Inactivation of metronidazole by aerobic organisms

Journal of Antimicrobial Chemotherapy

Volumn 5, Issue 3, 1979, Pages 315-316

  Edwards, D I ^a   Thompson, E J ^a   Tomusange, J ^a   Shanson, D ^b  

^a UNIVERSITY OF EAST LONDON   (United Kingdom)

^b CHELSEA AND WESTMINSTER HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

METRONIDAZOLE; MISONIDAZOLE;

DRUG RESISTANCE; DRUG THERAPY; EDITORIAL; FEMALE GENITAL SYSTEM; PROTOZOON; THERAPY; TRICHOMONAS VAGINALIS; VAGINA FLORA; VAGINITIS;

AEROBIOSIS; CANDIDA ALBICANS; ENTEROBACTERIACEAE; ENTEROCOCCUS FAECALIS; FEMALE; HUMAN; METRONIDAZOLE; NITROIMIDAZOLES; OXIDATION-REDUCTION; VAGINA;

EID: 0018374706     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/5.3.315     Document Type: Letter

References (13)

1. Buchner, V. and Edwards, D. I. The effect of metronidazole and nitrofurans on the morphology of Trichomonas vaginalis. Journal of Antimicrobial Chemotherapy 1: 229-34 (1975).
2. Edwards, D. I. The action of metronidazole on DNA. Journal of Antimicrobial Chemotherapy 3: 43-8 (1977).
3. Edwards, D. I. and Mathison, G. E. The mode of action of metronidazole against Trichomonas vaginalis. Journal of General Microbiology 63: 297-302 (1970).
4. Edwards, D. I., Dye, M. and Crane, H. The selective toxicity of antimicrobial nitroheterocyclic drugs. Journal of General Microbiology 76: 135-45 (1973).
5. Edwards, D. I., Knight, R. C. and Kantor, I. Interaction of nitroimidazole drugs with DNA. Current Chemotherapy 1: 714-16 (1978).
6. Ings, R. J. M., McFadzean, J. A. and Ormerod, J. A. The mode of action of metronidazole in Trichomonas vaginalis and other micro-organisms. Biochemical Pharmacology 23: 1421-9 (1974).
7. Kane, P. O., McFadzean, J. A. and Squires, S. Absorption and excretion of metronidazole, part II: studies on primary failures. British Journal of Venereal Diseases 37: 276-7 (1961).
8. Knight, R. C., Skolimowski, I. M. and Edwards, D. I. Interaction of reduced metronidazole with DNA. Biochemical Pharmacology 27: 2089-93.
9. McFadzean, J. A., Pugh, I. M., Squires, S. and Whelan, J. P. F. Further observations on strain sensitivity of Trichomonas vaginalis to metronidazole. British Journal of Venereal Disease 45; 161-2 (1969).
10. Müller, M., Lindmark, D. G. and McLaughlin, J. Mode of action of nitroimidazoles on tricho- monads in Biochemistry of Parasites and Host-Parasite Relationships. North-Holland, Amsterdam (1976), pp. 537-44.
11. Nicol, C. S., Evans, A. J., McFadzean, J. A. and Squires, S. Trichomonas vaginalis resistance. Lancet 1: 1100-1101 (1966).
12. Plant, C. W. and Edwards, D. I. The effect of tinidazole, metronidazole and nitrofurazone on nucleic acid synthesis in Clostridium bifermen- tans. Journal of Antimicrobial Chemotherapy 2: 203-9(1976).
13. Squires, S. and McFadzean, J. A. Strain sensitivity of Trichomonas vaginalis to metronidazole. British Journal of Venereal Disease 38: 218-19 (1962).