Kinetics of human chorionic gonadotropin-induced steroidogenic response of the human testis. I. Plasma testosterone: Implications for human chorionic gonadotropin stimulation test

Journal of Clinical Endocrinology and Metabolism

Volumn 49, Issue 2, 1979, Pages 278-283

  Saez, José M ^a   Forest, Maguelone G ^a  

^a HÔPITAL DEBROUSSE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; CHORIONIC GONADOTROPIN; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMAN; KINETICS; MALE; TESTIS; TESTOSTERONE;

EID: 0018286840     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jcem-49-2-278     Document Type: Article

References (39)

1. Leach, R. B., W. O. Maddock, I. Tokuyama, C. A. Paulsen, and W. O. Nelson, Clinical studies of testicular hormone production, Recent Prog Horm Res 12: 377, 1956.
2. Kirschner, M. A., M. B. Lipsett, and D. R. Collins, Plasma ketosteroids and testosterone in man: a study of the pituitary-testicular axis, J Clin Invest 44: 657, 1965.
3. Lipsett, M. B., H. Wilson, M. A. Kirschner, S. G. Korenman, L. M. Fishman, G. A. Sarfaty, and C. W. Bardin, Studies on Leydig cell physiology and pathology: secretion and metabolism of testosterone, Recent Prog Horm Res 22: 245, 1966.
4. Saez, J. M., and J. Bertrand, Studies on testicular function in children: plasma concentrations of testosterone, dehydroepiandrosterone and its sulfate before and after stimulation with human chorionic gonadotropin, Steroids 12: 749, 1968.
5. Forest, M. G., J. M. Saez, and J. Bertrand, Assessment of gonadal function in children, Paediatrician 2: 102, 1973.
6. Rivarola, M. A., C. Bergada, and M. Cullen, hCG stimulation test in prepubertal boys with cryptorchidism, in bilateral anorchia and in male pseudohermaphroditism, J Clin Endocrinol Metab 31: 526, 1970.
7. Winter, J. S. D., S. Taraska, and C. Faiman, The hormonal response to hCG stimulation in male children and adolescents, J Clin Endocrinol Metab 34: 348, 1972.
8. Perheentupa, J., A. Dessypris, and H. Adlercreutz, Gonadotropin test of the functional capacity of Leydig cells in normal and hypogonadal boys, Clin Endocrinol (Oxf) 1: 141, 1972.
9. Weinstein, R. L., R. P. Kelch, M. R. Jenner, S. L. Kaplan, and M. M. Grumbach, Secretion of unconjugated androgens and estrogens by the normal and abnormal human testis before and after human chorionic gonadotropin, J Clin Invest 53: 1, 1974.
10. Mahoudeau, J. A., J. C. Valcke, and H. Bricaire, Dissociated responses of plasma testosterone and estradiol to human chorionic gonadotropin in adult men, J Clin Endocrinol Metab 41: 13,1975.
11. Bardin, C. W., G. T. Ross, A. B. Rifkind, C. M. Cargille, and M. B. Lipsett, Studies of the pituitary Leydig cell axis in young men with hypogonadotropic hypogonadism and hyposmia: comparison with normal men, prepuberal boys and hypopituitary patients, J Clin Invest 48: 2046, 1969.
12. Ruder, H. J., D. L. Loriaux, R. I. Sherins, and M. B. Lipsett, Leydig cell function in men with disorders of spermatogenesis, J Clin Endocrinol Metab 38: 244, 1974.
13. Vivanco, F., P. Gonzalez-Gancedo, and F. Ramos, A simple clinical test for increasing the serum testosterone response to intravenous infusion of human chorionic gonadotropin, Acta Endocrinol (Kbh) 73: 790, 1973.
14. Maurer, W., U. Volkwein, and J. Tamm, The effect of intravenously administered human chorionic gonadotrophin on plasma levels of testosterone and dihydrotestosterone in normal male subjects, Acta Endocrinol (Kbh) 72: 615, 1973.
15. Tell, G. P., F. Haour, and J. M. Saez, Hormonal regulation of membrane receptors and cell responsiveness: a review, Metabolism 27: 1566, 1978.
16. Saez, J. M., F. Haour, G. E. P. Tell, D. Gallet, and P. Sanchez, Human chorionic gonadotropin-induced Leydig cell refractoriness to gonadotropin stimulation, Mol Pharmacol 14: 1054, 1978.
17. Tsuruhara, T., M. L. Dufau, S. Cigorraga, and K. J. Catt, Hormonal regulation of testicular luteinizing hormone receptors: effects on cyclic AMP and testosterone responses in isolated Leydig cells, J Biol Chem 262: 9002, 1977.
