Perinatal toxicity of maneb, ethylene thiourea, and ethylenebisisothiocyanate sulfide in rodents

Journal of Toxicology and Environmental Health

Volumn 5, Issue 5, 1979, Pages 821-834

  Chernoff, Neil ^a   Kavlock, Robert J ^a   Rogers, Ellen H ^a   Carver, Brenda D ^a   Murray, Sharon ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 IMIDAZOLIDINETHIONE; ETHYLENE BIS(ISOTHIOCYANATE) SULFIDE; MANEB; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; BONE; CENTRAL NERVOUS SYSTEM; CONGENITAL DISORDER; CONGENITAL MALFORMATION; DOSE RESPONSE; DRUG COMPARISON; DRUG EXPOSURE; DRUG RESPONSE; DRUG TOXICITY; EMBRYO; FETUS; GUINEA PIG; HAMSTER; HYDROCEPHALUS; INTOXICATION; LIMB; MOUSE; MUSCULOSKELETAL SYSTEM; NEWBORN; ORAL DRUG ADMINISTRATION; PARALYSIS; PREGNANCY; RAT; TERATOGENICITY; THEORETICAL STUDY;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; BEHAVIOR, ANIMAL; CRICETINAE; ETHYLENETHIOUREA; FEMALE; FETUS; GESTATIONAL AGE; GUINEA PIGS; IMIDAZOLES; MANEB; MESOCRICETUS; MICE; PREGNANCY; RATS; SPECIES SPECIFICITY; THIOCARBAMATES; THIOCYANATES;

ANIMALIA; CAVIA; CAVIA PORCELLUS; CRICETINAE; RODENTIA; SUS SCROFA;

EID: 0018598992     PISSN: 00984108     EISSN: None     Source Type: Journal    
DOI: 10.1080/15287397909529792     Document Type: Article

References (16)

1. Bontoyan, W. R. and Looker, J. B. 1973. Degradation of commercial ethylenebisdithiocarbamate formulations to ethylenethiourea under elevated temperature and humidity. J. Agric. Food Chem. 21:338-341.
2. Fishbein, L. 1976. Environmental health aspects of fungicides. I. Dithiocarbamates. J. Toxicol. Environ. Health 1:713-735.
3. Jonckheere, A. R. 1954. A distribution-free-K-sample test against ordered alternatives. Biometrika 41:133-145.
4. Hayes, W. J. 1976. Dosage relationships associated with DDT in milk. Toxicol. Appl. Pharmacol. 38:19-28.
5. Khera, K. S. 1973. Ethylenethiourea: Teratogenicity study in rats and rabbits. Teratology 7:243-252.
6. Khera, K. S. and Tryphonas, L. 1977. Ethylenethiourea-induced hydrocephalus: Pre- and postnatal pathogenesis in offspring from rats given a single oral dose during pregnancy. Toxicol. Appl. Pharmacol. 42:85-97.
7. Larsson, K. S., Arander, C., Cekanova, E., and Kjellberg, M. 1976. Studies of teratogenic effects of the dithiocarbamates maneb, mancozeb, and propineb. Teratology 14:171-184.
8. Lyman, W. R. and Lacoste, R. J. 1975. New developments in the chemistry and rate of ethylenebisdithiocarbamate fungicides. In Environmental Quality and Safety Supplement: Vol. 3. Pesticides, eds. F. Coulston and F. Korte, pp. 67-74. International Union of Pure and Applied Chemistry 3d Int. Congr., Helsinki, Finland, July 3-9. Stuttgart: Thieme.
9. Newsome, W. H. 1974. The excretion of ethylenethiourea by rat and guinea pig. Bull. Environ. Contam. Toxicol. 11:174-176.
10. Petrova-Vergieva, T. and Ivanova-Tchemishanska, L. 1973. Assessment of the teratogenic activity of dithiocarbamate fungicides. Food Cosmet. Toxicol. 11:239-244.
11. Ruddick, J. A. and Khera, K. S. 1975. Pattern of anomalies following single oral doses of ethylenethiourea to pregnant rats. Teratology 12:277-282.
12. Ruddick, J. A., Newsome, W. H., and Nash, L. 1976. Correlation of teratogenicity and molecular structure: Ethylenethiourea and related compounds. Teratology 13:263-266.
13. Ruddick, J. A., Newsome, W. H., and Iverson, F. 1977. A comparison of the distribution, metabolism and excretion of ethylenethiourea in the pregnant mouse and rat. Teratology 16:159-162.
14. Seidler, H., Schnaak, W., and Engst, R. 1970. Untersuchungen uber den Metabolismus einiger Insektizide und Fungizide in der Ratte. 2. Verteilung und Abbau von 14C-markiertem Maneb. Nahrung 14:363-373.
15. Sobotka, T. J., Brodie, R. E., and Cook, M. P. 1972. Behavioral and neuroendocrine effects in rats of postnatal exposure to low dietary levels of maneb. Dev. Psychobiol. 5:137-148.
16. Sokal, R. and Rohlf, F. 1969. Biometry. San Francisco: Freeman.