On the inhibition of muscle membrane chloride conductance by aromatic carboxylic acids

Journal of General Physiology

Volumn 69, Issue 6, 1977, Pages 879-896

  Palade, P T ^a,b   Barchi, R L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DICHLOROPHENOXYACETIC ACID; BENZOIC ACID; CARBOXYLIC ACID; CHLORIDE; DRUG RECEPTOR;

2 AMINO 3,5 DICHLOROBENZOIC ACID; 2 CARBOXY 4,5 DICHLOROBENZOIC ACID; 2,3,5,6 TETRAMETHYLBENZOIC ACID; 2,4 DIMETHYLBENZOIC ACID; 2,5 DIMETHYLBENZOIC ACID; 3,4 DICHLOROBENZOIC ACID; 3,4 DIMETHYLBENZOIC ACID; 4 AMINO 3,5 DIMETHYLBENZOIC ACID; CELL MEMBRANE CONDUCTANCE; DOSE RESPONSE; DRUG COMPARISON; DRUG RESPONSE; DRUG SCREENING; IN VITRO STUDY; LIPOPHILICITY; MESITYLENECARBOXYLIC ACID; MUSCLE; MUSCLE FIBER MEMBRANE; PENTACHLOROBENZOIC ACID; RAT; STRUCTURE ACTIVITY RELATION; THEORETICAL STUDY; TRICHLOROBENZOIC ACID;

ANIMAL; CARBOXYLIC ACIDS; CELL MEMBRANE; CHLORIDES; DEPRESSION, CHEMICAL; DIAPHRAGM; ELECTROPHORESIS; ERYTHROCYTES; IN VITRO; LIPOSOMES; MALE; MEMBRANE POTENTIALS; MUSCLES; RATS; SARCOLEMMA; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0017750206     PISSN: 00221295     EISSN: 15407748     Source Type: Journal    
DOI: 10.1085/jgp.69.6.879     Document Type: Article

References (42)