18. Forest, M. G., A. M. Cathiard, and J. Bertrand, Total and unbound testosterone levels in the newborn and in normal and hypogonadal children: use of a sensitive radioimmunoassay for testosterone, J Clin Endocrinol Metab 36: 1132, 1973.
19. Forest, M. G., Use of highly specific antibodies against 17αOHprogesterone in a simplified non chromatographic RIA and in the simultaneous determinations of four sex hormones in human plasma, Horm Res 7: 260, 1976.
20. Midgley, A. R., Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone, Endocrinology 79: 10, 1960.
21. Rizkalla, H. T., E. Gurpide, and R. L. Vande Wiele, Metabolism of hCG in man, J Clin Endocrinol Metab 29: 92, 1969.
22. Jones, F. M., U. S. Fang, R. L. Landau, and R. Rosenfield, Direct inhibition of Leydig cell function by estradiol, J Clin Endocrinol Metab 47: 1373, 1978.
23. Rivarola, M. A., J. M. Saez, W. J. Meyer, M. E. Jenkins, and C. J. Migeon, Metabolic clearance rate and blood production rate oi testosterone and androst-4-ene-3,17-dione under basal conditions, ACTH and hCG stimulation. Comparison with urinary production rate of testosterone, J Clin Endocrinol Metab 26: 1208, 1966.
24. Kirschner, M. A., J. A. Wider, and G. T. Ross, Leydig cell function in man with gonadotropin-producing tumors, J Clin Endocrinoi Metab 30: 504, 1970.
25. 4-androstenedione, estrone, and 17β-estradiol: evidence for the action of human chorionic gonadotropin on intermediate enzymes implicated in steroid biosynthesis, J Clin Endocrinol Metab 49: 284, 1979.
26. Kirschner, M. A., F. B. Cohen, and D. Jerpersen, Estrogen production and its origin in man with gonadotropin-producing neoplasm, J Clin Endocrinol Metab 39: 112, 1974.
27. Haour, F., and J. M. Saez, Regulation of hCG of gonadotropin receptors in testicular Leydig cells: evidence for a down regulation, Mol Cell Endocrinol 7: 17, 1977.
28. Zipf, W. P., A. A. Payne, and R. P. Kelch, Dissociation of lutropininduced loss of testicular lutropin receptor and lutropin-induced desensitization of testosterone synthesis, Biochim Biophys Ada 540: 330, 1978.
29. Saez, J. M., F. Haour, and A. M. Cathiard, Early hCG-induced desensitization in Leydig cells, Biochem Biophys Res Commun 81: 552, 1978.
30. Sharpe, R. M., Gonadotrophin induced reduction in the steroidogenic responsiveness of the immature rat testis, Biochem Biophys Res Commun 76: 957, 1977.
31. Cigorraga, S. R., M. L. Dufau, and K. J. Catt, Regulation of luteinizing hormone receptors and steroidogenesis in gonadotropindesensitized Leydig cells, J Biol Chem 253: 4297, 1978.
32. Saez, J. M., A. M. Morera, and F. Haour, Hormonal induced refractoriness of steroidogenesis in testicular and adrenal cells, In Dumont, J., J. Nunez, and J. J. Van der Molen (eds.), Hormones and Cell Regulation, North Holland, Amsterdam, 1979, p. 187.
33. Chasalow, F., H. Marr, F. Haour, and J. M. Saez, Testicular steroidogenesis after hCG desensitization in rats, J Biol Chem, in press.
34. Samuels, L. T., T. Ochikawa, M. Zain-Ul-Abedin, and R. A. Huseby, Effect of diethylstilbestrol on enzymes of cryptorchid mouse testis of BALB/c mice, Endocrinology 85: 96, 1969.
35. Kalla, N. R., B. C. Nisula, R. H. Menard, and D. Loriaux, Estrogen modulation of Leydig cell function, Endocrinology [Suppl] 100: 82, 1977.
36. De Jong, F. H., A. H. Hey, and H. J. Van der Molen, Effect of gonadotropin on the secretion of oestradiol-17β and testosterone by the rat testis, J Endocrinol 57: 277, 1973.
37. Haour, F., P. Sanchez, A. M. Cathiard, and J. M. Saez, Gonadotropin receptor regulation in hypophysectomized rat Leydig cells, Biochem Biophys Res Commun 81: 547, 1978.
38. Haour, F., and J. M. Saez, Leydig-cell responsiveness to LH-hCG stimulation: mechanisms of hCG- and steroid-induced refractoriness, In McKerns, K. W. (ed.), Structure and Function of the Gonadotropins, Plenum Press, New York, 1978, p. 497.
39. Hall, P. F., Gonadotropin regulation of testicular function, In Eik- Nes, K. B. (ed.), The Androgens of the Testis, Marcel-Dekker, New York, 1970, p. 73.