SIXTH GADDUM MEMORIAL LECTURE NATIONAL INSTITUTE FOR MEDICAL RESEARCH, MILL HILL, JANUARY 1977: PRESYNAPTIC RECEPTORS AND THEIR ROLE IN THE REGULATION OF TRANSMITTER RELEASE

British Journal of Pharmacology

Volumn 60, Issue 4, 1977, Pages 481-497

  LANGER, S Z ^a  

^a WELLCOME RESEARCH LABORATORIES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; BUCLADESINE; CLONIDINE; COCAINE; H 110/38; ISOPRENALINE; METIROSINE; MUSCARINIC RECEPTOR; NEUROTRANSMITTER; OPIATE RECEPTOR; PAPAVERINE; PHENOXYBENZAMINE; PHENTOLAMINE; PRESYNAPTIC RECEPTOR; PROPRANOLOL; RADIOISOTOPE; SALBUTAMOL; SEROTONIN RECEPTOR; TERBUTALINE; THEOPHYLLINE; TYRAMINE; UNCLASSIFIED DRUG; YOHIMBINE; DRUG RECEPTOR; NORADRENALIN;

AUTONOMIC NERVOUS SYSTEM; CAT; CENTRAL NERVOUS SYSTEM; DOPAMINE H 3; NORADRENALIN H 3; THEORETICAL STUDY; ANIMAL; ELECTROSTIMULATION; IN VITRO STUDY; METABOLISM; NERVE ENDING; PHYSIOLOGY; REVIEW;

ANIMAL; CENTRAL NERVOUS SYSTEM; ELECTRIC STIMULATION; IN VITRO; NERVE ENDINGS; NEUROTRANSMITTERS; NOREPINEPHRINE; RECEPTORS, ADRENERGIC, ALPHA; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, DRUG;

EID: 0017750402     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1977.tb07526.x     Document Type: Article

References (120)

