Biochemical identification of the site of action of benzodiazepines in human brain by 3H-diazepam binding

Life Sciences

Volumn 22, Issue 11, 1978, Pages 985-995

  Mohler H ^a   Okada, T ^a   Heitz, Ph ^b   Ulrich, J ^b  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLFLUNITRAZEPAM; BENZODIAZEPINE; BROMAZEPAM; CHLORDIAZEPOXIDE; CLONAZEPAM; CLORAZEPATE; DIAZEPAM; DRUG RECEPTOR; FLUNITRAZEPAM; FLURAZEPAM; LORAZEPAM; MEDAZEPAM; NITRAZEPAM; OXAZEPAM; RADIOISOTOPE; RO 11 7800; RO 5 2181; TRIAZOLAM; UNCLASSIFIED DRUG;

BRAIN; BRAIN CORTEX; BRAIN HOMOGENATE; CENTRAL NERVOUS SYSTEM; CEREBELLUM; DIAZEPAM H 3; DRUG MECHANISM; ENANTIOMER; HUMAN; HUMAN CELL; IN VITRO STUDY; RO 11 7800; RO 5 2181; SPECIES DIFFERENCE; STEREOSPECIFICITY;

AGED; ANTI-ANXIETY AGENTS, BENZODIAZEPINE; BRAIN; BRAIN MAPPING; CEREBELLUM; CEREBRAL CORTEX; DIAZEPAM; FEMALE; HUMAN; KINETICS; LIGANDS; MALE; MIDDLE AGE; RECEPTORS, DRUG; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

EID: 0017874347     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/0024-3205(78)90364-8     Document Type: Article

References (15)

1. Properties of 3H-diazepam binding to benzodiazepine receptors in rat cerebral cortex
2. Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding.