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Volumn 16, Issue 6, 1978, Pages 333-343

Nonmutagenic action of cannabinoids in vitro

Author keywords

A9 Tetrahydrocannabinol; Cannabidiol; Cannabinoids; Cannabinol; Fibroblasts; Marihuana; Mutagenic

Indexed keywords

CANNABIDIOL; CANNABINOL; RADIOISOTOPE; TETRAHYDROCANNABINOL;

EID: 0018193988     PISSN: 00317012     EISSN: 14230313     Source Type: Journal    
DOI: 10.1159/000136789     Document Type: Article
Times cited : (21)

References (46)
  • 1
    • 0000179727 scopus 로고
    • Carcinogens are mutagens: A simple test system combining liver homogenates for activation and bacteria for detection
    • Ames, B.N., Durston, W.E., Yamasaki, E., and Lee, F.D.: Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection. Proc. natn. Acad. Sci. USA 70: 2281-2285 (1973).
    • (1973) Proc. Natn. Acad. Sci. USA , vol.70 , pp. 2281-2285
    • Ames, B.N.1    Durston, W.E.2    Yamasaki, E.3    Lee, F.D.4
  • 2
    • 0015591140 scopus 로고
    • An improved bacterial test system for the detection and classification of mutagens and carcinogens
    • Ames, B.N., Lee, K.O., and Durston, W.E.: An improved bacterial test system for the detection and classification of mutagens and carcinogens. Proc. natn. Acad. Sci. USA 70: 782-786 (1973).
    • (1973) Proc. Natn. Acad. Sci. USA , vol.70 , pp. 782-786
    • Ames, B.N.1    Lee, K.O.2    Durston, W.E.3
  • 3
    • 0016685233 scopus 로고
    • Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-micro some mutagenicity test
    • Ames, B.N., McCann, J., and Yamasaki, E.: Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-micro some mutagenicity test. Mutat. Res. 31: 347-363 (1975).
    • (1975) Mutat. Res , vol.31 , pp. 347-363
    • Ames, B.N.1    McCann, J.2    Yamasaki, E.3
  • 4
    • 0017175524 scopus 로고
    • A9-tetrahydrocan-nabinol. Effect on macromolecular synthesis in human and other mammalian cells
    • Blevins, R.D. and Regan, J.D.: A9-tetrahydrocan-nabinol. Effect on macromolecular synthesis in human and other mammalian cells. Archs Toxicol. 35: 127-135 (1976).
    • (1976) Archs Toxicol , vol.35 , pp. 127-135
    • Blevins, R.D.1    Regan, J.D.2
  • 6
    • 0017253510 scopus 로고
    • The inhibition of DNA synthesis by cannabinoids
    • Carchman, R.A., Harris, L.S., and Munson, A.E.: The inhibition of DNA synthesis by cannabinoids. Cancer Res. 36: 95-100 (1976).
    • (1976) Cancer Res , vol.36 , pp. 95-100
    • Carchman, R.A.1    Harris, L.S.2    Munson, A.E.3
  • 7
    • 0016594766 scopus 로고
    • Teratologic evaluation of Δ9-tetrahydrocannabinol in mice, including a review of the literature
    • Fleischmann, R.W., Hayden, D.W., Rosenkrantz, H., and Braude, M.C.: Teratologic evaluation of Δ9-tetrahydrocannabinol in mice, including a review of the literature. Teratology 12: 47-50 (1975).
    • (1975) Teratology , vol.12 , pp. 47-50
    • Fleischmann, R.W.1    Hayden, D.W.2    Rosenkrantz, H.3    Braude, M.C.4
  • 8
    • 0014525828 scopus 로고
    • Chromosome aberrations in cultured cells deprived of a single amino acid
    • Freed, J.J. and Schatz, S.A.: Chromosome aberrations in cultured cells deprived of a single amino acid. Expl Cell Res. 55: 393-409 (1969).
