucose production and utilisation. Br Med J 1: 1239–1242, 1978
11. Jennings AS, Cherrington AD, Liljenquist JE, et al: The roles of insulin and glucagon in the regulation of gluconeogenesis in the postabsorptive dog. Diabetes 26: 847–856, 1977
12. Unger RH, Dobbs RE, Orci L: Insulin, glucagon, and somatostatin secretion in the regulation of metabolism. Annu Rev Physiol 40: 307–343, 1978
13. Bucolo RJ, Bergman RN, Marsh DJ, et al: Dynamics of glucose autoregulation in the isolated, blood-perfused canine liver. Am J Physiol 227: 209–217, 1974
14. Liljenquist JE, Mueller GL, Cherrington AD, et al: Hyperglycemia per se (insulin and glucagon withdrawn) can inhibit hepatic glucose production in man. J Clin Endocrinol Metab 48: 171–175, 1979
15. Turner RC, Holman RR: Insulin rather than glucose homeostasis in the pathophysiology of diabetes. Lancet 1: 1272–1274, 1976
16. Goodner CJ, Walike BC, Koerker DJ, et al: Insulin, glucagon, and glucose exhibit synchronous, sustained oscillations in fasting monkeys. Science 195: 177–179, 1977
17. Matthews DR, Lang DA, Peto J, et al: Cyclical variation (“hunting”) of basal plasma glucose and insulin concentrations in normal and diabetic man. Diabetologia 15: 254, 1978
18. Albano JDM, Ekins RD, Maritz G, et al: A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free moieties. Acta Endocrinol (Copenh) 70: 487–509, 1972
19. Holman RR, Turner RC: Diabetes: the quest for normoglycaemia. Lancet 1: 469–474, 1977
20. Chirlian PM: Signals, Systems and the Computer. New York, Intex Educational Publishers, 1973, pp 73–74
21. Kendall MG, Stuart A: The Advanced Theory of Statistics. Vol 3. London, Charles Griffen and Company, 1968, pp 361–362
22. Horwitz DL, Starr JI, Mako ME, et al: Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood. J Clin Invest 55: 1278–1283, 1975
23. Sabine E: On the atmospheric tide at St Helena. Philos Trans R Soc Lond 137: 45–50, 1847
24. Dawson GD: A summation technique for the detection of small evoked potentials. Electroencephalogr Clin Neurophysiol 6: 65–84, 1954
25. Goebelsmann U, Midgley AR Jr, Haffe RB: Regulation of human gonadotropins. VII. Daily individual urinary estrogens, pregnanediol and serum luteinizing and follicle stimulating hormones during the menstrual cycle. J Clin Endocrinol 29: 1222–1230, 1969
26. Stagner J, Samols E, Weir G: Detection of sustained insulin, somatostatin and glucagon oscillations in the isolated perfused canine pancreas. Presented at the 61st annual meeting of the Endocrine Society, Anaheim, California, June 13–15, 1979