Spontaneous vs. naloxone-induced abstinence in dependent rats self-administering L-Alpha-Acetylmethadol (LAAM) or morphine

Pharmacology, Biochemistry and Behavior

Volumn 10, Issue 4, 1979, Pages 585-589

  Young, Gerald A ^a   Steinfels, George F ^a   Khazan, Naim ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

Abstinence; LAAM Self Administration; Lever pressing; REM sleep

Indexed keywords

ACETYLMETHADOL; MORPHINE; NALOXONE;

ANIMAL EXPERIMENT; DRUG COMPARISON; DRUG DEPENDENCE; DRUG RESPONSE; INTRAVENOUS DRUG ADMINISTRATION; PHARMACOKINETICS; RAT; REM SLEEP; SELF MEDICATION; WITHDRAWAL SYNDROME;

ANIMAL; FEMALE; HUMAN; METHADONE; METHADYL ACETATE; MORPHINE DEPENDENCE; NALOXONE; RATS; SELF ADMINISTRATION; SLEEP, REM; SUBSTANCE WITHDRAWAL SYNDROME; SUBSTANCE-RELATED DISORDERS; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS;

EID: 0018358226     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/0091-3057(79)90237-5     Document Type: Article

References (14)

1. Headshake distributions during self-maintained dependence on morphine, methadone and l-alpha-acetylmethadol (LAAM) in the rat
2. Paradoxical absence of aggression during naloxone-precipitated morphine withdrawal
3. Accumulation of l-α-acethylmethadol (LAAM) and active metabolites in plasma following chronic administration
4. Disposition of acetylmethadol in relation to pharmacologic action
5. The implication and significance of EEG and sleep-awake activity in the study of experimental drug dependence on morphine
6. Decline in the mean integrated electroencephalogram voltage during morphine abstinence in the rat
7. Protracted rebound in rapid eye movement sleep time and electroencephalogram voltage output in morphine-dependent rats upon withdrawal
8. The electroencephalogram and the electromyogram of self-maintained morphine addicted rats in relation to injections
9. Electroencephalographic, electromyographic and behavioral correlates during a cycle of self-maintained morphine addiction in the rat
10. Plasma levels of l-α-acetylmethadol (LAAM) and metabolites following acute and chronic oral administration in man
11. Drug self-administration and slee-awake activity in rats dependent on morphine, methadone, or l-alpha-acetylmethadol
12. Experimental morphine addiction: Methods for automatic intravenous injections in unrestrained rats
13. Long-term intravenous infusion
14. l-alpha-acetylmethadol (LAAM), methadone, and morphine abstinence in dependent rats: EEG and behavioral correlates