    • (1969) Expl Cell Res , vol.55 , pp. 393-409
    • Freed, J.J.1    Schatz, S.A.2
  • 9
    • 0015410809 scopus 로고
    • Liver microsomal metabolism of aflatoxin B, to a reactive derivative toxic to Salmonella typhimurium TA 1530
    • Gardner, R.C., Miller, E.C., and Miller, J.A.: Liver microsomal metabolism of aflatoxin B, to a reactive derivative toxic to Salmonella typhimurium TA 1530. Cancer Res. 32: 2058-2066 (1972).
    • (1972) Cancer Res , vol.32 , pp. 2058-2066
    • Gardner, R.C.1    Miller, E.C.2    Miller, J.A.3
  • 10
    • 0015212079 scopus 로고
    • Formation of a factor lethal for S. Thyphimurium TA 1530 and TA 1531 on incubation of aflatoxin B, with rat liver microsomes
    • Garner, J.V. and Hanson, R.S.: Formation of a factor lethal for S. thyphimurium TA 1530 and TA 1531 on incubation of aflatoxin B, with rat liver microsomes. Biochem. biophys. Res. Commun. 45: 774-779 (1971).
    • (1971) Biochem. Biophys. Res. Commun , vol.45 , pp. 774-779
    • Garner, J.V.1    Hanson, R.S.2
  • 12
    • 0017161264 scopus 로고
    • A study of teratological effects of intravenous, subcutaneous, and intragastric admin-istration of Δ9-tetrahydrocannabinol in mice
    • Joneja, M.G.: A study of teratological effects of intravenous, subcutaneous, and intragastric admin-istration of Δ9-tetrahydrocannabinol in mice. Toxic, appl. Pharmac. 36: 151-162 (1976).
    • (1976) Toxic, Appl. Pharmac , vol.36 , pp. 151-162
    • Joneja, M.G.1
  • 13
    • 0016169613 scopus 로고
    • Induction of sister chromatid exchanges by chemical mutagens and its possible relevance to DNA repair
    • Kato, H.: Induction of sister chromatid exchanges by chemical mutagens and its possible relevance to DNA repair. Cell Res. 85: 239-247 (1974).
    • (1974) Cell Res , vol.85 , pp. 239-247
    • Kato, H.1
  • 14
    • 0016272945 scopus 로고
    • Giemsa technique for the detection of sister chromatid exchanges
    • Korenberg, J.R. and Freedlender, E.F.: Giemsa technique for the detection of sister chromatid exchanges. Chromosoma 48: 355-360 (1974).
    • (1974) Chromosoma , vol.48 , pp. 355-360
    • Korenberg, J.R.1    Freedlender, E.F.2
  • 15
    • 0015824058 scopus 로고
    • Microfluorometric detection of deoxy-ribonucleic acid replication in human metaphase chromosomes
    • Latt, S.A.: Microfluorometric detection of deoxy-ribonucleic acid replication in human metaphase chromosomes. Proc. natn. Acad. Sci. USA 70: 3395-3399 (1973).
    • (1973) Proc. Natn. Acad. Sci. USA , vol.70 , pp. 3395-3399
    • Latt, S.A.1
  • 16
    • 0016301035 scopus 로고
    • Sister chromatid exchanges, indices of human chromosome damage and repair. Detection by fluorescence and induction by mitomycin C
    • Latt, S.A.: Sister chromatid exchanges, indices of human chromosome damage and repair. Detection by fluorescence and induction by mitomycin C. Proc. natn. Acad. Sci. USA 71: 3162-3166 (1974).
    • (1974) Proc. Natn. Acad. Sci. USA , vol.71 , pp. 3162-3166
    • Latt, S.A.1
  • 17
    • 0016803128 scopus 로고
    • DNA damage, DNA repair and chromosome aberrations of Xeroderma pigmentosum cells and controls following exposure to nitrosation products of methylguanidine
    • Lo, L.W. and Stich, H.F.: DNA damage, DNA repair and chromosome aberrations of Xeroderma pigmentosum cells and controls following exposure to nitrosation products of methylguanidine. Mutat. Res. 30: 397-406 (1975).