1. Possible role of a β‐adrenoceptor in the regulation of noradrenaline release by nerve stimulation through a positive feed‐back mechanism
2. The distribution of substance P and 5‐hydroxytryptamine in the central nervous system of the dog
3. Different alpha‐adrenoceptors in the central nervous system mediating biochemical and functional effects of clonidine and receptor blocking agents
4. Effects of clonidine and guanethidine on peripheral sympathetic nerve function in the pithed rat
5. Adrenergic neuron blocking properties of (+)‐propranolol and (+)‐propranolol
6. Pharmacological experiments on the release of the sympathetic transmitter
7. Evidence that blockade of adrenergic receptors causes overflow of norepinephrine in cat's colon after nerve stimulation
8. The output of sympathetic transmitter from the spleen of the cat
9. Receptor‐mediated control of dopamine metabolism
10. Choline esters in tissue extracts
11. Release of norepinephrine and dopamine‐β‐hydroxylase by nerve stimulation. I. Role of neuronal and extraneuronal uptake and of alpha presynaptic receptors
12. Release of norepinephrine and dopamine‐β‐hydroxylase by nerve stimulation. IV. An evaluation of a role for cyclic adenosine monophosphate
13. Nerve‐stimulation mediated overflow of norepinephrine and dopamine‐β‐hydroxylase. III. Effects of norepinephrine depletion on the alpha presynaptic regulation of release
14. Prejunctional inhibition of adrenergic nervous vasomotor control due to β‐receptor blockade. Proceeds. Symposium on
15. Facilitation of the release of noradrenaline and dopamine‐β‐hydroxylase at low stimulation frequencies by α‐blocking agents
16. Cyclic AMP and alpha‐receptor mediated modulation of noradrenaline release from rat brain slices
17. 3H‐noradrenaline released by nerve stimulation in the perfused cat's spleen
18. Negative feed‐back regulation of noradrenaline release by nerve stimulation in the perfused cat's spleen: differences in potency of phenoxybenzamine in blocking the pre‐ and postsynaptic adrenergic receptors
19. Evidence against a physiological role of prostaglandins in the regulation of noradrenaline release in the cat spleen
20. 3H‐norepinephrine released from the perfused cat spleen: differences observed during and after the period of stimulation
21. Inhibition of the extraneuronal accumulation and metabolism of norepinephrine by adrenergic blocking agents
22. Influence of reserpine‐induced depletion of noradrenaline on the negative feed‐back mechanism for transmitter release during nerve stimulation
23. 3H‐noradrenaline release elicited by nerve stimulation in the isolated cat's nictitating membrane
24. Role of the α‐adrenoceptor in regulating noradrenaline overflow by nerve stimulation
25. Protection by phentolamine against the effects of phenoxybenzamine on transmitter release elicited by nerve stimulation in the perfused cat heart
26. 3H‐noradrenaline from field stimulated rat iris
27. 3H‐monoamines from field stimulated rat brain slices
28. 3H‐Noradrenaline release and mechanical response in the field stimulated mouse vas deferens
29. The chemical transmitter of synapses in a sympathetic ganglion
30. 3H‐noradrenaline release induced by potassium from normal and atrophied rat submaxillary glands
31. Estimation of substances liberated by adrenergic nerves
32. Antagonism between lysergic acid diethylamide and 5‐hydroxytryptamine
33. Properties of the substance liberated by adrenergic nerves in a rabbit's ear
34. The estimation of adrenaline and allied substances in blood
35. The effect of desmethylimipramine upon the overflow of sympathetic transmitter from the cat's spleen
36. Relation between the rate of stimulation and the quantity of noradrenaline liberated from sympathetic nerve endings in the isolated perfused spleen of the cat
37. Clonidine‐induced inhibition of sympathetic nerve activity: no indication for a central presynaptic or an indirect sympathomimetic mode of action
38. Some further aspects on the release of the adrenergic transmitter
39. 2 on sympathetic neurotransmission in the cat spleen
40. Further evidence that prostaglandins inhibit the release of noradrenaline from adrenergic nerve terminals by restriction of availability of calcium
41. Effects of adenosine on adrenergic neurotransmission: prejunctional inhibition and postjunctional enhancement
42. Presynaptic α‐ and β‐adrenoceptor mediated control of noradrenaline release in human oviduct
43. Effects of drugs and sympathetic denervation on noradrenaline uptake and binding in animal tissues
44. 3‐noradrenaline release following postganglionic sympathetic nerve stimulation in the isolated cat spleen
45. The effect of propranolol on sympathetic nerve stimulation in isolated vasa deferentia
46. Effect of morphine on adrenergic transmission in the mouse vas** deferens. Assessment of agonist and antagonist potencies of narcotic analgesics
47. Evidence that angiotensin enhances transmitter release during sympathetic nerve stimulation
48. The inhibition of noradrenaline uptake by drugs
49. Effect of phenoxybenzamine on the uptake and metabolism of noradrenaline in the rat heart and vas deferens
50. Comparison of the effects of neuroleptic drugs on pre‐ and postsynaptic dopaminergic mechanisms in the rat striatum
51. Effect of cocaine, phenoxybenzamine and phentolamine on the catecholamine output from spleen and adrenal medulla
52. Inhibition by sympathomimetic amines of the release of norepinephrine evoked by nerve stimulation in the cat spleen
53. Centrally induced reduction in sympathetic tone—a postsynaptic α‐adrenoceptor stimulating action of imidazolines
54. 3H‐noradrenaline released by electrical stimulation from the isolated nictitating membrane of the cat and from the vas deferens of the rat
55. The regulation of transmitter release elicited by nerve stimulation through a presynaptic feedback mechanism
56. Selective metabolic pathways for noradrenaline in the peripheral and in the central nervous system
57. Presynaptic regulation of catecholamine release
58. Denervation supersensitivity
59. The role of α‐ and β‐presynaptic receptors in the regulation of noradrenaline release elicited by nerve stimulation
