Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

Diabetologia

Volumn 14, Issue 3, 1978, Pages 141-148

  Coleman, D L ^a  

^a JACKSON LABORATORY   (United States)

Author keywords

Diabetes; genetics; hyperinsulinaemia; hyperphagia; mice; obesity

Indexed keywords

ANIMAL EXPERIMENT; CELL; DIABETES MELLITUS; ENDOCRINE SYSTEM; HEREDITY; HISTOLOGY; HYPERGLYCEMIA; HYPERINSULINEMIA; INHERITANCE; MOUSE; MUTANT; OBESITY;

ANIMAL; BODY WEIGHT; CHROMOSOMES; DIABETES MELLITUS, EXPERIMENTAL; GENES; MICE; MICE, INBRED STRAINS; MICE, OBESE; MUTATION; OBESITY IN DIABETES; RATS; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0018139377     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/BF00429772     Document Type: Review

References (35)

1. Adipose tissue: contributions of nature and nurture to the obesity of an obese mutant mouse (ob/ob)
2. The hormonal and metabolic basis of experimental obesity
3. Genetically transmitted obesity in rodents
4. Abnormalities in hepatic enzyme activites during development of diabetes in db mice
5. Studies in the diabetic mutant mouse: IV. DBM, a modified diabetic mutant produced by outcrossing the original strain
6. Effects of parabiosis of obese with diabetes and normal mice
7. Studies with the mutation, diabetes, in the mouse
8. Effects of parabiosis of normal with genetically diabetic mice
9. The influence of genetic background on the expression of the obese (ob) gene in the mouse
10. Hyperinsulinemia in preweaning diabetes (db) mice
11. Influence of genetic background on the expression of mutations at the diabetes locus in the mouse. II. Studies on background modifiers
12. Development of obesity in diabetic mice pair-fed with lean siblings
13. Feeding and drinking in suckling rats
14. Adipose, a new inherited obesity of the mouse
15. Further studies on the amelioration of the characteristics of New Zealand obese (NZO) mice following transplantation of islets of Langerhans
16. Food intake in hypothalamic obesity
17. Insulin resistance in genetically obese hyperglycemic mice
18. Function of the pancreatic ß-cell during the development of hyperglycemia in mice homozygous for the mutations diabetes (db) and misty (m)
19. Laboratory animals exhibiting obesity and diabetes syndromes
20. Differences in the development of the obese hyperglycemie syndrome in ob/ob and NZO mice
21. The influence of genetic background on expression of mutations at the diabetes locus in the mouse. I. C57BL/KsJ and C57BL/6J strains
22. Diabetes, a new mutation in the mouse
23. Obese, a new mutation in the mouse
24. Cellularity of adipose depots in six strains of genetically obese mice
25. Enlargement of epididymal adipocytes in relation to hyperinsulinemia in obese mice (ob/ob)
26. Insulin receptor interaction in the obese-hyperglycemic mouse. A model of insulin resistance
27. Insulin receptor defect in insulin resistance. Studies in the obese-hyperglycemic mouse
28. In vivo studies on lipogenesis in obese hyperglycemie (ob/ob) mice: possible role of hyperinsulinemia
29. Hepatic glycolytic and gluconeogenic enzymes of the obese hyperglycemic mouse
30. Studies of hereditary obese mice (ob/ob) after implantation of pancreatic islets in millipore filter capsules
31. Efficiency of energy utilization by the Zucker hereditary obese rat “fatty”