Hepatic uptake, intracellular protein binding and biliary excretion of amethopterin

Biochemical Pharmacology

Volumn 26, Issue 13, 1977, Pages 1235-1240

  Strum, Williamson B ^a   Liem, H Heng ^a  

^a SCRIPPS CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; METHOTREXATE; RADIOISOTOPE;

ACTIVE TRANSPORT; BILE; BILIARY EXCRETION; CONJUGATION; DRUG ABSORPTION; DRUG EXCRETION; DRUG METABOLISM; DRUG PROTEIN BINDING; LIVER; METHOTREXATE H 3; MICHAELIS CONSTANT; PHARMACOKINETICS; PLASMA; RAT; THEORETICAL STUDY;

ANIMAL; BILE; CHROMATOGRAPHY, ION EXCHANGE; CYTOSOL; FOLIC ACID; IN VITRO; INTESTINAL ABSORPTION; IODOACETATES; LIVER; MALE; METHOTREXATE; PERFUSION; PROTEIN BINDING; RATS; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS;

EID: 0017736255     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(77)90111-3     Document Type: Article

References (24)

1. Crystalline Dihydropteroylglutamic Acid
2. Determination of Molecular Weights of Proteins by Gel Filtration of Sephadex.
3. Formation of 10-Formylfolic Acid, a Potent Inhibitor of Dihydrofolate Reductase, in Rat Liver Slices Incubated with Folic Acid
4. A functional, active transport system for methotrexate in freshly isolated hepatocytes