Relation between morphine pharmacokinetics and analgesia

Journal of Pharmacokinetics and Biopharmaceutics

Volumn 6, Issue 1, 1978, Pages 41-53

  Dahlström, Bengt E ^a   Paalzow, Lennart K ^a,b   Segre, Giorgio ^c   Ågren, Allan J ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b Centrallaboratoriet ^*  (Sweden)

^c UNIVERSITY OF SIENA   (Italy)

Author keywords

morphine analgesic activity; morphine pharmacokinetics; multicompartmental behavior of morphine; relationships between morphine pharmacokinetics and analgesic effect

Indexed keywords

MORPHINE;

ANALGESIA; COMPARTMENT MODEL; COMPUTER ANALYSIS; COMPUTER MODEL; NONBIOLOGICAL MODEL; PHARMACOKINETICS;

ANALGESICS, OPIOID; ANIMAL; KINETICS; MALE; MORPHINE; RATS;

EID: 0018178767     PISSN: 0090466X     EISSN: 15738744     Source Type: Journal    
DOI: 10.1007/BF01066062     Document Type: Article

References (22)

1. Multicompartment pharmacokinetic models and pharmacologic effects
2. Relations between drug concentration and response
3. Kinetics of interaction between drugs and biological system
4. Pharmacokinetics of morphine in plasma and discrete areas of the rat brain
5. The effects of caffeine and theophylline on nociceptive stimulation in the rat
6. Pentazocine analgesia and regional rat brain catecholamines
7. Observations on the neuropharmacology of morphine and morphinelike analgesia
8. Analgesia produced by clonidine in mice and rats
9. The routine fitting of kinetic data to models: A mathematical formalism for digital computers
10. A User's Manual for NONLIN
11. Drug-absorption analysis from pharmacological data. I. Method and confirmation exemplified for the mydriatic drug Tropicamide
12. Theoretical and computational basis for drug bioavailability determinations using pharmacological data. I. General considerations and procedures
13. Some formal approaches to the analysis of kinetic data in terms of linear compartmental systems
14. Kinetics of pharmacologic response. I. Proposed relationships between response and drug concentration in the intact animal and man
15. N-Demethylation of morphine in rat brain is localised in sites with high opiate receptor content
16. Analgesics and their antagonists: Some steric and chemical considerations
17. Drug levels in the target tissue and effect
18. The formulation and testing of models