Evidence that an excitatory connection between the periaqueductal gray and nucleus raphe magnus mediates stimulation produced analgesia

Brain Research

Volumn 170, Issue 1, 1979, Pages 85-93

  Behbehani, Michael M ^a,b   Fields, Howard L ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID; MORPHINE; NALOXONE;

ANALGESIA; BRAIN DEPTH STIMULATION; CENTRAL NERVOUS SYSTEM; INTRACEREBRAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; NERVE CELL; NERVOUS SYSTEM; PERIAQUEDUCTAL GRAY MATTER; RAPHE MAGNUS NUCLEUS; RAPHE NUCLEUS; RAT;

ANIMAL; AXONS; BRAIN STEM; CEREBRAL AQUEDUCT; ELECTRIC STIMULATION; GLUTAMATES; HINDLIMB; MALE; MUSCLE CONTRACTION; NALOXONE; NEURAL INHIBITION; NEURAL PATHWAYS; NEURONS; NOCICEPTORS; RAPHE NUCLEI; RATS; RECEPTORS, OPIOID; REFLEX;

EID: 0018420264     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(79)90942-9     Document Type: Article

References (29)

1. Monoaminergic mechanisms of stimulation produced analgesia
2. Antagonism of stimulation produced analgesia by naloxone, a narcotic antagonist
3. Opiate and stimulus produced analgesia: functional anatomy of a medullospinal pathway
4. Three bulbospinal pathways from the rostral medulla of the cat: an autoradiographic study of pain modulating systems
5. The dorsolateral funiculus of the spinal cord: A major route for descending brain stem control
6. Reversal of morphine and stimulus produced analgesia by subtotal spinal cord lesions
7. Inhibition of primate spinothalamic tract neurons by stimulation in the region of nucleus raphe magnus
8. Effect of morphine injected in the periaqueductal gray on the activity of single units in nulceus raphe magnus of the rat
9. Modification of dorsal horn cell activities in the spinal cord after intra-arteria injection of brakinin
10. Evidence for the existence of monoamine neurons in the central nervous system. II. Experimentally induced changes in the intraneuronal amine levels of the bulbo-spinal neuron system
11. Evidence that raphe-spinal neurons mediate opiate and midbrain stimulation produced analgesia
12. Brain control of spinal pain transmission neurons
13. Nucleus raphe magnus inhibition of spinal dorsal neuron
14. Afferents to brain stem nuclei (brain stem raphe nucleus reticularis pontis caudalis and nucleus gigantocellularis) in the rat as demonstrated by microiontophoretically applied horseradish peroxidase
15. Reduction of stimulation-produced analgesia by lysergic acid diethylamide, a depressor of serotonergic neural activity
16. Pain relief by electrical stimulation of the central gray matter in human and its reversal by naloxone
17. Evaluation of the periaqueductal central gray (PAG) as a morphine-specific locus of action and examination of morphine-induced and stimulation-produced analgesia at coincident PAG loci
18. Pain reduction by focal electrical stimulation of the brain. An anatomical and behavioral analysis
19. Central nervous system mechanisms of analgesia
20. Analgesia from electrical stimulation in the brainstem of the rat
21. Effect of pain-attenuating brain stimulation and morphine on electrical activity in the raphe nuclei of the awake rat
22. Behavioral and electrophysiological evidence of pain inhibition from midbrain stimulation in the cat
23. Topographical atlas of catecholamine and acetylcholinesterase-containing neurons in the rat brain. II. Hindbrain (mesencephalon, rhombencephalon),
24. Surgery in the rat during electrical analgesia induced by focal brain stimulation
25. Autoradiographic Examination of the Efferent Projections of the Midbrain Central Gray in the Cat
26. Pain-induced alteration of glutamate in periaqueductal central gray and its reversal by morphine
27. The effect of lowering the 5-hydroxytryptamine content of the rat spinal cord on analgesia produced by morphine
28. Antagonism by methysergide and cinanserin of the antinociceptive action of morphine administered into the periaqueductal gray