Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats

Toxicology and Applied Pharmacology

Volumn 46, Issue 2, 1978, Pages 279-303

  Kociba, R J ^a   Keyes, D G ^a   Beyer, J E ^a   Carreon, R M ^a   Wade, C E ^a   Dittenber, D A ^a   Kalnins, R P ^a   Frauson, L E ^a   Park, C N ^a   Barnard, S D ^a   Hummel, R A ^a   Humiston, C G ^a  

^a Toxicology Research Laboratory Health and Environmental Research Dow Chemical ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; PORPHYRIN;

ANIMAL EXPERIMENT; BLOOD AND HEMOPOIETIC SYSTEM; CARCINOGENESIS; CARCINOGENICITY; DOSE TIME EFFECT RELATION; DRUG RESPONSE; DRUG TOXICITY; ETIOLOGY; GUSTATORY SYSTEM; HEMATOLOGY; HISTOLOGY; HISTOPATHOLOGY; INTOXICATION; LIVER; LIVER INJURY; LUNG; MORTALITY; MOUTH; NOSE; OLFACTORY SYSTEM; ORAL DRUG ADMINISTRATION; PALATE; PHARMACOKINETICS; RAT; RESPIRATORY SYSTEM; SEX DIFFERENCE; SEX DIFFERENTIATION; TONGUE; TOXICITY; URINE; VESTIBULAR SYSTEM;

AMINOLEVULINIC ACID; ANIMALS; CARCINOGENS; DIET; DIOXINS; FEMALE; MALE; ORGAN SIZE; PORPHYRINS; RATS; TETRACHLORODIBENZODIOXIN; TIME FACTORS;

EID: 0018074887     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/0041-008X(78)90075-3     Document Type: Article

References (9)

1. Morphological change in monkeys consuming a diet containing five hundred parts per trillion of 2,3,7,8 tetrachlorodibenzo-p-dioxin
2. Tumor initiating ability of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Arochlor 1254 in the two-stage system of mouse skin carcinogenesis
3. Bioassay of pesticides and industrial chemicals for tumorigenicity in mice: A preliminary note
4. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCCD): Results of a 13-week oral toxicity study in rats
5. Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rhesus monkeys (Macaca mulatta) following a single oral dose
6. Chronic toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats
7. Increased incidence of neoplasms in rats exposed to low levels of 2,3,7,8-tetrachlorodibenzo-o-dioxin