    • (1975) Mutat. Res , vol.30 , pp. 397-406
    • Lo, L.W.1    Stich, H.F.2
  • 18
    • 0016751595 scopus 로고
    • Δ9-tetrahydrocannabinol-induced changes in prenatal growth and development of mice
    • Mantilla-Plata, B., Clewe, G.L., and Harbison, R.D.: Δ9-tetrahydrocannabinol-induced changes in prenatal growth and development of mice. Toxic, appl. Pharmac. 33: 333-340 (1975).
    • (1975) Toxic, Appl. Pharmac , vol.33 , pp. 333-340
    • Mantilla-Plata, B.1    Clewe, G.L.2    Harbison, R.D.3
  • 19
    • 0345340179 scopus 로고
    • Academic Press, New York
    • Mechoulam, R.: Marijuana (Academic Press, New York 1973).
    • (1973) Marijuana
    • Mechoulam, R.1
  • 20
    • 0001406666 scopus 로고
    • Detection of carcinogens as mutagens in the Salmonella I mictosome test. Assay of 300 chemicals
    • McCann, S., Choi, E., Yamasaki, E., and Ames, B.N.: Detection of carcinogens as mutagens in the Salmonella I mictosome test. Assay of 300 chemicals. Proc. natn. Acad. Sci. USA 72: 5135-5139 (1975).
    • (1975) Proc. Natn. Acad. Sci. USA , vol.72 , pp. 5135-5139
    • McCann, S.1    Choi, E.2    Yamasaki, E.3    Ames, B.N.4
  • 21
    • 0017160179 scopus 로고
    • Action of Δ9-tetrahydrocannabinol on cell division and macromolecular synthesis in division-synchronized protozoa
    • McClean, D.K. and Zimmerman, A.M.: Action of Δ9-tetrahydrocannabinol on cell division and macromolecular synthesis in division-synchronized protozoa. Pharmacology 14: 307-321 (1976).
    • (1976) Pharmacology , vol.14 , pp. 307-321
    • McClean, D.K.1    Zimmerman, A.M.2
  • 24
    • 0016233630 scopus 로고
    • Cytogenetic studies on human subjects receiving marihuana and Δ9-tetrahydrocannabinol
    • Nichols, W.W., Miller, R.C., Henleen, W., Brandt, C., Hollister, L., and Ranter, S.: Cytogenetic studies on human subjects receiving marihuana and Δ9-tetrahydrocannabinol. Mutat. Res. 26: 413-417 (1974).
    • (1974) Mutat. Res , vol.26 , pp. 413-417
    • Nichols, W.W.1    Miller, R.C.2    Henleen, W.3    Brandt, C.4    Hollister, L.5    Ranter, S.6
  • 26
    • 0016416351 scopus 로고
    • Pharmacology of marihuana
    • Paton, W.D.M.: Pharmacology of marihuana. A. Rev. Pharmac. 15: 191-220 (1975).
    • (1975) A. Rev. Pharmac , vol.15 , pp. 191-220
    • Paton, W.D.M.1
  • 27
    • 0016851023 scopus 로고
    • Cytological detection-carcinogen exposure by sister chromatid exchange
    • Perry, P. and Evans, H.J.: Cytological detection-carcinogen exposure by sister chromatid exchange. Nature, Lond. 258: 121-125 (1975).
    • (1975) Nature, Lond , vol.258 , pp. 121-125
    • Perry, P.1    Evans, H.J.2
  • 28
    • 0016328318 scopus 로고
    • New giemsa method for the differential staining of sister chromatids
    • Perry, P. and Wolff, S.: New giemsa method for the differential staining of sister chromatids. Nature, Lond. 251: 156-158 (1974).
    • (1974) Nature, Lond , vol.251 , pp. 156-158
    • Perry, P.1    Wolff, S.2
  • 29
    • 0016757282 scopus 로고
    • DNA repair synthesis of cultured human cells as a rapid bioassay for chemical carcinogens
    • San, R.H.C. and Stich, H.F.: DNA repair synthesis of cultured human cells as a rapid bioassay for chemical carcinogens. Int. J. Cancer 16: 284-291 (1975).
