Synthesis of New Water-soluble Dihydropyridine Vasodilators

Chemical and Pharmaceutical Bulletin

Volumn 27, Issue 6, 1979, Pages 1426-1440

  Iwanami, Masaru ^a   Shibanuma, Tadao ^a   Fujimoto, Masaharu ^a   Kawai, Ryutaro ^a   Tamazawa, Kazuharu ^a   Takenaka, Toichi ^a   Takahashi, Kozo ^a   Murakami, Masuo ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

asymmetric; dihydropyridine; ester; Hantzch reaction; Nifedipine; vasodilating activity; vasodilators

Indexed keywords

1,4 DIHYDROPYRIDINE DERIVATIVE; NICARDIPINE; PAPAVERINE;

ANIMAL EXPERIMENT; DOG; DRUG ANALYSIS; DRUG COMPARISON; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; THEORETICAL STUDY; VASODILATATION;

NICARDIPINE; NIFEDIPINE; PYRIDINES; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; VASODILATOR AGENTS; WATER;

EID: 0018366692     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.27.1426     Document Type: Article

References (21)

1. Location: Azusawa 1-1-8, Itabashi Ku, Tokyo 174, Japan.
2. A. Hantzch, Ann. Chim., 215, 1 (1882).
3. F. Bossert and W. Yater, Naturwissenschaften, 58, 578 (1971).
4. S.S. Walkenstein, A.P. Inotoccia, T.L. Flanagan, B. Hawang, D. Flint, J. Villani, D. Blackburn, J. Weinstock, and H. Green, J. Pharm. Sci., 62, 580 (1973)
5. B. Loev, M.M. Goodman, K.M. Snader, R. Tedeschi, and E. Marco. J. Med. Chem., 17, 956 (1974).
6. R. Gompper and H.U. Wagner, Angew. Chem. Int. Ed. Engl. 15, 321 (1976).
7. J. Blunken and G. Glocken, Ger. Patent 15024 (1960).
8. D.A. Tomalia and J.C. Falk, J. Hetevocycl. Chem., 9, 891 (1972).
9. “Organic Synthesis,” Coll. Vol. II, ed. by A.H. Blatt, John Willey and Sons, Inc., New York, 1963, p. 91.
10. A.C. Cope, J. Am. Chem. Soc., 74, 611 (1952).
11. F. Bossert, H. Meyer, and W. Vater, Ger. Patent 218664 (1974).
12. A. Sausins, V. Lusis, B. Cekavicious, and G. Duburs, Khim. Geterotsikl. Soedin., 2, 272 (1978).
13. L.I. Smith and M. Bayliss, J. Org. Chem., 6, 437 (1941).
14. H. Gilman, J. Tolman, F. Yeoman, L.A. Woods, D.A. Shireley, and S. Avakin, J. Am. Chem. Soc., 68, 426 (1946).
15. S. Higuchi, H. Sasaki, Y. Shiobara, and T. Sado, Xenobiotica., 7, 469 (1977).
16. S. Higuchi, H. Sasaki, Y. Shiobara, and T. Sado, Yamanouchi Kenkyujyo Hokoku., 3, 175 (1977).
17. M. Iwanami, M. Murakami, K. Takahashi, M. Fujimoto, T. Shibanuma, R. Kawai, and T. Takenaka, Jpn. Patent (Kokai) 109384 (1974).
18. T. Takenaka, Kiso to Rinsho., 8, 51 (1974).
19. “Organic Synthesis,” Vol. 42, Ed. by Virgil Boeklheide, John Wiley and Sons, Inc., New York, 1963, p. 28.
20. S.A. Glickmann and A.C. Cope, J. Am. Chem. Soc., 67, 1019 (1954).
21. The radioactive material was provided by Daiichi Pure Chemicals Ltd., Tokyo.