The effects of liver disease and aging on the disposition of diazepam, chlordiazepoxide, oxazepam and lorazepam in man

Acta Psychiatrica Scandinavica

Volumn 58, Issue 274 S, 1978, Pages 56-74

  WILKINSON, G R ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

aging; Benzodiazepines; chlordiazepoxide; diazepam; disposition; liver disease; lorazepam; oxazepam; pharmacokinetics

Indexed keywords

BETA GLUCURONIDASE; CHLORDIAZEPOXIDE; DIAZEPAM; LORAZEPAM; OXAZEPAM; ANTI ANXIETY AGENTS, BENZODIAZEPINE; ANXIOLYTIC AGENT;

AGE; DRUG BLOOD LEVEL; DRUG COMPARISON; DRUG DISPOSITION; DRUG HALF LIFE; DRUG MONITORING; DRUG RESPONSE; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; LIVER; LIVER CIRRHOSIS; LIVER DISEASE; MAJOR CLINICAL STUDY; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; OXYGEN CONSUMPTION; PHARMACODYNAMICS; PHARMACOKINETICS; PLASMA CLEARANCE; ADULT; AGED; AGING; ALCOHOL LIVER CIRRHOSIS; ARTICLE; FEMALE; HALF LIFE TIME; HUMAN; MALE; METABOLISM; VIRUS HEPATITIS;

ADMINISTRATION, ORAL; ADULT; AGED; AGING; ANTI-ANXIETY AGENTS, BENZODIAZEPINE; CHLORDIAZEPOXIDE; DIAZEPAM; FEMALE; HALF-LIFE; HEPATITIS, VIRAL, HUMAN; HUMAN; INJECTIONS, INTRAVENOUS; LIVER CIRRHOSIS, ALCOHOLIC; LIVER DISEASES; LORAZEPAM; MALE; MIDDLE AGE; OXAZEPAM;

EID: 0018114494     PISSN: 0001690X     EISSN: 16000447     Source Type: Journal    
DOI: 10.1111/j.1600-0447.1978.tb02388.x     Document Type: Article

References (38)

1. Influence of acute and chronic nicotine administration on EEG reactivity to drugs in rabbits. 2. Psychoactive agents
2. Hepatic bilirubin UDP‐glucuronyl transferase activity in liver disease and Gilbert's syndrome
3. Clinical depression of the central nervous system due to diazepam and chlordiazepoxide in relation to cigarette smoking and age
4. Increased sensitivity to nitrazepam in old age
5. Relationship between the duration of anticonvulsant activity of chlordiazepoxide and systemic levels of the parent compound and its major metabolites in mice
6. Correlation between the duration of the anticonvulsant activity of diazepam and its physiological disposition in mice
7. Chlordia‐zepoxide metabolism as related to reduction in aggressive behavior of cynomolgus primates
8. Pharmacokinetics in the elderly
9. Blood level distribution patterns of diazepam and its major metabolite in man
10. Radioimmunoassy of chlordiazepoxide in plasma
11. N‐desmethyl‐diazepam: A metabolite of chlordiazepoxide in man
12. 14C‐lorazepam
13. Toxicity of high dose flurazepam in the elderly
14. The effects of age and liver disease on the disposition and elimination of diazepam in man
15. Disposition of lorazepam in humans. Determination of the drug by electron capture gas chromatography
16. 14‐labelled chlordiazepoxide in man, in the dog and in the rat
17. The effects of aging and liver disease on the disposition of lorazepam in man
18. Persistence of antibiotics in blood of patients with acute renal failure. II. Chloramphenicol and its metabolic products in the blood of patients with severe renal disease or hepatic cirrhosis
19. Species differences in diazepam metabolism and anticonvulsant effect
20. Pharmacological and clinical studies on Valium, a new psychotherapeutic agent of the benzodiazepine class
21. Pharmacology of the metabolites of chlordiazepoxide and diazepam
22. The relationship between diazepam dose, plasma level, age and central nervous system depression in adults
23. The effect of age and parenchymal liver disease on the disposition and elimination of chlordiazepoxide (Librium)
24. Metabolic N‐demethylation of chlordiazepoxide
25. Metabolism of diazepam in vitro
26. Metabolites of demoxepam, a chlordiazepoxide metabolite in man
27. Metabolism of diazepam in rat, dog and man
28. Urinary metabolites of lorazepam in humans and four animal species
29. Lorazepam: Glucuronide formation in the cat
30. Normal disposition of oxazepam in acute viral hepatitis and cirrhosis
31. The biotransformation of oxazepam in man, miniature swine, and rat
32. Pharmacokinetics in the aged; a review
33. Biotransformation and excretion of lorazepam in patients with chronic renal failure
34. Absorption, metabolism and excretion of oxazepam and its succinate half‐ester
35. A physiological approach to hepatic drug clearance
36. Drug disposition in liver disease
37. Effects of liver disease on drug disposition in man