    • (1975) Int. J. Cancer , vol.16 , pp. 284-291
    • San, R.H.C.1    Stich, H.F.2
  • 32
    • 0016739518 scopus 로고
    • The response of Xeroderma pigmentosum cells and controls to the activated mycotoxins, aflatoxins and sterigmato-cystin
    • Stich, H.F. and Laishes, B.A.: The response of Xeroderma pigmentosum cells and controls to the activated mycotoxins, aflatoxins and sterigmato-cystin. Int. J. Cancer 16: 266-274 (1975).
    • (1975) Int. J. Cancer , vol.16 , pp. 266-274
    • Stich, H.F.1    Laishes, B.A.2
  • 33
    • 0014867313 scopus 로고
    • DNA repair and chromatid anamolies in mammalian cells exposed to 4-nitroquinoline-l-oxide
    • Stich, H.F. and San, R.H.C.: DNA repair and chromatid anamolies in mammalian cells exposed to 4-nitroquinoline-l-oxide. Mutat. Res. 10: 389-404 (1970).
    • (1970) Mutat. Res , vol.10 , pp. 389-404
    • Stich, H.F.1    San, R.H.C.2
  • 34
    • 0000046517 scopus 로고
    • DNA repair synthesis in Xeroderma pigmentosum cells exposed to the oncogenic 4-nitroquinoline-l-oxide
    • Stich, H.F. and San, R.H.C.: DNA repair synthesis in Xeroderma pigmentosum cells exposed to the oncogenic 4-nitroquinoline-l-oxide. Mutat. Res. 13: 279-282 (1971).
    • (1971) Mutat. Res , vol.13 , pp. 279-282
    • Stich, H.F.1    San, R.H.C.2
  • 35
    • 0015535313 scopus 로고
    • DNA repair synthesis and survival of repair deficient human cells exposed to the K-region epoxide of benz(A)anthra-cene
    • Stich, H.F. and San, R.H.C.: DNA repair synthesis and survival of repair deficient human cells exposed to the K-region epoxide of benz(a)anthra-cene. Proc. Soc. exp. Biol. Med. 142: 155-158 (1973).
    • (1973) Proc. Soc. Exp. Biol. Med , vol.142 , pp. 155-158
    • Stich, H.F.1    San, R.H.C.2
  • 36
    • 0015211090 scopus 로고
    • DNA repair synthesis in mammalian cells exposed to a series of oncogenic and non-oncogenic derivatives of 4-nitroquinoline-l-oxide
    • Stich, H.F., San, R.H.C., and Kawazoe, Y.: DNA repair synthesis in mammalian cells exposed to a series of oncogenic and non-oncogenic derivatives of 4-nitroquinoline-l-oxide. Nature, Lond. 229: 416-419 (1971).
    • (1971) Nature, Lond , vol.229 , pp. 416-419
    • Stich, H.F.1    San, R.H.C.2    Kawazoe, Y.3
  • 37
    • 0015541911 scopus 로고
    • Increased susceptibility of Xeroderma pigmentosum cells to chemical carcinogens and mutagens
    • Stich, H.F., San, R.H.C., and Kawazoe, Y.: Increased susceptibility of Xeroderma pigmentosum cells to chemical carcinogens and mutagens. Mutat. Res. 17: 127-137 (1972).
    • (1972) Mutat. Res , vol.17 , pp. 127-137
    • Stich, H.F.1    San, R.H.C.2    Kawazoe, Y.3
  • 38
    • 0015611988 scopus 로고
    • Chromosome aberrations in Xeroderma pigmentosum cells exposed to the carcinogens, 4-nitroquinoline-l-oxide and N-methyl-N’-nitro-nitrosoguanidine
    • Stich, H.F., Stich, W., and San, R.H.C.: Chromosome aberrations in Xeroderma pigmentosum cells exposed to the carcinogens, 4-nitroquinoline-l-oxide and N-methyl-N’-nitro-nitrosoguanidine. Proc. Soc. exp. Biol. Med. 142: 1141-1144 (1973).