60. Physiological significance of the alpha‐adrenoceptor mediated negative feed‐back mechanism that regulates noradrenaline release during nerve stimulation
61. Time course of the development of supersensitivity to various amines in the nictitating membrane of the pithed cat after denervation and decentralization
62. Subsensitivity of presynaptic α‐adrenoceptors after exposure to noradrenaline
63. Prejunctional regulatory mechanisms for noradrenaline release elicited by nerve stimulation
64. The potentiation of responses to adrenergic nerve stimulation in the presence of cocaine: its relationship to the metabolic fate of released norepinephrine
65. Presynaptic regulatory mechanisms for noradrenaline release by nerve stimulation. Proceeds. Symposium on
66. Regulation of transmitter release
67. Subsensitivity of the presynaptic alpha‐adrenoceptors after short term surgical denervation of the cat nictitating membrane
68. Pre‐ and post‐synaptic origin of the norepinephrine metabolites formed during transmitter release elicited by nerve stimulation
69. The onset of denervation supersensitivity
70. Noradrenaline release from isolated muscles of the nictitating membrane of the cat
71. Effect of acute and chronic treatment with practolol on cardiovascular responses in the pithed rat
72. A muscarinic mechanism inhibiting the release of noradrenaline from peripheral adrenergic nerve fibres by nicotinic drugs
73. Impaired vasoconstrictor nerve function in spontaneously hypertensive rats after long‐term treatment with propranolol and metoprolol
74. Nicotinic drugs and postganglionic sympathetic transmission
75. A muscarinic inhibition of the noradrenaline release evoked by postganglionic sympathetic nerve stimulation
76. Effect of presynaptic α‐adrenoceptor blockade on responses to cardiac nerve stimulation in anaesthetised dogs
77. Inhibition of the sympathetic nervous system by 5,6‐dihydroxy‐2‐dimethyl‐amino tetralin (M‐7), apomorphine and dopamine
78. 3H‐transmitter release elicited by nerve stimulation in the isolated nerve‐muscle preparation of the cat nictitating membrane
79. Effects of narcotic analgesics and their antagonists on the rabbit isolated heart and its adrenergic nerves
80. Influence of morphine and naloxone on the release of noradrenaline from rat brain cortex slices
81. 3H‐noradrenaline release from sympathetic nerves of guinea‐pig atria by a presynaptic α‐adrenoceptor mechanism
82. Evidence for a dopaminergic mechanism for modulation of adrenergic transmission in the rabbit ear artery
83. Clonidine antinociceptive activity: effects of drugs influencing central monoaminergic and cholinergic mechanisms in the rat
84. Pre‐junctional modulation of noradrenergic transmission by noradrenaline, dopamine and acetylcholine
85. Pulse‐to‐pulse modulation of noradrenaline release through a prejunctional α‐receptor auto‐inhibitory mechanism
86. Effect of clonidine on responses to cardiac nerve stimulation as a function of impulse frequency and stimulus duration in vagotomized dogs
87. Tyrosine hydroxylase: Allosteric activation induced by stimulation of central noradrenergic neurons
88. Dopamine neurons: Role of impulse flow and presynaptic receptors in the regulation of tyrosine hydroxylase
89. Effect of clonidine on cardiac acceleration in vagotomized dogs
90. Antipsychotic drugs: direct correlation between clinical potency and presynaptic action on dopamine neurons
91. Effects of theophylline and propranolol on acetylcholine induced release of adrenal medullary catecholamines
92. Serial histologic effects of rat submaxillary and sublingual salivary gland duct and blood vessel ligation
93. Interactions of angiotensin and cocaine on the output of noradrenaline from isolated rabbit hearts
94. 14C‐noradrenaline by isolated rabbit hearts
95. Alpha sympathomimetic inhibition of adrenergic and cholinergic transmission in the rabbit heart
96. Influence of extracellular noradrenaline on the stimulation‐evoked secretion of noradrenaline from sympathetic nerves: Evidence for an alpha receptor mediated feed‐back inhibition of noradrenaline release
97. Inhibition of adrenergic neurotransmission by clonidine: An action on prejunctional α‐receptors
98. Preferential blockade of presynaptic α‐adrenoceptors by yohimbine
99. Relative pre‐ and postsynaptic potencies of α‐adrenoceptor agonists in the rabbit pulmonary artery
100. Alpha‐receptor mediated modulation of transmitter release from central noradrenergic neurones
101. Comparison of the effects of clonidine of pre‐and postsynaptic adrenoceptors in the rabbit pulmonary artery
102. Influence of cocaine and phenoxybenzamine on noradrenaline uptake and release
103. Inhibition of adrenergic neurotransmission by parasympathomimetics in the rabbit ear artery
104. 2 on noradrenaline secretion from sympathetic nerves as a function of external calcium
105. Dual adrenoceptor‐mediated control of noradrenaline secretion from human vasoconstrictor nerves: Facilitation by β‐receptors and inhibition by α‐receptors
106. 2‐adrenoceptors facilitating noradrenaline secretion from human vasoconstrictor nerves
107. Additive stimulating effects of inhibitor of prostaglandin synthesis and of β‐adrenoceptor agonist on sympathetic neuroeffector function in human omental blood vessels
108. Prostaglandin‐dependent and ‐independent feedback control of noradrenaline secretion in vasoconstrictor nerves of normotensive human subjects. A preliminary report
109. Catecholamine receptor agonists. Effects on motor activity and rate of tyrosine hydroxylation in mouse brain
110. Depression of acetylcholine release from cerebral cortical slices by cholinesterase inhibition and by oxotremorine
111. Stimulation‐induced release of norepinephrine from rat superior cervical ganglia in vitro
112. An unidentified depressor substance in certain tissue extracts
113. 3H‐dopamine from rat striatal slices
114. Enhanced release of dopamine‐β‐hydroxylase and norepinephrine from sympathetic nerves by dibutyryl adenosine 3′5′‐monophosphate and theophylline
115. Regulation of norepinephrine release from cardiac sympathetic fibers in the dog by presynaptic alpha and beta receptors