1. Adrian, R. H. 1961. Internal chloride concentration and chloride efflux of frog muscle. J. Physiol. (Lond.). 156: 632.
2. Adrian, R. H., and S. H. Bryant. 1974. On the repetitive discharges in myotonic muscle fibers. J. Physiol. (Lond.). 240: 505-515.
3. Adrian, R. H., and M. W. Marshall. 1976. Action potentials reconstructed in normal and myotonic muscle fibers. J. Physiol. (Lond.). 258: 125-143.
4. Bangham, A. D., R. Flemens, A. D. Heard, and G. V. F. Seaman. 1958. An apparatus for the microelectrophoresis of small particles. Nature (Lond.). 182: 642-644.
5. Bangham, A. D., M. W. Hill, and N. G. Miller. 1974. Preparation and use of liposomes as models of biological membranes. In Methods in Membrane Biology. E. D. Korn, editor. Plenum Publishing Corp., New York.
6. Barchi, R. L. 1975. Myotonia: an evaluation of the chloride hypothesis. Arch. Neurol. 32: 175-180.
7. Barker, J. L., and H. Levitan. 1975. Mitochondrial uncoupling agents. Effects on membrane permeability of molluscan neurons. J. Membr. Biol. 25: 361-380.
8. Bretag, A. H. 1973. Mathematical modelling of the myotonic action potential. In New Developments in Electromyography and Clinical Neurophysiology. Vol. 1. J. E. Desmedt, editor. S. Karger, Basel. 464-482
9. Brown, W. E., and A. V. Hill. 1922. The oxygen dissociation curve of blood and its thermodynamic basis. Proc. R. Soc. Lond. Ser. B Biol. Sci. B94: 297-333.
10. Bryant, S. H. 1969. Cable properties of external intercostal muscle fibers from myotonic and non-myotonic goats. J. Physiol. (Lond.). 204: 539-550.
11. Bryant, S. H. 1973. The electrophysiology of myotonia with a review of congenital myotonia of goats. In New Developments in Electromyography and Clinical Neurophysiology. Vol. 1. J. E. Desmedt, editor. S. Karger, Basel. 420-450.
12. Bryant, S., and A. Morales-Aguilera. 1971. Chloride conductance in normal and myotonic muscle fibers and the action of monocarboxylic aromatic acids. J. Physiol. (Lond.). 219: 367-383.
13. D’Arrigo, J. S. 1973. Possible screening of surface charges on crayfish axons by polyvalent metal ions. J. Physiol. (Lond.). 231: 117-128.
14. D’Arrigo, J. S. 1974. Axonal surface charges: binding or screening by divalent cations governed by external pH. J. Physiol. (Lond.). 243: 757-764.
15. Edson, E. F., and D. M. Sanderson. 1964. Toxicities and myotonic activities of certain polychlorobenzoic acids. Biochem. Pharmacol. 13: 1538-1539.
16. Eisenman, G. 1962. Cation selective glass electrodes and their mode of operation. Biophys. J. 2: 259-323.
17. Eisenman, G. 1965. Proceedings of the 23rd International Congress of Physiological Sciences, Tokyo. 489-506. Exerpta Medica Foundation, Amsterdam.
18. Frankenhaeuser, J. A., and A. L. Hodgkin. 1957. The action of calcium on the electrical properties of squid axons. J. Physiol. (Lond.). 137: 218-244.
19. Fujita, T., J. Iwasa, and C. Hansch. 1964. A new substituent constant, π, derived from partition coefficients. J. Am. Chem. Soc. 86: 5175-5180.
20. Fukui, K., G. Nagata, and T. Yonezawa. 1958. Electronic structure and auxin activity of benzoic acid derivatives. J. Am. Chem. Soc. 80: 2267-2270.
21. Hammett, L. P. 1970. Physical Organic Chemistry. 2nd edition. McGraw-Hill Book Company, New York.
22. Hansch, C., and T. Fujita. 1964. P-σ-π analysis. A method for the correlation of biological activity and chemical structure. J. Am. Chem. Soc. 86: 1616-1626.
23. Hansch, C., R. M. Muir, T. Fujita, P. D. Maloney, F. Geiger, and M. Streich. 1963. The correlation of biological activity of plant growth regulators and Chloromycetin derivatives with Hammett constants and partition coefficients. J. Am. Chem. Soc. 85: 2817-2824.
24. Hansch, C., and W. R. Glave. 1971. Structure-activity relationships in membrane perturbing agents. Mol. Pharmacol. 7: 337-354.
25. Hutter, O. F., and D. Noble. 1960. The chloride conductance of frog skeletal muscle J. Physiol. (Lond.). 151: 89-102.
26. Jaffe, H. H. 1953. A reexamination of the Hammett equation. Chem. Rev. 53: 191-261.
27. Landau, W. M. 1952. The essential mechanism in myotonia. An electromyographic study. Neurology. 2: 369-388.
28. Levitan, H., and J. L. Barker. 1972a. Salicylate: a structure-activity study of its effects on membrane permeability. Science (Wash. D. C.). 176: 1423-1425.
29. Levitan, H., and J. L. Barker. 1972b. Membrane permeability: cation selectivity reversibly altered by salicylate. Science (Wash. D. C.). 178: 63-64.
30. Lipicky, R. J., S. H. Bryant, and J. H. Salmon. 1971. Cable parameters, sodium, potassium, chloride and water content, and potassium efflux in isolated intercostal muscles of normal volunteers and patients with myotonia congenita. J. Clin. Invest. 50: 2091-2103.
31. Mahler, H. R., and E. H. Cordes. 1971. Biological Chemistry. 2nd edition. Harper & Row, Publishers, Inc., New York.
32. McDaniel, D., and H. Brown. 1958. An extended table of Hammet substituent constants based on the ionization of substituted benzoic acids.7. Org. Chem. 23: 420-427.
33. McLaughlin, S. G. A., G. Szabo, and G. Eisenman. 1971. Divalent cations and the surface potential of charged phospholipid membranes. J. Gen. Physiol. 58: 667-687.
34. Moffett, R. B., and A. H. Tang. 1968. Skeletal muscle stimulants. Substituted benzoic acids. J. Med. Pharm. Chem. 11: 1020-1022.
35. Morgan, K. G., R. K. Entrikin, and S. H. Bryant. 1975. Myotonia and block of chloride conductance by iodide in avian muscle. Am. J. Physiol. 229: 1155-1158.
36. Nie, N., C. Hull, J. Jenkins, K. Steinbrenner, and O. Bent. 1975. Statistical package for the social sciences. McGraw-Hill Book Company, New York.
37. Palade, P. T., and R. L. Barchi. 1977. Characteristics of chloride conductance in muscle fibers of the rat diaphragm. J. Gen. Physiol. 69: 325-342.
38. Rudel, R., and J. Senges. 1972. Mammalian skeletal muscle: Reduced chloride conductance in drug-induced myotonia and induction of myotonia by low chloride solution. Naunyn-Schmiedeberg’s Arch. Pharmakol. 274: 337-347.
39. ++ with Myxicola giant axons and a description in terms of a simple surface charge model. J. Physiol. (Lond.). 248: 613-624.
40. Winer, N., D. M. Klachko, R. D. Baer, P. L. Langley, and T. W. Burns. 1966. Myotonic response induced by inhibitors of cholesterol biosynthesis. Science (Wash. D. C.). 153: 312-313.
41. Wright, E. N., and J. M. Diamond. 1968. Effects of pH and polyvalent cations on the selective permeability of the gallbladder epithelium to monovalent ions. Biochim. Biophys. Acta. 163: 57-74.
42. Yermishkin, L. N., Y. A. Liberman, and V. V. Smolyaninov. 1968. Permeability to ions of a membrane with narrow pores. Biofizika. 13: 205-207.