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Volumn 19, Issue 48, 1978, Pages 4763-4766

Model studies on Narcissus alkaloids. Synthetic methodology for the synthesis of lycoricidine analogues.

Author keywords

[No Author keywords available]

Indexed keywords

DRUG ANALYSIS; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; LYCORICIDINE DERIVATIVE; NARCISSUS ALKALOID; NUCLEAR MAGNETIC RESONANCE; THEORETICAL STUDY;

EID: 0018120324     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(01)85725-7     Document Type: Article
Times cited : (59)

References (18)
  • 2
    • 0014199791 scopus 로고
    • Narciclasine: an Antimitotic Substance from Narcissus Bulbs
    • (1967) Nature , vol.213 , pp. 595
    • Cerioffi1
  • 5
    • 84918974536 scopus 로고    scopus 로고
    • A Sage syringe drive was utilized with settings such that a 20–25 sec interval between drops was obtained.
  • 7
    • 84918974535 scopus 로고    scopus 로고
    • This reagent was prepared by simply mixing equimolar amounts of tetra-N-propyl ammonium hydroxide (10% in water) and aqueous periodic acid. The resulting thick precipitate was filtered, dried, and recrystallized from ethanol to afford needles, mp 180–182°, in 91% yield.
  • 8
    • 84918974534 scopus 로고    scopus 로고
    • Satisfactory spectral data were obtained on chromatographically homogeneous material for all new compounds reported herein. Full experimental detail will be given in our full paper.
  • 9
    • 0342294561 scopus 로고
    • For a previous example of Diels-Alder reactivity of acyl nitroso compounds note
    • (1972) J.C.S. Chem. Comm. , pp. 704
    • Kirby1
  • 17
    • 84918974531 scopus 로고    scopus 로고
    • Triacetates 6a and 14 are readily distinguished by their NMR spectra. Additionally, the observed relative RF's of 6a and 14 (0.58 vrs. 0.33 in PhH-dioxane-HOAC 20:10:1) are in accord with the expectation that the isomer in which all heteroatom substituents are on the same molecular face should be more polar.
  • 18
    • 84918974530 scopus 로고    scopus 로고
    • This paper is dedicated to Professor E.J. Corey on the occasion of his 50th birthday.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.