    • (1973) Proc. Soc. Exp. Biol. Med , vol.142 , pp. 1141-1144
    • Stich, H.F.1    Stich, W.2    San, R.H.C.3
  • 39
    • 0015611988 scopus 로고
    • Elevated frequency of chromosome aberrations in repair-deficient human cells exposed to the carcinogen and mutagen 4-nitroquinoline-l-oxide
    • Stich, H.F., Stich, W., and San, R.H.C.: Elevated frequency of chromosome aberrations in repair-deficient human cells exposed to the carcinogen and mutagen 4-nitroquinoline-l-oxide. Proc. Soc. exp. Biol. Med. 142: 1141-1144 (1973).
    • (1973) Proc. Soc. Exp. Biol. Med , vol.142 , pp. 1141-1144
    • Stich, H.F.1    Stich, W.2    San, R.H.C.3
  • 40
    • 3743049688 scopus 로고
    • The use of DNA repair in the identification of carcinogens, precarcinogens and target tissue
    • Scholefield, University of Toronto Press, Toronto
    • Stich, H.F., Kieser, D., Laishes, B.A., and San, R.H.C.: The use of DNA repair in the identification of carcinogens, precarcinogens and target tissue; in Scholefield, Proceedings of the Tenth Canadian Cancer Conference, vol. 10, pp. 125-170 (University of Toronto Press, Toronto 1973).
    • (1973) Proceedings of the Tenth Canadian Cancer Conference , vol.10 , pp. 125-170
    • Stich, H.F.1    Kieser, D.2    Laishes, B.A.3    San, R.H.C.4
  • 41
    • 0016719814 scopus 로고
    • Failure to detect mutagenic effects of A9-tetrahydrocannabinol in in vitro and in vivo studies with mice
    • Stoeckel, M., Weber, £., Connor, T., and Legator, M.S.: Failure to detect mutagenic effects of A9-tetrahydrocannabinol in in vitro and in vivo studies with mice. Mutat. Res. 31: 313-314 (1975).
    • (1975) Mutat. Res , vol.31 , pp. 313-314
    • Stoeckel, M.1    Weber, £.2    Connor, T.3    Legator, M.S.4
  • 43
    • 0016641016 scopus 로고
    • Reduced DNA repair capacity and increased cytotoxicity following split doses of the mutagen 4-nitroquinoline-l-oxide in cultured human cells
    • Warren, P.M. and Stich, H.F.: Reduced DNA repair capacity and increased cytotoxicity following split doses of the mutagen 4-nitroquinoline-l-oxide in cultured human cells. Mutat. Res. 28: 285-293 (1975).
    • (1975) Mutat. Res , vol.28 , pp. 285-293
    • Warren, P.M.1    Stich, H.F.2
  • 44
    • 0016286057 scopus 로고
    • Differential giemsa staining of sister chromatids and the study of sister chromatid exchanges without autoradiography
    • Wolff, S. and Perry, P.: Differential giemsa staining of sister chromatids and the study of sister chromatid exchanges without autoradiography. Chromosoma 48: 341-353 (1974).
    • (1974) Chromosoma , vol.48 , pp. 341-353
    • Wolff, S.1    Perry, P.2
  • 45
    • 84908720254 scopus 로고
    • Action of narcotic and hallucinogenic agents on the cell cycle
    • Zimmerman, Academic Press, New York
    • Zimmerman, A.M. and McClean, D.K.: Action of narcotic and hallucinogenic agents on the cell cycle; in Zimmerman, Padilla and Cameron, Drugs and the cell cycle, pp. 67-94 (Academic Press, New York 1973).
    • (1973) Padilla and Cameron, Drugs and the Cell Cycle , pp. 67-94
    • Zimmerman, A.M.1    McClean, D.K.2


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