3H-spiroperidol binding to dopamine receptors in rat striatal membranes: Influence of loxapine and its hydroxylated metabolites

European Journal of Pharmacology

Volumn 55, Issue 2, 1979, Pages 215-218

  Coupet, Joseph ^a   Rauh, Charles E ^a  

^a WYETH RESEARCH   (United States)

Author keywords

7 Hydroxyloxapine; 3H Spiroperidol; Antipsychotics; Dopamine receptor; Loxapine

Indexed keywords

CHLORPROMAZINE; CLOZAPINE; DOPAMINE RECEPTOR; HALOPERIDOL; LOXAPINE; POSTSYNAPTIC RECEPTOR; RADIOISOTOPE; SPIPERONE; BUTYROPHENONE DERIVATIVE; DIBENZOXAZEPINE DERIVATIVE;

ANIMAL EXPERIMENT; CENTRAL NERVOUS SYSTEM; CORPUS STRIATUM; DRUG BINDING; DRUG COMPARISON; DRUG INTERACTION; HYDROXYLOXAPINE; IN VITRO STUDY; PHARMACOKINETICS; RAT; SPIPERONE H 3; ANIMAL; ARTICLE; DRUG EFFECT; HYDROXYLATION; MEMBRANE; METABOLISM;

ANIMAL; BUTYROPHENONES; CHLORPROMAZINE; CLOZAPINE; CORPUS STRIATUM; DIBENZOXAZEPINES; HALOPERIDOL; HYDROXYLATION; IN VITRO; LOXAPINE; MEMBRANES; RATS; RECEPTORS, DOPAMINE; SPIPERONE;

EID: 0018332474     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(79)90396-0     Document Type: Article

References (11)

1. 3H-spiroperidol on rat striatal membranes
2. Effects of Loxapine (Lox) and its metabolites on dopamine-sensitive adenylate cyclase (AC) of rat striatal homogenates
3. The effect of 2-chloro-11-(4-methyl-1-piperazinyl) dibenz[b,f][1,4]oxazepine (loxapine) and its derivatives on the dopamine-sensitive adenylate cyclase of rat striatal homogenates
4. 3H-spiroperidol
5. Is it possible to predict the clinical effects of neuroleptic drugs (major tranquillizers) from animal data?
6. Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the "dopamine receptor"
7. Spiperone: a ligand of choice for neuroleptic receptors, I. Kinetics and characteristics of in vitro binding
8. Serotonergic component of neuroleptic receptors
9. The action of neuroleptic drugs on dopamine-stimulated adenosine cyclic-3′,5′-monophosphate production in rat neostriatum and limbic forebrain
10. 3H-spiperone binding to receptors in brain